Articles

A REVIEW ON NOVEL APPROACHES FOR COLON TARGETED DRUG DELIVERY SYSTEMS

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ABOUT AUTHORS
Sumedha Saxena, Chandan Kumar Singh*, MukeshYadav, Alex Laurel Samson.
Department of Pharmacy, Dr. M.C. Saxena College of pharmacy, Lucknow, (U.P.)

*chandansingh.skic@gmail.com

ABSTRACT
This review mainly focus on targeted drug delivery to the colon is extremely desirable for local treatment of inflammatory bowel disease such as ulcerative colitis, crohn's disease, amoebiasis, colonic cancer as well as for systemic delivery of protein and peptide drugs. The colon is a site where local delivery allows topical treatment of inflammatory bowel disease and systemic delivery of drug can take place. Treatment of colon can be made effective if the drug can be targeted directly into the colon because drug release and absorption should not be take in abdomen and the small intestine and bioactive agents should not be degraded and to allow drug release into the colon. Drug targeting to the colonic area is not only associated with the treatment of colonic ailment locally but also delivering drugs such as protein and peptide for their systemic effects which are degraded and bioavailability is very depressed due to the instability in the GI Tract.

ANTI-ANEMIC ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT SEEDS OF FOENICULUM VULGARE IN PHENYLHYDRAZINE INDUCED ANEMIC RATS

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ABOUT AUTHORS
CHANDRAKANTA KUSHWAH 1*, DEEPANSHU GUPTA 1, ANKUR JOSHI 1, SAPNA MALVIYA 1 & ANIL KHARIA 1
1 Department of pharmacy Modern institute of Pharmaceutical Sciences,
Indore (M.P.), India
chandakushwah0@gmail.com

ABSTRACT
The main objective of this research was to evaluate the anti-anemic activity in hydro-alcoholic extract of seeds of Foeniculum vulgare in phenylhydrazine induced anemic rats. Phenylhydrazine (60mg/kg) was given intraperitoneally in rats for two days to induce anemia. The animal were divided into 5 groups of 6 animal each. Group 1 was known as normal control group, Group 2 was known as anemic control group, Group 3 was known as standard reference control group given with Vit. B12, Group 4 was known as test control-I given with 100mg/kg of hydro-alcoholic extract of seeds of Foeniculum vulgare, Group 5 was known as test control-II given with 200mg/kg of hydro-alcoholic extract of seeds of Foeniculum vulgare. All the test drugs were given for 28 days through oral route once in a day. On 29th day blood was taken out through tail puncture and was subjected to the determination of RBC, Hb and percentage Haematocrit. Both the hydro-alcoholic seeds extract of Foeniculum vulgare and Vit. B12 significantly increase the HB, RBC & percentage Haematocrit level which shows that Foeniculum vulgare seeds exhibits the anti-anemic activity

FORMULATION AND CHARACTERIZATION OF HERBAL LIPSTICK USING COLORED PIGMENT OF PUNICA GRANATUM

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ABOUT AUTHORS
Megha Padiyar1, *Sourabh D Jain1, Deepak Birla1, Jayanti Mukherjee1, Vimukta Sharma2
1Shri Bherulal Pharmacy Institute, Indore (M.P.), India
2BM College of Pharmaceutical Education and Research, Indore (M.P.), India

*sourabhjain072@gmail.com

ABSTRACT:
Herbal Cosmetics are in rising demand in the world market as these are the priceless gift of nature with enhanced activity and lesser or no side effects. The concept of beauty and use of natural cosmetics is as primordial as mankind and civilization. Herbal cosmetics as the name suggests are natural and free from all the destructive artificial chemicals. The present work was aimed to formulate herbal lipstick by using various natural ingredients like concentrated juice of pomegranate seeds (Punica granatum), shikakai, dried ginger powder, lemon juice, coconut oil, bees wax, paraffin wax, strawberry essence, vanilla essence and so on. The formulated herbal lipstick was evaluated and various parameters such as color, melting point, breaking point, force of application, surface anomalies, pH, skin irritation test and aging stability were determined and reported herewith.

