Articles

  • PharmaTutor
    22 February 2016

    FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE BUCCAL PATCH

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    ABOUT AUTHOR
    S. Z. Chemate, Vaishali N. Garje*, Shubhada A. Gayake
    Department of Pharmaceutics,
    Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy,
    Ahmednagar, Maharashtra, India
    *garjev@gmail.com

    ABSTRACT
    The aim of present investigation was to design and evaluate, mucoadhesive buccal patch of Metformin hydrochloride, a BCS class II drug, to provide unidirectional sustained drug delivery to the buccal mucosa that has potential to enhance the bioavailability. The patches were prepared using HPMC K4M as a polymer, polyethylene glycol 400 as a plasticizer, by solvent casting technique. The patches, which were prepared by the solvent casting method, were smooth and elegant in appearance; were uniform in thickness, weight and drug content; showed no visible cracks; and showed good folding endurance. The amount of polymer, which significantly influenced characteristics like swelling index, mucoadhesive strength, diffusion study

  • 12 February 2016
    CHROMATOGRAPHY BASED CHEMOMETRIC FINGERPRINTING, ISOLATION & QUALITY CONTROL OF PHYTOCHEMICALS

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    ABOUT AUTHOR
    Deepak chowrasia
    Institute of Pharmacy, CSJM University,
    Kanpur, Uttar Pradesh
    chowrasia.deepak@gmail.com

    ABSTRACT
    The present paper explores key consideration of different chromatographic procedures in phytochemical screening of natural products to investigate novel plant based therapeutically active compounds. Sophistication in instrumentation has sharpened the edges of chromatography making the technique an indispensable specialized laboratory as well as industrial tool for isolation, identification, and quality control of herbal products round the globe.

  • 5 February 2016
    REGULATORY CANVAS OF INDIAN PHARMACEUTICAL INDUSTRY: CHALLENGES AND FUTURE

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    ABOUT AUTHORS
    Ayushi Srivastava*, Veena Gupta
    QC Department,
    Akums Drugs & Pharmaceuticals Ltd, Haridwar, India
    *ayushisr@gmail.com

    ABSTRACT
    This article undertakes a review and assessment of regulatory framework in the Indian pharmaceutical industry. Understanding the regulatory circumstances in this segment is extremely critical. The Pharmaceutical industry is one of the major industries in India and it contributes a large share in the overall macro level growth of the India. It is one of the most dynamic sectors in the country but its compliance structure is more complex. The pharmaceutical industry has always been a buoyant sector in the eyes of Investors. With increasing returns, lower risks and high growth, investors are more interested in this industry than ever before.

  • 4 February 2016
    IN VITRO EVALUATION OF ANTIMICROBIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF CHLOROFORM EXTRACT OF GARUGA PINNATA LEAVES

    ABOUT AUTHOR
    Sonia Zaman
    Department of Pharmacy,
    Southeast University, Banani, Dhaka, Bangladesh
    sonia_6995@yahoo.com

    ABSTRACT
    Garuga pinnata     (family: Burseraceae) has many traditional medicinal uses including as astringent, bronchodilator, stomachic, expectorant, pulmonary infection, antidiabetic etc. The present study is based on this plant to evaluate the antimicrobial, antioxidant and cytotoxic properties of G. pinnata leaves. Antimicrobial activity of chloroform extract was evaluated against four Gram positive bacteria Bacillus megaterium, Bacillus subtilis, Sarcina lutea, Staphylococcus aureus and five Gram negative bacteria Escherichia coli, Pseudomonas aeruginosa, Salmonella paratyphi, Shigella dysentriae, Vibrio mimicus, and two common fungus Aspergillus niger, Candida albicans by applying disc diffusion method where Kanamycin disc (30 µg/disc) was used as reference standard. The chloroform extract of G. pinnata leaves showed very good antimicrobial activity against both gram positive and gram negative bacteria and fungus A. niger. The most susceptible microorganism was S. paratyphi (19 mm zone of inhibition) followed by B. subtilis (15 mm zone of inhibition). The antioxidant activity of chloroform extract of G. pinnata leaves was evaluated spectrophotometrically using 1,1-diphenyl-2-picrylhydrazyl (DPPH) for radical scavenging and  ascorbic acid was used as standard. The extract exhibited strong DPPH radical scavenging activity with IC50 value of 57.06 µg/ml as compared to the IC50 value of the reference standard, ascorbic acid (37.21 µg/ml). The cytotoxic activity of G. pinnata  was determined by brine shrimp lethality bioassay using vincristine sulfate as standard. The chloroform extract revealed significant cytotoxic activity with LC50 of 6.607 µg/ml whereas LC50 of Vincristine sulphate was 6.026 µg/ml.

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  • 3 February 2016
    EXTRACTION AND PURIFICATION OF NUCLEIC ACID USING CBNP & PCIA TECHNIQUE

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    About Author
    Nirav Soni
    Department of Quality Assurance,
    A-One Pharmacy College,
    Anasan, Ahmedabad, Gujarat, India
    nirav_sonic@yahoo.com

    ABSTRACT
    Isolation of Nucleic acid easily by Solid Phase Extraction (SPE) and this approach, using commercially available Extraction of nucleic acid column-based kits, requires no toxic chemicals and is a rapid and consistent method for concomitant protein extraction. It is a modern technique useful for separation of Nucleic acid which is  most reliable, less time consuming and separation of  impurities and continuity of reactive products using listed techniques like column-based nucleic acid purification, Nucleic acid methods& ethanol precipitation, DNA separation by silica adsorption. Buffer choice is significant to completely solubilized all proteins in the sample. This technique provides a simple and effective way to analyze protein and nucleic acids simultaneously from the same sample not affecting yield and quality.

