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  • RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTIFICATION OF MEBENDAZOLE IN API AND PHARMACEUTICAL FORMULATIONS

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    ABOUT AUTHORS
    Durgesh Rameshlal Parakh1*, Jayshri K. Madagul1, Harshad Rajendra Mene2, Moreshwar P. Patil1, Sanjay J. Kshirsagar1
    1
    Department of Pharmaceutics,
    MET’s Institute of Pharmacy, Adgaon, Nashik, Maharashtra, India.
    2 Department of Pharmaceutics,
    Government College of Pharmacy, Osmanpura, Aurangabad, Maharashtra, India.
    *aryanparakh57@gmail.com

    ABSTRACT
    A new simple and sensitive RP-HPLC method was developed and validated for quantification of Mebendazole in Active Pharmaceutical Ingredient (API) and pharmaceutical formulation.The gradient RP-HPLC method was developed on Agilent (India) C18 250 × 4.6 mm, 5 μ column using mobile phase as acetonitrile: water pH 3.0 with orthophosphoric acid (90:10 v/v) at a flow rate of 1 mL/min and detection was carried out at 234 nm using UV-Visible detector (UV 3000 M). The method was validated linearity, limit of detection, limit of quantification, precision, ruggedness, robustness, accuracy and specificity were found to be satisfactory. The method was found to be linear in the concentration range of 20-100 μ/mL with correlation coefficient of 0.999. The method was validated according to the ICH guidelines and was proved to be specific, linear, accurate, precise and economical for the analysis of Mebendazole.

  • A SHORT REVIEW ON RHEUMATOID ARTHRITIS (RA)

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    ABOUT AUTHORS
    Sabya Sampad Swain, Nadugopal Bhuyan, Chaitanya Prasad Meher
    Gayatri institute of science & technology (GIST), Gunupur, Rayagada, Orissa
    swainsabhya@gmail.com

    ABSTRACT
    Rheumatoid arthritis is most common disease in India as well as outside India. The Centers for Disease Control and prevention estimates that more than 40 million Americans have some form of arthritis or chronic joint disorder out of them 7 million Americans suffer from arthritis in its most debilitating forms. Arthritis foundation classified rheumatic diseases as inflammatory disorders affecting more & more individuals than any chronic illness. Osteoarthritis is the most common form of arthritis in the United States, affecting about 12% of Americans between the ages of 25 and 74. Rheumatoid arthritis is thought to affect well over 2 million Americans (two to three times more females more than males), whereas juvenile arthritis affects 71,000 children under 16 years of age, 61,000 of whom are females. The presented article is concern with a brief idea about rheumatoid arthritis.

  • HAIR DRESSING

    ABOUT AUTHOR:
    Vinay Kumar Singh

    General Manager-Technical,
    Mikasa Cosmetics Limited,
    Ahmedabad, Gujarat
    vinay.s@mikasacosmetics.com

  • DATA INTEGRITY AND WORLDWIDE REGULATORY GUIDANCE

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    ABOUT AUTHORS
    Rohit A. Patil1*, Shruti N.Patil2

    Department of Regulatory Affairs,
    Supreme Pharma Healthcare Pvt. Ltd. Mumbai, MH, India
    * rohitpharma3250@gmail.com

    ABSTRACT
    Good storage of data & record management are critical elements of pharmaceutical quality system. Data integrity refers to maintaining & assuring the accuracy & consistency of data over its entire life –cycle in compliance with its applicable regulatory requirements.
    Data integrity is mandatory for the regulated pharmaceutical industry, as processing and disposition decisions regarding product quality, safety, efficacy, purity, and compliance with the applicable regulatory requirements are made based on data that is recorded and reported. Data integrity risk should be assessed, mitigated, communicated & reviewed throughout the data life cycle. Healthcare industries should be designed Record-keeping methodologies and systems, in a way that encourages compliance and assures data quality and reliability.

