Shree Dhanvantary Pharmacy College

PHARMACOLOGY OF COMBINED MESALZINE AND RIFAXIMIN THERAPY TO INFLAMMATORY BOWEL DISEASE

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ABOUT AUTHORS
Prajapati Krishna V*, Raj Hasumati A, Jain Vinit C, Prajapati Neelam S.
Department of Quality Assurance,
Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India
*krish1112k@gmail.com

ABSTRACT
This review article presents the pharmacology of combined Mesalazine and Rifaximin therapy especially in inflammatory bowel disease. Mesalazine is used as in anti-inflammatory agent, Non-Steroidal. Rifaximin is used in Gastrointestinal Agents, Anti-infective agent. The use of Rifaximin in combination with Mesalazine has been proved to provide beneficial effect in inflammatory bowel disease. The mechanism of Mesalazine and Rifaximin is quite different. Mesalamine and Rifaximin are two different types of drugs offering some symptomatic relief to the IBD patients. Mesalamine treats inflammation, whereas, Rifaximin reduces bio burden.
Patent for combination of both drugs were approved by WIPO. The main objective of this review article is to provide pharmacological information of combined therapy of Mesalazine and Rifaximin to researcher in development of combined dosage form of this.

PHARMACOLOGY OF COMBINED RANOLAZINE AND AMIODARONE HYDROHLORIDE THERAPY TO TREAT ATRIAL FIBRILLATION

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ABOUT AUTHORS:
Patel  Vishakha D*, Raj Hasumati A, Gheewala Nirav K
Department of Quality Assurance,
Shree Dhanvantary Pharmacy College, Kim, Surat
Department of Quality Assurance,
vishuk7293@gmail.com, drharaj@yahoo.com

ABSTRACT:
This review article presents the pharmacology of combined Amiodarone Hydrochloride and Ranolazine therapy specially in Atrial Fibrillation. Amiodarone Hydrochloride is Anti Arrhythmic agent. Ranolazine is a Anti Anginal agent. The Antianginal agent was used in Ischaemia. Amiodarone Hydrochloride is Antiarrhythmic agent and use in Arrhythmia and Atrial fibrillation. If Amiodarone Hydrochloride is administered in large quantities, the condition of patient becomes worse by occurrence of adverse effect of Thyroid toxicity due to presence of Iodine moiety in Amiodarone. The use of Ranolazine in combination with Amiodarone Hydrochloride has been proved to provide beneficial effect in Atrial Fibrillation. The combination therapy has fewer adverse effects. The mechanism of Amiodarone Hydrochloride and Ranolazine is quite different. Amiodarone Hydrochloride inhibit potassium channel and inactivated-state blocker of cardiac sodium channel while Ranolazine inhibit late inward sodium current (INa) in cardiac cell and activated-state blocker of cardiac sodium channel. The combination of both have decrease dose dependent side effect of Amiodarone Hydrochloride. Both the drugs were approved by US government and has been used in Atrial Fibrillation in US.The main objective of this review article is to provide pharmacological information of combined therapy of Amiodarone Hydrochloride and Ranolazine to researcher in development of combined dosage form of this.

A REVIEW ON ANALYTICAL METHODS FOR RANOLAZINE DETERMINATION IN SYNTHETIC MIXTURE

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ABOUT AUTHORS:
Patel Vishakha. D.*, Raj Hasumati, Gheewala Nirav
Department of Quality Assurance,
Shree Dhanvantary Pharmacy College, Kim, Surat
vishuk7293@gmail.com

ABSTRACT
Ranolazine is a piperazine derivative is a new anti-ischemic drug for the treatment of angina.

Ranolazine is to inhibit late INa thus preventing sodium overload of the cell. As a consequence, ranolazine prevents reverse mode sodium–calcium exchange and thus diastolic accumulation of calcium possibly resulting in improved diastolic tone and improved coronary blood flow.

This review article represent the various analytical methods which has been reported for estimation of Ranolazine in synthetic mixture. The spectrophotometric techniques like fluorescent assay and area under curve spectroscopy; Chromatogrraphic methods like HPLC, HPTLC and RP HPLC, GC, LC-MS, LC-MS/MS were reported.

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF LAMOTRIGINE AND CLOZAPINE IN SYNTHETIC MIXTURE BY ABSORPTION CORRECTION METHOD

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ABOUT AUTHORS:
Priyanka P. Atodariya*, Hasumati A. Raj, Vineet C. Jain
*Shree Dhanvantary Pharmacy Collage, Kim,
Surat, Gujarat, India
*atodariya.priyanka@yahoo.com

ABSTRACT:
The simple spectroscopic method has been developed for simultaneous estimation of Lamotrigine and Clozapine in synthetic mixture. Absorbance Correction Method involves the measurement of absorption at two wavelengths 307 nm (lmaxfor Lamotrigine) and 360 nm (lmax for Clozapine). The method was found linear between the range of 1-5 µg/ml for Lamotrigine and 6-30 µg/ml for Clozapine for method. The accuracy and precision was determined and validated statistically. Both the method showed good reproducibility and recovery with %RSD less than 1. The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis for Lamotrigine and Clozapine in bulk and combined dosage form.

