• PharmaTutor
    10 April 2013

    AN OVERVIEW: ON SUPERDISINTEGRANTS

    ABOUT AUTHORS:
    Rahul Tiwari*1, R.C. Jat1, Narendra Sharma1, Arvind Singh Rathore1
    1Shri Ram College Of Pharmacy,
    1Banmore, Morena, India -476444
    *rt30022@gmail.com, arvindsingh.rathore21@gmail.com

    ABSTRACT
    Disintegrants are substances or mixture of substances added to the drug formulation that facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrants. In dosage forms, solid orals gain maximum popularities, about 85%, because of many advantages over others. The therapeutic activity of these formulations is obtained through a typical manner like disintegration followed by dissolution. Hence disintegration has major role for facilitating drug activity and thus gain popularity among other dosage forms. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1-  10 % by weight relative to the total weight of the dosage unit. The present study comprises the various kinds of superdisintegrants which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance. In this review article, more emphasis is given on application and usage of various superdisintegrants comparing with other disintegrants in reference to available scientific studies. The various sources of superdisintegrants and their modification to improve disintegration property are also high-lighted.

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  • 10 April 2013
    miRNAs A NOVEL TARGET FOR ANTICANCER THERAPY

    ABOUT AUTHORS:
    Ketan M. Parmar*, Ritesh N. Sharma
    S.K.Patel College of Pharmaceutical Education & research,
    Department of Pharmaceutical chemistry, GANPAT UNIVERSITY.
    *brave_student_90@yahoo.com

    ABSTRACT
    With the development of technologies to look at the expression levels of hundreds of miRNAs at a time and the clear role of miRNAs in cancers, groups began looking at miRNAs profiles of different cancers,especially the circulating miRNAs. We intended to make sure whether circulating miRNAs could be a promising biomarker of human cancers. Method: We comprehensively searched the Cochrane Library, Medline and EMbase from 1966 to Nov 2009 for the following terms: (“miRNA” or “microRNA”) and (“tumor” or “carcinoma”) and (“plasma” or “serum” or “circulating”). Detailed information was extracted from studies that met the inclusion criteria: blood-based miRNAs in human cancers and studies published in the English literature. Results: The current review show that different researches use different measurement methods which might impact the results;Cancers treatment might have an effect on circulating miRNAs; some miRNAs are multi-faceted RNA; small sample size might produce selection bias. Furthermore, because of the lack of randomized controlled trials and the heterogeneous nature of the available data, no attempt was made to perform quantitativemeta-analyses.
    In this review, based on those researches, circulating miRNAs are promising and difficulties for their future application for diagnosing human cancers.

  • 9 April 2013
    A SHORT REVIEW ON FAST DISSOLVING TABLETS - A NOVEL DRUG DELIVERY SYSTEM

    ABOUT AUTHORS:
    Yedale A.D.*, Waghmare P.V, Kulkarni S.D., Bhusnure O.G., Bhalekar M.S.
    Master of pharmacy, Department of Quality Assurance
    Maharashtra College of Pharmacy, Nilanga, dist. Latur (MS) 413521, India
    *ajayyedale03@gmail.com

  • 8 April 2013
    BEATING CANCER WITH NATURAL PLANT SOURCES

    ABOUT AUTHORS:
    Mohd. Yaqub khan*, Poonam gupta, Vikaskumar verma, Ashish pathak
    Saroj Institute of Technology & Management,
    Ahimamau, P.O. Arjunganj, Sultanpur Road, Lucknow-226002,
    Uttar Pradesh, India
    *khanishaan16@yahoo.com