  • REVIEW STUDY ON FACTORS AFFECTING THE PRESCRIPTION PATTERN OF PHYSICIANS

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    About Authors
    Amoah-Binfoh Kenneth1*, Pradhyuman Singh Lakhawat1, Archana Chandra2
    1 SHIATS, Allahabad, UP, India
    2 Dept. of Human Resources, SHIATS, Allahabad, UP, India
    * geokin08@gmail.com

    ABSTRACT
    Prognosis the medical outcome of a corrective prediction, physicians become aware of a particular drug through promotional strategies. If all relevant information received is positive, the drug may be tried on few patients’. As a matter of fact if the outcomes of the trials are acceptable physicians will shift and may be more interested to prescribe the drugs consistent. Prescribing drugs is a standard component of most physicians’ practices. It is an important area of practice that requires appropriate knowledge, skill and professional judgment. To improve patient safety when prescribing, these qualities set out expectations for physicians who prescribe drugs. However in connection with the physician’s prescription pattern, Indian pharmaceutical industry is at a turning point. The pharmaceutical firms have to change their strategies for the challenges ahead. Quality systems, innovation, manufacturing and marketing competence are associate factors that affects physicians prescription pattern. The efficacy of drug discovery process has been reported to have suffered a major transformation. New drug discovery has to be strictly adhere to the tight intellectual property rights to ensure effective and efficient, prescriptions and protections. Further clinical and behavioral characteristics of the patient, research and the pressures from drug firms, high curing effect; habitual or non-habitual choice, behavior pattern of patients, peer influence of physicians (community of physicians) and education and advertising are reviewed factors affecting physician’s prescription pattern.

  • DTK OF MEDICINES FROM BIO-PIRACY: ITS CONSCIENTIOUSNESS BY TKDL OF INDIA

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    ABOUT AUTHORS:
    NG Dhawan*1, Manisha Mavai2, Priyanka Bishnoi3, Raaz K Maheshwari3
    1Amity Institute of Environmental Sciences, Amity University,  Noida, UP, India
    2Department of Botany Physiology, AIIMS, Jodhpur, Rajasthan, India
    3Department of Botany & Biotechnology, University of Rajasthan, Rajasthan, India
    4Department of Chemistry, SBRM Govt PG College, Nagaur, India
    *rkmgreenchem.jaipur@gmail.com

    ABSTRACT
    The genetic resources and indigenous communities traditional knowledge of developing countries is being exploited by the Developed countries in the name of patents for inventions that are derived from genetic  resources. The exploitation of genetic resources and indigenous communities traditional knowledge by the developed countries in the name of patents on the inventions derived from those genetic resources is actually bio-piracy.  Protection of the TK of the local and indigenous communities appears to be one of the most debatable and complex issues. This paper brings out the role of domestic IPR constitution that looks to protect traditional system of medicine and associated TK in Indian sub-continent. Further, it attempts to validate the necessity of introduction of a national TKDL, which can be utilized as an evidence of the 'prior art' by the examiners of patent offices, nationally as well as internationally. Thus, it aims to address the concerns relating to the creation of TKDL in India.

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  • PHARMACOLOGY OF COMBINED RANOLAZINE AND AMIODARONE HYDROHLORIDE THERAPY TO TREAT ATRIAL FIBRILLATION
  • A REVIEW ON: PHYSICOCHEMICAL EVALUATION OF AYURVEDIC MINERAL DRUG TANKAN BHASMA
  • ZERO ORDER AND FIRST ORDER DERIVATIVE SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF MOXIFLOXACIN HYDROCHLORIDE AND KETOROLAC TROMETHAMINE IN SIMULATED TEAR FLUID
  • ADVANCEMENT IN HAIR CARE

    ABOUT AUTHOR:
    Vinay Kumar Singh
    General Manager-Technical,
    Mikasa Cosmetics Limited,
    Ahmedabad, Gujarat
    vinay.s@mikasacosmetics.com

    Before trying to understand advancement in Hair Care, Let us try to know basics about Hair.

    For mammals, fur provides an insulating coat for the conservation of body heat.  The ape RAMAPITHECUS as they left the forest and moved to the Savannah, started a march towards nudity, the hair on the body became sparser and shorter due to adaptability.  The hair was not lost from all over the body. The eyebrows and the eyelashes remained. The hair on the scalp remained as a protection from midday sun, for an animal who can stand and walk on its own two feet. The beard remained as a badge of maleness and in both sexes, the genital and axillary hair remained as it was probably associated with glandular scent producing units.

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