SIMULTANEOUS DETERMINATION OF ITOPRIDE HYDROCHLORIDE AND LANSOPRAZOLE IN SYNTHETIC MIXTURE USING SPECTROPHOTOMETRIC TECHNIQUE (FIRST ORDER DERIVATIVE METHOD

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ABOUT AUTHORS:
*Ashif I. Bhim1, Farhana V. Buchiy1, Hasumati A. Raj1, Vineet C. Jain2
1Department of Qaulity Assurane, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India.
2Department of Pharmacognocy, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India.
bhimiqbal23@gmail.com

ABSTRACT
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Itopride Hydrochloride and Lansoprazole in synthetic mixture using first order derivative zero-crossing method. Itopride Hydrochlorideshowed zero crossing point at 278.12nmwhile Lansoprazole showed zero crossing point at 244.58nm. The dA/dλ was measured at 244.12 nm for Itopride Hydrochloride and 278.12nmfor Lansoprazole and calibration curves were plotted as dA/dλ versus concentration, respectively. The method was found to be linear (r2>0.999) in the range of 5-25μg/ml for Itopride Hydrochloride at 244.58nm. The linear correlation was obtained (r2>0.996) in the range of 5-25 μg/ml for Lansoprazole at 278.12 nm. The limit of determination was 0.155μg/ml and 0.059μg/ml forItopride Hydrochloride and Lansoprazole, respectively. The limit of quantification was 0.472μg/ml and 0.179μg/ml for Itopride Hydrochloride and Lansoprazolerespectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows first order derivation zero crossing. The method was successfully applied for simultaneous determination of Itopride Hydrochloride and Lansoprazolein binary mixture.

ABSORBANCE CORRECTION METHOD FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND SIMVASTATIN IN SYNTHETIC MIXTURE

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ABOUT AUTHROS:
Vandana M Patel*, Hasumati A Raj, Vineet C Jain
*Shree Dhanvantary College of Pharmacy,
Kim, Surat, Gujarat, India.
vandanapatel@gmail.com

ABSTRACT
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Amlodipine besylate and Simvastatin in synthetic mixture using Absorbance correction  method. At  360.80  nm (λmax of Amlodipine besylate) Simvastatin has zero absorbance so Amlodipine besylate is directly estimate at 360.80 nm. At 237.60 nm (λmax of Simvastatin) both drugs have some absorbance so Simvastatin is estimate at 237.60 nm using absorbance correction method. The method was found to be linear (r2>0.999) in the range of 5-10 μg/ml for Amlodipine besylate at 360.80 nm. The linear correlation was obtained (r2>0.999) in the range of 5-10 μg/ml for Simvastatin at 237.60 nm. The limit of determination was 0.17 μg/ml and 0.10μg/ml for Amlodipine besylate and Simvastatin, respectively. The limit of quantification was 0. 54μg/ml and 0. 32μg/ml for Amlodipine besylate  and Simvastatin, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99%. The method was successfully applied for simultaneous determination of Amlodipine besylate and Simvastatin in binary mixture.

Applications are invited for appointment of JRF under the scheme of DAE/BRNS at Shree Dhanvantary Pharmacy College

Shree Dhanvantary Pharmacy College is pioneer educational institute and research centre in south Gujarat region. The institute is located in the sprawling campus of 8.32 acres, in Kim, Dist Surat. Shree Dhanvantary Pharmacy College has built its own credentials in a short span of 10 years by catering to students opting for B.Pharm, M.Pharm and Ph.D. The institute is offering postgraduate degree in leading branches of pharmacy like Pharmaceutical Chemistry, Pharmacology, Quality Assurance and Pharmaceutics.

NEED AND APPLICATION OF ANALYTICAL METHOD DEVELOPMENT ON NEW FIXED DOSE COMBINATION OF IRBESARTAN AND ATORVASTATIN IN PHARMACEUTICAL INDUSTRY

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ABOUT AUTHORS:
Paras Virani1,2*, Parul Jain3, Hasumati Raj2, Vineet Jain2
1Research Scholar 2014, Gujarat Technological University, Gujarat
2Quality assurance department, Shree Dhanvantary Pharmacy College, Kim, Surat
3Quality assurance department, Maliba Pharmacy College, Bardoli, Surat
parasvirani@gmail.com

ABSTRACT
Analytical method is primary requirement of the pharmaceutical industry. In pharmaceutical industry various analytical methods is used like chromatography, spectroscopy method, electrochemical method, ion incorporating method, etc. Irbesartan is classified as an angiotensin II receptor type 1 antagonist. Angiotensin II receptor type 1 antagonists are widely used in treatment of diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. Atorvastatin is the most efficacious of the currently available HMG-CoA Reductase inhibitors used in anti lipidemic and also used in atherosclerosis, stroke and cardiac risk. In recently approved new fixed dose combination of Irbesartan and atorvastatin in market of Korea so it require analytical method development which help in industry for new drug delivery system development. This review highlights the role, need and application of various analytical techniques for Irbesartan and atorvastatin combination and their corresponding analytical methods in the pharmaceutical industry.

A REVIEW ON ANALYTICAL METHODS FOR DETERMINATION OF LEVOSULPIRIDE IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL SAMPLE

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ABOUT AUTHORS:
Monika A. Rana*, Hasumati A. Raj
Department of Quality Assurance
Shree Dhanvantary College of Pharmacy,
Kim, Gujarat, India
monika92rana@gmail.com

ABSTRACT
Levosulpiride is an atypical antipsychotic agent. Levosulpiride is the levo enantiomer of sulpiride. It is a substitute benzamide which is meant to be used for several indications: depression, psychosis, somatoform disorders, emesis anddyspepsia. It blocks the presynaptic dopaminergic D2 receptor. Chemically it is N-[[(2S)-1-Ethylpyrrolidin-2-yl] methyl]-2-methoxy-5 sulfamoylbenzamide. several method such as HPLC in human plasma, area under curve, stability by RP-HPLC is done. The parent drug is given in a dose of 400-1800 mg orally. According to literature survey study of impurity profiling of LIVOSULPIRIDE in presence of intermediate has not been reported.

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