Articles

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ABOUT AUTHORS
M. A. Rashid*, R. H. Zuberi
Pharmacognosy Section
Regional Research Institute of Unani Medicine (RRIUM),
Aligarh, UP, India
* marashid212@gmail.com

ABSTRACT
The fruit of Illicium verum Hook. f. of family Magnoliaceae has been utilized therapeutically as medicine as well as a spice. It is used to relieve a number of human ailments, owing to its properties as carminative, stimulant and appetizer. In order to set the quality standards, the market sample of the drug has been identified and standardized on the basis of Pharmacopoeial parameters, such as salient macro and microscopic characters, ash values, solubility, successive extractive values, thin layer chromatographic evaluations and U.V. spectroscopic analysis. Besides qualitative and quantitative estimations, fluorescence analysis of powdered drug has also been carried out in order to set standards for the crude drug.

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C.V.H.Hemavathy*, B. Raj kumar, R. Kiran kumar, G. Hema latha
Department of Pharmacy,
Kottam Institute of Pharmacy,
Erravally X Roads, Mahaboob Nagar
*hemarayudu19@gmail.com

ABSTRACT
Hepatoprotective activity of  by inducing ccl₄ hepatotoxicity. To study the hepatoprotective activity of against CCL4 induced hepatotoxcity. To evaluate the mechanism of hepatoprotection in terms of Liver antioxidant mechanism, Histopathological study. The animals were divided into Four groups of  three animals each. Except the normal group all the other groups received ccl4 in at a dose of 0.1 ml/kg by intraperitoneally for 14 days. Normal groups received plain tween 80 orally.  On the 14^th day all the rats from all the groups were sacrificed, blood was collected from each animal for serum analysis  and their livers were stored  under freezing conditions for the estimation of endogenous anti oxidants and one sample from each group was stored in 10% formalin for histopathological studies.  In bio-chemical studies- Serum analytical methods (AST), (ALT), (Alk.P), (Bil), (TP), (TC). The present findings observed in this study revealed that,glimepirideis natural antioxidant lignin possess significant antioxidant activity against ccl₄ induced hepatotoxicity via antioxidant mechanism. However, further research is required to find out the other possible mechanism of hepatoprotection to conform that  as glimepiridehepatoprotective molecule.

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Akansha Bhandari¹, Nitisha Bhandari^2*
1 Department of Lifesciences,
Shri Guru Ram Rai Institute of Technology and Science, Patel Nagar, Dehradun, India
² Department of Biotechnology, Graphic Era University, Dehradun, India
*nitishabhandari89@gmail.com

ABSTRACT
Modern era diseases bring more challenges and hurdles to the rational drug targeting. However chemotherapy is the most affected area as most reports are related to antibiotics resistance. Although some successes are accounted as new molecules and new structures are keep on synthesizing or either isolated. One such example is Teixobactin which is isolated for Eleftheria terrae, which was found to be active against Staphylococcus and Mycobacterium bacteria. The story of Teixobactin isolation could open new horizon and opportunistic ways for future designing of useful drugs against these resistance bacteria. In the similar context we tried to compile the relevant paper that was published in nature in 2015 into a commentary based critical review.

ABOUT AUTHOR:
Vinay Kumar Singh
General Manager-Technical,
Mikasa Cosmetics Limited,
Ahmedabad, Gujarat
vinay.s@mikasacosmetics.com

Before going into various aspects of Packaging in general, let us understand uniqueness of Cosmetics packaging. The primary aim of packaging is the protection of the product from all hazards it can be exposed to during transport and handling. A cosmetic package, in addition, is also required to be attractive and unique in its features so to trigger “impulse buying” in the end user. Many a times we all have encountered this situation that instead of purchasing medicine from a chemist’s shop, we land in purchasing a Cosmetics that immediately drew our attention. The role of packaging for Cosmetics is not only the prime role of containing but  also to enhance aesthetics. In fact it acts as a silent salesman, acting as an advertisement for the product it contains and influencing consumer’s purchasing choices. It is meant to seduce the consumer and transform products into objects of desire. Cosmetics packaging are attractive and eye-catching as they are extensively decorated. Cosmetic packaging contains everything from the logo of the cosmetic company to the ingredients that the cosmetic contains. It is what gives the consumer their initial opinion about the product. There are various reasons as to why the graphics on the packaging is important to the consumer. Although the packaging is what catches the consumer’s attention. Packaging contributes to the overall feel and image of a brand; high quality packaging signals to consumers that the product inside is high quality. As in other industries, “cosmetics companies try not only to sell a brand to consumers but an image that is associated with certain characteristics or qualities. Even if the products themselves are relatively similar, the packaging can be what sets them apart.

