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ABOUT AUTHORS
Kambham Venkateswarlu*,
Department of Pharmaceutics,
JNTUA-Oil Technological and Pharmaceutical Research Institute
Andhra Pradesh,  India
k.v.reddy9441701016@gmail.com

ABSTRACT 
The objective of the present investigation was to formulate and evaluate the mouth dissolving tablets (MDTs) of ketoprofen (KPN) using disintegrants like Crospovidone (CP), Croscarmellose sodium (CCS) and Sodium starch glycolate (SSG) and the effect of disintegrants on drug release was also studied. The powder blend was evaluated for flow properties and found acceptable flow properties. The prepared MDTs were evaluated for post compression parameters such as hardness, friability, weight variation, dispersion time, drug content and in-vitro drug release. Tablets possessing sufficient strength supported by hardness and friability results. The formulation KP6 showed lease dispersion time of 14 sec and it was selected for drug release studies. KP6 showed 99.9% of drug release in 5 min and time taken for 70% of the drug is 2.8 min. Based on the results obtained from the dispersion time and in-vitro dissolution studies, it could be concluded that the concentration of disintegrant is indirectly proportional to the dispersion time and directly proportional to the amount of drug release respectively.

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