Pharmaceutical Analysis Articles

31 October 2013

SUSTAINED OPHTHALMIC DELIVERY OF MOXIFLOXACIN HYDROCHLORIDE AND KETOROLAC TROMETHAMINE FROM AN ION ACTIVATED IN-SITU GELLING SYSTEM

ABOUT AUTHOR:
Arya K.R.
Department of Pharmaceutics, Regional Institute of Medical Sciences and Research,
MG University, Kottayam
aryajithu@yahoo.com

18 October 2013

A REVIEW ON DETERMINATION OF PRESERVATIVES IN FOOD STUFFS BY DIFFERENT ANALYTICAL METHODS

ABOUT AUTHORS:
V.Surekha¹, V.S.Thiruvengada Rajan¹, C.Madhusudhan Chetty²
¹Dept of pharmaceutical analysis and quality assurance
²Dept.of Biotechnology
Annamacharya college of pharmacy, Rajampet
surekhapharmacy@gmail.com

4 October 2013

DEVELOPMENT AND VALIDATION OF IR SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF AZELASTINE HYDROCHLORIDE IN NASAL SPRAY PREPARATIONS

ABOUT AUTHORS:
^*1Patel Rina B., ²Patel Nilam K.
¹M.pharm(Q.A), Department of Pharmaceutical Sciences
Hemchandracharya North Gujarat University,
²Asst. Professor, Dept. of Pharmaceutical Sciences
Department of Pharmaceutical Sciences, Hemchandracharya North Gujarat University, Patan. Gujarat-384265
*rina_patel2003@yahoo.com

ABSTRACT
A simple, sensitive, rapid, accurate, precise and economical Fourier transform infrared (FTIR) spectrophotometric method has been developed for the determination of Azelastine Hydrochloride (AZH) in nasal spray preparations. The IR spectrophotometric method was based on the determination of AZH by the measurement of the area of the infrared band corresponding to the carbonyl group centred at the band1636 cm^-1. It was present in the AZH but not in Acetonitrile used as solvent and highest intensity was at the area 1701.08-1584.21 cm^-1. The linearity of AZH was obtained in the concentration range of 5-100 μg/ml. The mean % recovery was 99.67 ± 0.57 %. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of method.

27 September 2013

A NOVEL RP- HPLC METHOD DEVELOPMENT AND VALIDATION OF ATORVASTATIN AND FENOFIBRATE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

ABOUT AUTHORS:
¹Vinjam Swathi* ²Nanda Kishore Agarwal
¹M pharmacy, Department of Pharmaceutical Analysis and Quality Assurance, Nimra College of Pharmacy, Jupudi, Vijayawada, A.P, India
²Professor and head of the department of pharmaceutical chemistry, Nimra College Of Pharmacy, Jupudi, Ibrahimpatnam, Vijayawada, A.P, India

24 September 2013

METHOD DEVELOPMENT AND METHOD VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF CEFTAZIDIME PENTAHYDRATE AND TAZOBACTAM SODIUM IN BULK AND DOSAGE FORMS RP-HPLC

ABOUT AUTHORS:
¹S. Amareshwari*, ²Dr. Nanda Kishore Agarwal
¹M.Pharm, Department of pharmaceutical analysis, Nimra College Of Pharmacy
²Professor and head of the department of pharmaceutical chemistry, Nimra College Of Pharmacy,
Jupudi, Ibrahimpatnam, Vijayawada
*amareswarisa@gmail.com

29 August 2013

SPECTROPHOTOMETRIC DETERMINATION OF ROSUVASTATIN CALCIUM IN MARKETED FORMULATION

About Authors
Narsinh N. Potdar*, Pranita P. Kore, Rishikesh V. Antre
Department of Pharmaceutical Chemistry,
JSPM’s Charak College of Pharmacy and Research, Wagholi,
Pune-Nagar Road, Pune-412 207 (India)
*narsinh_potdar@rediffmail.com

Abstract
Three new simple, economic spectrophotometric methods were developed for quantitative estimation of Rosuvastatin Calcium in bulk formulation. First method includes determination of Rosuvastatin Calcium at absorption maxima 252 nm, second method applied was area under curve for analysis of Rosuvastatin Calcium in the wavelength range of 247-257 nm and third method was first order derivative. Beer law obeyed in the concentration range of 5-35 μg/ml for all three methods. The correlation coefficients were found to be 0.974, 0.982 and 0.982by absorption maxima, area under curve and first order derivative spectra. Results of analysis were validated statistically and by performing recovery studies. The mean percent recoveries were found satisfactory for all three methods. The percentage label claim was found in the range of 100.28% to 101.01% .The proposed method was validated statistically and recovery studies.

28 July 2013

FORMULATION AND INVITRO EVALUATION OF 5-FLUOROURACIL MICROCAPSULES BY USING DIFFERENT METHODS OF MICROENCAPSULATION

ABOUT AUTHORS:
S.Shanmugam¹, J. Srikanth Reddy*¹, T. Vetrichelvan²
Adhiparasakthi College of Pharmacy,
Melmaruvathur, 603 319, Tamilnadu, India.
*srikanthjeedipelly@gmail.com

ABSTRCT:
The present study in formulation and evaluation of 5-fluorouracil microcapsules. 5-fluorouracil which is used as a anti cancer drug to treat cancer. The capsules were prepared by coacervation phase separation and emulsion solvent evaporation by using gelatin, sodium alginate and ethyl cellulose. The prepared microcapsules were evaluated with various evaluation methods such as drug content, in-vitro drug release studies, kinetic studies and stability studies as per ICH guidelines were performed. The formulated extended release microcapsules were prepared by powder layering technique. In these formulations containing 150mg of 5-fluorouracil was loaded in it. The particle size and dissolution study of F9 formulation was concluded as the best formulation among other formulations, which showing the most desired drug release. It will be considered as optimized formulation. No significant change was observed in the drug content physical properties and dissolution rate of these micro pellets after the storage period of three months at 40±2ºc and 75±5%RH.

26 July 2013

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR THE SIMULTANEOUS ESTIMATION OF SITAGLIPTIN PHOSPHATE AND METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM

ABOUT AUTHORS:
R.B.Desireddy, *Sure.Lakshmi Sindhuri, A. Charitha, G.Naga sowjanya
Nalanda institute of pharmaceutical sciences,
kantepudi, Sattenapalli.
*suresindhuri@gmail.com

3 July 2013

ANALYTICAL METHOD DEVELOPMENT & VALIDATION FOR ESTIMATION OF TERAZOSIN HYDROCHLORIDE EQUIVALENT TO TERAZOSIN IN TABLET DOSAGE FORM

ABOUT AUTHORS:
Ritobrata Rudra*¹, Sudipta Ganguly², Manabendra Dhua³, Binny sikdar⁴
¹Department of pharmaceutical chemistry, Gupta College of Technological Sciences, Asansol.
²Department of Quality control, Stadmed pharmaceutical pvt ltd, Dumdum, Kolkata.

2 July 2013

DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF ETAMSYLATE AND MEFENAMIC ACID IN HUMAN PLASMA BY RP-HPLC METHOD

About Authors:
Mona Karia*¹, Bhargav Gohel², Bina Thanki³, Darshan Madiya⁴, Shital Faldu⁵
^1,3M.Pharm, Smt. R.D.Gardi B.Pharmacy College. Rajkot, Gujarat, India
²Q.A. Officer, Intas Pharmaceutical Ltd., Ahemdabad.
⁴Assistant Professor of Smt. R.D.Gardi B.Pharmacy College, Rajkot