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S. Ashutosh Kumar*, Manidipa Debnath, Venugopal Padala,
Department of Pharmaceutical Analysis and Quality Assurance,
A.K.R.G College of Pharmacy, Nallajerla, West Godavari, A.P
*ashu.mpharm2007@gmail.com

ABSTRACT
Objective: The present work was undertaken with the aim to develop and validate a rapid and consistent RP-HPLC method in which the peaks will be appear with short period of time as per ICH Guidelines.
Method: The HPLC separation was achieved on an Inertsil-C₁₈ ODS column (250 X 4.6 mm; 5 µ) column in an Isocratic Mode. The mobile phase composed of Methanol [HPLC Grade] (55 %) and Buffer (45 %) [pH 4.0 adjusted with triethylamine]. The flow rate was monitored at 1.0 mL/min. The wavelength was selected for the detection was 276 nm.
Results:The retention times found for rabeprazole and mosapride was 2.946 and 4.186 min respectively. The % recovery was 99.98- 100.03 for rabeprazole and 99.97 - 100.02 for mosapride. The linearity was established in the range of 20-80 µg/mL for both rabeprazole and mosapride. The LOD for rabeprazole and mosapride were 0.01 and 0.035 µg/mL respectively. The LOQ for rabeprazole and mosapride were 0.032and 0.11 µg/mL respectively.
Conclusion:The proposed method was adequate sensitive, reproducible, and specific for the determination of rabeprazole and mosapride in bulk as well as in tablet dosage forms.

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M .Manasa Rekha¹*, A. Bharath Kumar¹, T.Mubeena¹, C. Gopinath^2
1Department of Pharmacy Practice,
Annamacharya college of Pharmacy, Rajampet, Andhra Pradesh, India.
²Department of Phytopharmaceuticals and Pharmacognosy,
Annamacharya college of Pharmacy, Rajampet, Andhra Pradesh, India.
manasarekharoyal@gmail.com

Zika virus(ZIKV) is a member of the virus family Flaviviridae and the genus Flavivirus and It is transmitted Aedes mosquitoes like A. aegypti and A. albopictus,which are active at day times^[1,2].

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Nandu Kayande^*, Rakesh Patel
Department of Pharmacy,
OPJS University, Churu, Rajasthan, India
* nandu_kayande@rediffmail.com

ABSTRACT
The traditional Indian medicine - Ayurveda, describes various herbs with anticancer as well as antioxidant properties. Various plant products have been used in treatment of cancer over the years. India is a peninsula of herbal hub, in which ayurvedics system of medicine has flourished as an enlightment in the field of Medicine. Currently medicinal plants have become the paramount source of drug discovery in research for treating diverse form of diseases including Cancer. In this review ayurvedas classical literature and evidence based research data were emphasized to explore the ayurvedic medicinal plants with potent anticancer activity.

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Hemendrasinh J. Rathod*, Dhruti P. Mehta, Jitendra singh Yadav
Department of Pharmaceutics,
Vidyabharti Trust College of Pharmacy,
Umrakh, Gujarat, India.
* hariomh.j.rathod@gmail.com

ABSTRACT
The purpose of writing the review on gastroretentive drug delivery systems (GRDDS) was to accumulate the current literature with a special emphasis on several gastroretentive approaches that have recently become important methodologies in the field of site-specific orally administered sustained/controlled release drug delivery. Technological efforts have been made in research and development of rate-controlled oral drug delivery systems to solve physiological difficulties, like short gastric residence times (GRT) and unpredictable gastric emptying times (GET). GRDDS are an approach to prolong the GRT, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effect. Conventional oral dosage forms pose low bioavailability problems because of their quick gastric transition from the stomach, particularly in case of drugs that are less soluble at an alkaline pH of the intestine. Also, drugs that produce their local action in the stomach get quickly emptied and don’t get sufficient residence time in the stomach. Several efforts have been made to extend the retention time of drug delivery system to reduce the frequency of dose administration. GRDFs not only prolong dosing intervals, but also increase patient compliance beyond the level of existing controlled release dosage forms. This article gives an overview on advantages, disadvantages and characterization of gastroretentive drug delivery systems. This review also includes commercially available gastroretentive products and patents.

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S. Z. Chemate, Vaishali N. Garje*, Shubhada A. Gayake
Department of Pharmaceutics,
Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy,
Ahmednagar, Maharashtra, India
*garjev@gmail.com

ABSTRACT
The aim of present investigation was to design and evaluate, mucoadhesive buccal patch of Metformin hydrochloride, a BCS class II drug, to provide unidirectional sustained drug delivery to the buccal mucosa that has potential to enhance the bioavailability. The patches were prepared using HPMC K4M as a polymer, polyethylene glycol 400 as a plasticizer, by solvent casting technique. The patches, which were prepared by the solvent casting method, were smooth and elegant in appearance; were uniform in thickness, weight and drug content; showed no visible cracks; and showed good folding endurance. The amount of polymer, which significantly influenced characteristics like swelling index, mucoadhesive strength, diffusion study