    ABSTRACT
    Medicinal plants continue to play a central role in the healthcare system of large proportions of the world’s population. This is particularly true in developing countries, where herbal medicine has a long and uninterrupted history of use. Continuous usage of herbal medicine by a large proportion of the population in the developing countries is largely due to the high cost of Western pharmaceuticals and healthcare. Every year, millions of people are diagnosed with cancer, leading to death in a majority of the cases. Specific part of it is formulated into suitable preparations compressed as tablets or made into pills, used to make infusions, extracts, tinctures, etc., or mixed with excipients to make lotions, ointments, creams, etc. Few herbal drugs are subject to legislative control. The plant based drug discovery resulted mainly in the development of anticancer agents including plants (vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan and irinotecan). Beside this there is numerous agents identified from fruits and vegetables can used in anticancer therapy. The agents include curcumin (turmeric), resveratrol (red grapes, peanuts and berries), genistein (soybean), diallyl sulfide, S-allyl cysteine (allium), allicin (garlic), lycopene (tomato), capsaicin (red chilli), diosgenin, 6-gingerol (ginger), ellagic acid (pomegranate), ursolic acid (apple, pears), silymarin (milk thistle), anethol, catechins, eugenol, indole-3-carbinol, limonene, beta carotene, and dietary fiber. In this review active principle derived from natural products are offering a great opportunity to evaluate not only totally new chemical classes of anticancer agents.

  • 8 April 2013
    RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND DESLORATADINE IN COMBINED DOSAGE FORM

    ABOUT AUTHORS:
    Rima M. Bankar*, Dipti B. Patel
    Department of Pharmaceutical Analysis,
    Shree S. K. Patel College of Pharmaceutical Education & Research, Ganpat University,
    Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
    *rima.banker@yahoo.com

    ABSTRACT
    A novel, precise, accurate and rapid isocratic reversed-phase high performance liquid chromatographic/ultraviolet (RP-HPLC/UV) method was developed, optimized and validated for  simultaneous determination of Montelukast Sodium and Desloratadine. The method showed adequate separation for Montelukast Sodium and Desloratadine  and best resolution was achieved with ACE 5 C18 column (150 mm × 4.6 mm i.d, 5 μm particle size) using Acetonitrile-Methanol-Water (15:80:5, v/v) as a mobile phase at a flow rate of 1.0 ml/min and wavelength of 283 nm. The calibration curves were linear over the concentration ranges of 5-50 μg/ml for Montelukast Sodium and Desloratadine. The limit of detection (LOD) and limit of quantification (LOQ) for Montelukast Sodium were 0.33 and 1.01 μg/ml while for Desloratadine were 0.10 and 0.31 μg/ml, respectively. All the analytes were separated in less than 6.0 min. The proposed method could be applied for routinelaboratory analysis of Montelukast Sodium and Desloratadine in pharmaceutical dosage form. Methods were validated statistically and recovery studies were carried out. The proposed methods have been applied successfully to the analysis of cited drug either in pure form or in synthetic mixture of both drugs with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.

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  • 7 April 2013
    COLON TARGETED DRUG DELIVERY SYSTEM

    ABOUT AUTHOR:
    Sunitha Manthena
    Nalla Narsimha Reddy School of Pharmacy,
    Narapally, Hyderabad
    Affiliated to JNTU(H);
    sunithatgk@gmail.com

    INTRODUCTION
    The expenses for developing new drugs are exorbitant. Thus in the present scenario, more emphasis is laid  to develop newer drug delivery technologies, which would ensure better patient compliance, drug efficacy and extends the term of patents of the existing molecules. In the present era, the pharmaceutical industry is facing several challenges due to worldwide competition and growing demand for better products.1

  • 7 April 2013
    REVIEW: SUSTAINED RELEASE DOSAGE FORMS

    ABOUT AUTHOR:
    Abhijeet Welankiwar.
    Govt. College of pharmacy
    kathora naka Amravati (Maharashtra) 444604.
    abhi123welankiwar@gmail.com

    ABSTRACT:
    The oral route of drug delivery is typically considered the preferred and most patient-convenient means of drug administration. With many drugs the basic Goal of therapy is to achieve a steady-state blood or tissue level that is therapeutically effective and nontoxic for an extended period of time. Sustain release system are considered a wiser approach for the drugs with short half-lives and which require repeated dosing, they are easy to formulate and are irrespective of absorption process from gastrointestinal tract after oral administration. The basic objective of these dosage forms is to optimize the delivery of medications so as to achieve a measure of control on therapeutic effect in the face of uncertain fluctuations in the in vivo environment in which drug release takes place. The advances in the formulation technology of modified release dosage form with sustained release oral dosage form has been widely accepted approach as compared to conventional immediate release formulations of the same drug, over which it provides a prolong release of the drug over extended period of time there by giving the better patient compliance and enhanced bioavailability and resulting blood concentration-time profiles of drugs that otherwise suffer from few limitations.