ANTI-ANEMIC ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF FRUIT OF ALLIUM TRICOCCUM IN PHENYLHYDRAZINE INDUCED ANEMIC RATS

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PhotoABOUT AUTHORS
DEEPANSHU GUPTA *, CHANDRAKANTA KUSHWAH , ANKUR JOSHI , SAPNA MALVIYA & ANIL KHARIA
Department of pharmacy
Modern institute of Pharmaceutical Sciences, (Shri Prabhat Chandra Kharia Research and Educational Society)
Indore, M.P, India

*guptadeepanshu252@gmail.com

ABSTRACT
This current research was done to bring out the anti-anemic activity in hydro-alcoholic extract of fruit of Allium tricoccum in phenylhydrazine induced anemic rats. The anemia was induced by the administration of Phenylhydrazine (60mg/kg) intraperitoneally in rats for two days. The animals were divided into 5 groups containing 6 animals each. 1st group was served as normal control group, 2nd group was served as anemic control, 3rd group was served as standard reference control administered with Vit. B12 complex, 4th group was served as test control-I administered with 100mg/kg of hydro-alcoholic extract of fruit of Allium tricoccum and 5th group was served as test control-II administered with 200mg/kg of hydro-alcoholic extract of fruit of Allium tricoccum. All the test drugs were given for 28 days daily through oral route. On 29th day blood was withdrawn, through tail puncture and subjected to the estimation of RBC, Hb and percentage Haematocrit. Both the hydro-alcoholic fruit extract of Allium tricoccum and Vit. B12 significantly increase the Haemoglobin, Red Blood Cells & percentage Haematocrit level which conclude that Allium tricoccum fruit exhibits’ the anti-anemic activity.

ADVANCED TECHNOLOGY ON ACCURACY IN DETECTION OF BREAST CANCER

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ABOUT AUTHORS
SUJATHA RAMASAMY 1*, SRIKANTA PRIYADARSHAN PATRA 1,PULAK RANJAN BASAK 1,
1Technology Information, Forecasting and Assessment Council (TIFAC)-DST, New Delhi, India.
*sujathar23@gmail.com

ABSTRACT:
Breast cancer is one of the leading type of cancer in India. Current methods used in detection of cancer like mammography combined with Digital Infrared Imaging can help learn about  earlier stages of cancer with accuracy.The Niramai an Indian startup developed a software with machine learning and artificial intelligence which can detect and sense cancer cells that are 5 times smaller than what has been done presently. The method is non-contact, painless and free of radiation. This method can help detection of cancer in very early stage before showing any suspicious or alarming signs.

ORODISPERSIBLE LIQUISOLID COMPACTS: A NOVEL APPROACH TO ENHANCE SOLUBILITY AND BIOAVAILABILITY

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ABOUT AUTHORS
VINOTH KUMAR P 1,
*RAJALAKSHMI A.N.1, STEPHEN P2
1Department of Pharmaceutics, College Oof Pharmacy, Mother Theresa Postgraduate And Research Institute of Health Sciences, Puducherry-6, India
1 Department of Pharmaceutics, College of Pharmacy, Mother Theresa Postgraduate And Research Institute of Health Sciences, Puducherry-6
, India
2 Formulation Research and Development, Sai Mirra Innopharm Pvt Ltd., Chennai, India

*ocusertraji@gmail.com

ABSTRACT:
Orodispersible liquisolid system is the combination of liquisolid technique and orodispersible system. The poor dissolution rate of water insoluble drug is a major drawback for the development of pharmaceutical dosage forms. The oral absorption of drug is most often controlled by dissolution in the gastrointestinal tract. Liquisolid system has been used to enhance dissolution rate of poorly water-soluble drugs. Orodispersible tablets are given in order to provide fast action by disperse in the mouth, without the need of water and make them compliance for paediatric and geriatric patients and to bypass the liver metabolism.

