About Author:
Dipak Kumar Dash
M Pharm pharmaceutics
Production officer -Akorn india pvt ltd
dipak.dipak.dash@gmail.com

INTRODUCTION
Introduction In recent years, polymeric controlled drug delivery systems have evolved as one of the most attractive areas in drug delivery research. The drug release is controlled by properties of the polymer-drug system and also by other factors like pH, enzymes etc. Despite several advantages offered by the controlled drug release, one important problem pertinent to the entire field is that all the systems so far developed give release rates that are constant or decrease with time.Increased delivery on demand will be very beneficial in situations like, delivery of insulin for patients with diabetes mellitus, antiarrythmics in case of heart disorders and nitrates in case of angina pectoris. This increased delivery on demand can be achieved by using external feed back control systems such as magnetic control. The concept of magnetically controlled drug delivery for the first time was proposed be Tyle in 1988. A system has been developed to magnetize the carriers so that these particles can be retained on the target site by the application of an external magnetic field of appropriate strength. Magnetic fields are believed to be harmless to biological systems and adaptable to any part of the body.

About Authors:
Narasimha Murthy Yedulapurapu*, Babu Rao. Chandu
Donbosco P.G. College of Pharmacy, 5th mile,
Pulladigunta, Kornepadu (V), vatticherukuru (M),
Guntur, Pin code: 522017, Andhra Pradesh.
*Murthyvedulapurapu@gmail.com

ABSTRACT:
Cefixime Trihydrate is an orally active third generation cephalosporin. It has plasma half-life of 3-4hrs; it is active against Gram+ve as well as Gram-ve bacteria. The present investigation involves the enhancement of dissolution rate of cefixime by using various solid dispersion techniques with a view to prolong the drug release in the gastrointestinal tract and consequently into the plasma. The solid dispersions were formulated by using the Croscarmelose sodium as a disintegrant. The solid dispersions were prepared by solvent evaporation, kneading, Physical mixing, Co-grinding techniques. In solvent evaporation technique, Dichloromethane is used as a solvent and in kneading technique water is used as solvent. The prepared solid dispersions were evaluated for in-vitro dissolution studies. Among the 5 formulations F5 sows the good results.

Applications are invited for the position of a Junior Research Fellow in DBT-sponsored project: "Study the role of miRNA in regulation of cell death in Parkinson's Disease".

Post: Junior Research Fellow

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Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram is an Institute of National Importance  established by an Act  of the Indian Parliament  and  under the 2 administrative control of the Department of Science and Technology, Government of India.

About Author:
Kambham Venkateswarlu
Final Year Graduate student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor-517132, Andhra Pradesh, India
k.v.reddy9441701016@gmail.com

ABSTRACT:
Electrophoresis is also called as cataphoresis. It is the motion of dispersed particles relative to a fluid under the influence of spatially uniform electric field. This electro kinetic phenomenon was observed for the first time in 1807 by Reuss (Moscow State University), who noticed that the application of a constant electric field caused clay particles dispersed in water to migrate. It is ultimately caused by the presence of a charged interface between the particle surface and the surrounding fluid. Electrophoresis is a rapid separation technique.Factors governing the migration of ions are Charge of ions, Size of the ions, Viscosity of the medium, Voltage applied, pH of buffer and ionic strength. Factors affecting electrophoresis are Molecular characteristics (size, shape), Buffer Properties, Electric Field Characteristics, Temperature.

About Author:
Kambham Venkateswarlu
1-Final Year Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chottoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
Hepatitis is a general term meaning inflammation of the liver and can be caused by a variety of different viruses such as hepatitis-A, B, C, D, and E. Since the development of jaundice is a characteristic of liver disease, a correct diagnosis can only be made by testing patient’s sera for the presence of specific anti-viral antibiotics. Transmission of HAV is typically by the faecal, oral route. Hepatitis A was formerly called infectious hepatitis, Epidemic hepatitis, Epidemic jaundice, Catarrhal jaundice, type A hepatitis, HA.

With the bricks of inveterate faith in ourselves was laid the foundation of Finition Solutions, Rising from a small Consulting company that planted its roots in the Nawabs or pearl City Hyderabad / India, Finition Solutions has grown over the years into a dynamic medium-sized business activities spanning through India, UK and USA.