  • 27 January 2016
    REVIEW: COMBINED CANDESARTAN CILEXETIL AND PIOGLITAZONE HYDROCHLORIDE THERAPY IN METABOLIC SYNDROME

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  • 22 January 2016
    QUALITY ASSURANCE OF COSMETICS

    ABOUT AUTHOR:
    Vinay Kumar Singh
    General Manager-Technical,
    Mikasa Cosmetics Limited,
    Ahmedabad, Gujarat
    vinay.s@mikasacosmetics.com

    Quality does not merely mean the goodness of a finished product. Of course, the quality of a finished product is the ultimate objective of a company;  this is also what the consumers expect from the product. However, in order to achieve the desired quality in the finished product, it is essential that the whole plan, starting from the purchase of raw materials to the stage where the ultimate product reaches the consumers, has to contribute towards building quality into the product. Even after the product has reached the consumer, the reactions have to be fed back, so that the product enjoys continuous sales. Quality embraces all spheres of activity. In any organisation, the quality function involves all departments and all groups of personnel. No Quality Assurance Department or Manager will be in position to build and control quality. To build quality, each and every personnel; right from Managing Director to Attender need to contribute.

  • 18 January 2016
    PHARMACOLOGY OF COMBINED MESALZINE AND RIFAXIMIN THERAPY TO INFLAMMATORY BOWEL DISEASE

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    ABOUT AUTHORS
    Prajapati Krishna V*, Raj Hasumati A, Jain Vinit C, Prajapati Neelam S.
    Department of Quality Assurance,
    Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India
    *krish1112k@gmail.com

    ABSTRACT
    This review article presents the pharmacology of combined Mesalazine and Rifaximin therapy especially in inflammatory bowel disease. Mesalazine is used as in anti-inflammatory agent, Non-Steroidal. Rifaximin is used in Gastrointestinal Agents, Anti-infective agent. The use of Rifaximin in combination with Mesalazine has been proved to provide beneficial effect in inflammatory bowel disease. The mechanism of Mesalazine and Rifaximin is quite different. Mesalamine and Rifaximin are two different types of drugs offering some symptomatic relief to the IBD patients. Mesalamine treats inflammation, whereas, Rifaximin reduces bio burden.
    Patent for combination of both drugs were approved by WIPO. The main objective of this review article is to provide pharmacological information of combined therapy of Mesalazine and Rifaximin to researcher in development of combined dosage form of this.

  • 11 January 2016
    BIOTECHNOLOGICAL/BIOLOGICAL PRODUCTS: ABOUT ITS STABILITY TESTING

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    ABOUT AUTHORS
    Vivek P. Chavda1*, Dharmesh Shaliya2, Bhargav Patel3, Ashish Gabani4
    1Department of Pharmaceutics, B.K. Mody Government Pharmacy College, Rajkot, Gujarat, India
    2Quality Assurance, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat, India
    3Quality Assurance, Zydus cadila pharmaceuticals Ltd., Ahmedabad, Gujarat, India
    4 Intas Biopharmaceuticals Ltd., Ahmedabad, Gujarat, India
    * vivek7chavda@gmail.com

    ABSTRACT
    The drug delivery systems have made some of the technological advances especially in the case of biopharmaceuticals. When one talks about biotechnological product stability of drug product becomes main culprit due to dynamic nature of drug molecule. This review is grafted using ICH and other regulatory guidelines to provide an overview to stability testing of such molecules.

  • 4 January 2016
    A REVIEW ON: PRESERVATIVES USED IN PHARMACEUTICALS AND IMPACTS ON HEALTH

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    ABOUT AUTHORS
    Sabir M. Shaikh*1, Rajendra C. Doijad1, Amol S. Shete1, Poournima S. Sankpal2
    1 Department of Pharmaceutics, Shree Santkrupa College of Pharmacy, Ghogaon, Karad, Maharashtra, India.
    2 Department of Pharmaceutical chemistry, Shree Santkrupa College of Pharmacy, Ghogaon, Karad, Maharashtra, India.
    *sabirmshaikh17@gmail.com

    ABSTRACT
    For several decades pharmacist have been aware of the need to protect their products against microbial contamination but it is only during the last one or perhaps two decades the serious thought of has been applied to the science of preservation. Preservatives are commonly used as additives in pharmaceutical products, food and cosmetics. Some of the liquid preparation are susceptible to microbial contamination because of the nature of ingredients present in it. Such preparation are protected by preservatives which avoids degradation and alteration of the product.A preservative is a natural or synthetic chemical added to various products which helps to prevent microbial decomposition. Present article deals with the study of ideal properties, classification, mechanism of action, Pharmaceutical applications and its impact on health of various preservatives used in pharmaceuticals.

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