The Industrial Research and Consultancy Centre (IRCC) co-ordinates and facilitates all research and development activities at the Institute.IIT Bombay is a premier educational and research institute. IIT Bombay is pursuing research that makes a difference.
Applications are invited from the citizens of India for filling up the following temporary position for the sponsored project undertaken in the Department of Biosciences and Bioengineering of this Institute. The position is temporary initially for a period of 1 Year and tenable only for the duration of the project. The requisite qualification & experience etc. are given below
Post : Research Associate (1 Post )
Project Code, Project Title & Funding Agency 16MES003 :
16DBT006 : "Interplay Of Spatio-Temporal Synaptic Drive And Spike Propagation In Shaping Electrical Activity Of Urinary Bladder Smooth Muscle: A Computational Investigation" (DEPTT OF BIOTECHNOLOGY) About the project: As populations age, urinary bladder overactivity is emerging as an increasingly common debilitating condition confronting the elderly. Voiding of the bladder depends on coordinated contraction of the smooth muscle (detrusor smooth muscle, DSM) present in its wall, which in turn depends closely on the electrical activity in the muscle cells. A clear understanding of bladder physiology and pathophysiology rests therefore on a correspondingly clear understanding of the properties of electrical signals generated in DSM. However, these signals are poorly comprehended since the smooth muscle cells are electrically interconnected by low resistance pathways (gap junctions), forming a 3- dimensional syncytium, which renders problematic the interpretation and analysis of signals occurring in them. As an example, while spikes (action potentials) in electrically isolated cells such as skeletal muscle cells generally display a stereotypical waveform, in DSM a variety of spike shapes can be recorded even in a single smooth muscle cell.
Salary : Consolidated salary Rs.36,000/- p.m.(including HRA)
Qualification
Ph.D/MD/MS/MDS or equivalent degree or having 3 years of research, teaching and design and developement experience after MVSc/M.Pharm/ME/M.Tech with at least one research paper in Science Citation Indexed (SCI) journal
Job Profile
Will be required to carry out simulations for a smooth muscle syncytium, particularly in relation to propagation of (i) Action Potentials, (ii) Ca signals in the syncytium. This arena encompasses several sub-domains, and will in itself pose challenges of integration. Chiefly, voltage spread in a bundled syncytium, for action potential propagation as well as following synaptic drive, is to be explored. Various features of action potential spread (e.g. retention/ loss of foot of action potential, extent and efficacy of spatial spread as a function of gap junction conductance and of intensity of spatio-temporal synaptic drive) are to be investigated. Another prime function will be to explore algorithmic mechanisms of incorporating Ca movements between cells in the syncytium, as driven by its concentration gradients. While Ca movement through the cytosol can be driven by diffusion equations, across a gap junction, which is modelled as a resistive link, other mechanisms will need to be conceived. The work will also involve enhancing the efficiency of simulations using the techniques currently available.
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The appointment is for time bound project and the candidate is required to work mainly for the successful completion of the project . The selection committee may offer lower or higher designation and lower or higher salary depending upon the experience and performance of the candidate in the interview.
Candidate possessing the requisite qualification and experience should apply online on or before 12th June, 2017 . Call letters will be sent through e-mail to the candidates shortlisted for interview and will also be displayed on IRCC website. Candidates called for interview will be required to attend at their own expenses.
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