KETAMINE: A MAGIC REMEDY

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ABOUT AUTHORS
Kshitij Nuwal, Shailja Jain, Kamal S. Rathore
B.N.I.P.S., UDAIPUR

kshitij.nawal10@gmail.com

ABSTRACT:
The largest, longest study conducted on depression treatments, called the STAR*D trial, found that after people tried four antidepressants over the course of five years, about 70% of them were free of depressive symptoms. That’s a lot of trial and error to end at a place where 30% of patients don’t experience remission at all. The STAR*D trial ended in 2014, and despite a clear hole in the market–and a clear patient need–a golden age of new depression treatments still hasn’t arrived. The anesthetic ketamine could offer hope for people who don't have other depression treatment options. The most recent research on ketamine, as well as a statement from experts on its use published in April 2017, finds the drug works quickly, makes dramatic improvements in mood, and can work on people who haven’t gotten better with other depression treatments.

NOVEL DRUG DELIVERY SYSTEMS IN MANAGEMENT OF CARDIOVASCULAR DISEASES

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SHYAMOSHREE BASUABOUT AUTHOR
SHYAMOSHREE BASU
Advanced Cardiac Center,
B.R. Singh Hospital & Centre for Medical Education & Research
Sealdah, Kolkata – 700014 West Bengal

shyamoshree@gmail.com

ABSTRACT
Cardiovascular (CV) diseases like atherosclerosis, angina pectoris, acute myocardial infarction, are a major cause of mortality in the whole world owing to the present day hectic lifestyle. In this review we will concentrate on the various novel drug delivery systems (DDS) like transdermal DDS, micelles, liposomes, nanoparticles (NPs), dendrimers, drug eluting stents (DES) and drug eluting balloons (DEB) that are being used over the years and in present day for the treatment of these diseases.

CANCER CURE: HANDLE GENTLY (NEW HOPES FOR PATIENTS AND RESPONSIBILITIES OF SCIENTISTS)

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ABOUT AUTHORS
Dr. Vishwas
*, B. Chavan
Aditya Jyot Eye Hospital and Foundation
*vishwaschavan2003@yahoo.co.in

ABSTRACT
Cancer is one of the leading causes of morbidity and mortality worldwide. Many patients succumbed to the disease despite best efforts from medical and surgical oncologists. This is because of several challenges like treatment resistance, genetic heterogeneity of tumor cells and high cost of new therapies. It is clear from the recent research that to overcome cancer, a gentler approach is necessary. This approach include controlling inflammatory processes, discovering compounds which can offer minimum resistance from cancer cells, targeting therapy where it is actually needed and increase strength of the patient’s body by non-drug ways like exercise and modulating gut microflora. Scientists can help the patients more directly by devising more clinical level studies and publishing results as much as possible, even negative ones (like failure of a novel drug to treat cancer), to avoid loss of precious time and money. A coordinated effort from clinicians, patients and scientists planning studies at clinical level and publication of data, even negative ones can help defeat cancer, even at advanced metastatic stage IV stage.

ORAL DRUG DELIVERY SYSTEM CHALLANGES TO PEDIATRICS AND CURRENT APPROACHES

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ABOUT AUTHORS
Poonam R. Ithape1*, Priyanka D. Ghadage1, Jayant K.Gadhve1,Akash S.Mali
Gourishankar Institute of Pharmaceutical Education and Research,
Limb, Satara, Maharashtra
*poonamithape6996@gmail.com

ABSTRACT
The focus of present study is to exist a novel methods for pediatric oral drug delivery.To overcome the problems associated with drug administration,toxicity and taste preference the drug designed in such way that it best suits to child age,required treatment,size and physiological condition.Pediatrics differs from adult in many aspects of pharmacotherapy. Palatability is the biggest challenge while designing the pediatric formulation. As the vast no of limitation present in solid formulation there is wide scope in novel research in designing the pediatrics drug delivery system. Novel approaches in oral drug delivery system is somewhat satisfy the challenges but not the give proper solution. To overcome these problems the novel innovativeresearches is going on. The formulation should be designed in such a way that is easy to administer for pediatrics,having dose flexibility and better palatability of drug formulation.

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