  • 5 April 2013
    REVIEW: TABLET COATING PROCESS

    ABOUT AUTHOR
    Abhijeet Welankiwar
    Govt. College of pharmacy, kathora naka,
    Amravati (Maharashtra) 444604
    abhi123welankiwar@gmail.com

    ABSTRACT:
    Tablet coating is the key step involved in the manufacturing of tablets having controlled release, delayed release profiles. The tablet coating have number of advantages like masking odor, taste, color of the drug, providing physical and chemical protection to drug, Protecting drug from the gastric environment. 3 primary components of tablet coating are tablet properties, coating process and coating composition. Tablets are usually coated in horizontal rotating pan with coating solution is either directly poured or sprayed on to them. The amount of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form. Recent trends in tablet coating focuses on overcoming disadvantage of solvent based coating. This article concerns with the coating process, equipments involved, coated tablets evaluation and specialized coating techniques.

  • 5 April 2013
    DOMPERIDONE NASAL GEL USING NATURAL MUCOADHESIVE AGENT OBTAINED FROM TAMARIND SEEDS

    About Authors:
    Dharmendra Kumar*, Bhanu Priya, Sumedha Bansal,
    Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology,
    Meerut, Uttar Pradesh, India, 250005
    * rvnimiet@gmail.com

    Abstract
    A new Nasal drug delivery system of Domperidone has been developed as decent drug delivery by using natural mucoadhesive agent extract from Tamarindus indica L. The mucoadhesive strength, pH, viscosity and gelling property of this natural mucoadhesive agent was found to be higher in comparison to synthetic polymers, hydroxy propyl methyl cellulose (HPMC) and carbopol which are conventionally used for similar purpose. In vitro drug release characteristic through franz-diffusion cell using excised bovine nasal membrane was also found to be better in comparison to the above synthetic polymers. Now patient friendly, needle free dosage form may replace the Domperidone injections/ tablets in future.

  • 4 April 2013
    SIMULTANEOUS ESTIMATION OF EPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM BY RATIO SPECTRA DERIVATIVE SPECTROPHOTOMETRY METHOD IN SYNTHETIC MIXTURE

    ABOUT AUTHORS:
    Rinku B Patel*1, Paresh U Patel2, Bharat G Patel3, Anil C Patel2
    1Department of Pharmaceutical Analysis, Centre For Health Science Studies, Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
    2Department of Quality Assurance, Centre For Health Science Studies, Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
    3Aspee college of Home Science and Nutrition, S.D.Agricultural University, S.K.Nagar-385506, Banaskantha, Gujarat, India.
    *rinkupatel5890@gmail.com

    ABSTRACT
    Simple, accurate, precise, and sensitive ratio spectra derivative spectrophotometric method for simultaneous estimation of Eperisone hydrochloride (EPE) and Diclofenac sodium(DIC) in synthetic mixture have been developed and validated. The ratio derivative spectroscopic method involves measurement of first derivative amplitude of ratio spectra at 247 nm for EPE and 218.4 nm for DIC as two wavelengths for estimation. Beer's law is obeyed in the concentration range of 2-18 μg/ml for both EPE and DIC. LOD values for EPE and DIC are found to be 0.0634 μg/ml and 0.5386 μg/ml, respectively. LOQ values for EPE and DIC are found to be 0.1921 μg/ml and 1.6321 μg/ml, respectively. The method was validated statistically and recovery studies were carried out. It was found to be accurate, precise and reproducible. The method was applied to the assay of the drugs in synthetic mixture, which were found in the range of 98.0% to 102.0% of the labeled value for both Eperisone hydrochloride and Diclofenac sodium. Hence, the method herein described can be successfully applied in quality control of synthetic mixture.

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