About Author:
Kambham venkateswarlu
graduate student
Sri lakshmi narasimha college of pharmacy,
palluru, chittor-517132, andhra pradesh, india
k.v.reddy9441701016@gmail.com

ABSTRACT:
Nanotechnology is the technology of nanoparticles which are made of polymers of synthetic or natural origin. Nanoparticle is a collective name for nanospheres and nanocapsules of size from 10-1000nm. Nanocapsules are vesicular systems in which drug is confined to a cavity surrounded by a unique polymer membrane. Nanospheres are matrix systems in the drug are physically and uniformly dispersed. Nanotechnology is the design, characterization, production on and application of structures, devices and systems by controlling shape and size on the nanoscale. Nanotechnology in medicine is referred to as nanomedicine and involves the implementation of technologies that exist or function at the cellular and levels medical use.

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About Author:
Dr. Amit Gangwal
Pharmacy college as a Lecture,
Smriti college of pharmaceutical education, Indore
gangwal.amit@gmail.com

The pharmaceutical industries world over, are in a period of crisis due to the poor number of approved drug molecules relative to the high levels of R&D investment. The drug industry is facing major scientific and strategic challenges. Conversion of genomics knowledge into new molecules seems to be unimpressive and futile. Moreover competition from generic giants is giving tough competitions to established products. Indian companies are no exception; rather, hardly any molecule has been delivered by Indian companies since time immemorial (readers are kindly requested to correct/update me, if I am not acknowledging some discovered molecule).

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an ‘Institute of National Importance’.

The Birla Institute of Technology & Science, BITS Pilani is an all-India Institute for higher education. The primary motive of BITS is to "train young men and women able and eager to create and put into action such ideas, methods, techniques and information". The Institute is a dream come true of its founder late Mr G.D.Birla - an eminent industrialist, a participant in Indian freedom struggle and a close associate of the Father of Indian Nation late Mr. Mohandas Karamchand Gandhi (Mahatma Gandhi).

About Authors:
Bharathi.V*, SwarnaLatha.D, M.Sreenivasulu
Annamcharya college of pharmacy, newboyana pally, rajampet(M),
kadapa(dt). Andhara Pradesh, India.
*bharu.v.net@gmail.com

ABSTRACT:
Medicinal plants have played an essential role in the development of human culture. Many of the modern medicines are produced indirectly from medicinal plants, for example aspirin. The present study was concentrated on past work reported on the some mussaenda species and study of different activities and phyto constitutions reported on mussaenda species. The genus Mussaenda (rubiaceae) is an important source of medicinal natural products, steroids, flavonoids, glycosides and only a few number of species reported positive for alkaloids and tannins. Many Mussaenda species were reported to possess anti-oxidant, anti-inflammatory in different models, analgesic, antimicrobial, diuretic, antiphlogistic and antipyretic, acute gastroenteritis and dysentery, anti- fertility activity, antiviral property , antibacterial effect rarely for hepato protective activity and wound healing activity.

Clinical Development Services Agency (CDSA) is an extramural unit of THSTI and has been established as a not-for-profit society to provide cost effective, high quality preclinical and clinical product development support services to meet the country's growing healthcare needs. It will tend enterprises - particularly SMEs involved in new technology innovation and facilitate translation of scientific know-how into viable products.

About Authors:
Khayyam Shaikh*, Patwekar Shailesh, Santosh Payghan, John Disouza
Department of Pharmaceutics,
Tatyasaheb Kore College of Pharmacy,
Warananagar, Kolhapur, Maharashtra, India 416113.
*ramzanshek0587@gmail.com

ABSTRACT
During the last two decades there has been a remarkable increase in interest in sustained release drug delivery system. This has been due to various factors viz. the extensive cost of developing new drug entities, expiration of existing international patents, discovery of new polymeric materials suitable for prolonging the drug release, and improvement in therapeutic efficacy and safety achieved by this delivery system. A number of design options are available for the preparation of controlled release formulations to modify oral absorption. Formulation approaches are being explored to enhance bioavailability of poorly water-soluble drugs. One such approach that has been shown significantly enhanced absorption of such drugs is to formulate solid dispersionand then formulate its tablets. Solid dispersion technology can be used to improve the in- vitro and in- vivo dissolution properties of slightly water soluble drugs and to control their dissolution rate. In this current study attempts have been made to formulate sustained release tablets of solid dispersions.