Shree Dhanvantary Pharmacy College

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ABOUT AUTHORS:
Priyanka P. Atodariya*, Hasumati A. Raj, Vineet C. Jain
*Shree Dhanvantary Pharmacy Collage, Kim,
Surat, Gujarat, India
*atodariya.priyanka@yahoo.com

ABSTRACT:
The simple spectroscopic method has been developed for simultaneous estimation of Lamotrigine and Clozapine in synthetic mixture. Absorbance Correction Method involves the measurement of absorption at two wavelengths 307 nm (l_maxfor Lamotrigine) and 360 nm (l_max for Clozapine). The method was found linear between the range of 1-5 µg/ml for Lamotrigine and 6-30 µg/ml for Clozapine for method. The accuracy and precision was determined and validated statistically. Both the method showed good reproducibility and recovery with %RSD less than 1. The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis for Lamotrigine and Clozapine in bulk and combined dosage form.

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ABOUT AUTHORS:
*Ashif I. Bhim¹, Farhana V. Buchiy¹, Hasumati A. Raj¹, Vineet C. Jain^2
1Department of Qaulity Assurane, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India.
²Department of Pharmacognocy, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India.
bhimiqbal23@gmail.com

ABSTRACT
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Itopride Hydrochloride and Lansoprazole in synthetic mixture using first order derivative zero-crossing method. Itopride Hydrochlorideshowed zero crossing point at 278.12nmwhile Lansoprazole showed zero crossing point at 244.58nm. The dA/dλ was measured at 244.12 nm for Itopride Hydrochloride and 278.12nmfor Lansoprazole and calibration curves were plotted as dA/dλ versus concentration, respectively. The method was found to be linear (r2>0.999) in the range of 5-25μg/ml for Itopride Hydrochloride at 244.58nm. The linear correlation was obtained (r2>0.996) in the range of 5-25 μg/ml for Lansoprazole at 278.12 nm. The limit of determination was 0.155μg/ml and 0.059μg/ml forItopride Hydrochloride and Lansoprazole, respectively. The limit of quantification was 0.472μg/ml and 0.179μg/ml for Itopride Hydrochloride and Lansoprazolerespectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows first order derivation zero crossing. The method was successfully applied for simultaneous determination of Itopride Hydrochloride and Lansoprazolein binary mixture.

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ABOUT AUTHROS:
Vandana M Patel*, Hasumati A Raj, Vineet C Jain
*Shree Dhanvantary College of Pharmacy,
Kim, Surat, Gujarat, India.
vandanapatel@gmail.com

ABSTRACT
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Amlodipine besylate and Simvastatin in synthetic mixture using Absorbance correction  method. At  360.80  nm (λmax of Amlodipine besylate) Simvastatin has zero absorbance so Amlodipine besylate is directly estimate at 360.80 nm. At 237.60 nm (λmax of Simvastatin) both drugs have some absorbance so Simvastatin is estimate at 237.60 nm using absorbance correction method. The method was found to be linear (r2>0.999) in the range of 5-10 μg/ml for Amlodipine besylate at 360.80 nm. The linear correlation was obtained (r2>0.999) in the range of 5-10 μg/ml for Simvastatin at 237.60 nm. The limit of determination was 0.17 μg/ml and 0.10μg/ml for Amlodipine besylate and Simvastatin, respectively. The limit of quantification was 0. 54μg/ml and 0. 32μg/ml for Amlodipine besylate  and Simvastatin, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99%. The method was successfully applied for simultaneous determination of Amlodipine besylate and Simvastatin in binary mixture.

Shree Dhanvantary Pharmacy College is pioneer educational institute and research centre in south Gujarat region. The institute is located in the sprawling campus of 8.32 acres, in Kim, Dist Surat. Shree Dhanvantary Pharmacy College has built its own credentials in a short span of 10 years by catering to students opting for B.Pharm, M.Pharm and Ph.D. The institute is offering postgraduate degree in leading branches of pharmacy like Pharmaceutical Chemistry, Pharmacology, Quality Assurance and Pharmaceutics.

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ABOUT AUTHORS:
Monika A. Rana*, Hasumati A. Raj
Department of Quality Assurance
Shree Dhanvantary College of Pharmacy,
Kim, Gujarat, India
monika92rana@gmail.com

ABSTRACT
Levosulpiride is an atypical antipsychotic agent. Levosulpiride is the levo enantiomer of sulpiride. It is a substitute benzamide which is meant to be used for several indications: depression, psychosis, somatoform disorders, emesis anddyspepsia. It blocks the presynaptic dopaminergic D2 receptor. Chemically it is N-[[(2S)-1-Ethylpyrrolidin-2-yl] methyl]-2-methoxy-5 sulfamoylbenzamide. several method such as HPLC in human plasma, area under curve, stability by RP-HPLC is done. The parent drug is given in a dose of 400-1800 mg orally. According to literature survey study of impurity profiling of LIVOSULPIRIDE in presence of intermediate has not been reported.

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ABOUT AUTHORS
Grishma Trivedi*, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Gujarat
*trivedigrishma18@gmail.com

ABSTRACT
Pravastatin is an inhibitor of HMG-CoA reductase inhibitor which is used as a hypolipidemic agent to reduce cholesterol level. Chemically, 9-Fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl disodium phosphate. Pravastatin is a drug of choice for the cardiovascular disease. It reduces the coronary and cerebrovascular morbidity and mortality in middle aged individual. Elevated plasma concentration of C-reactive protein are associated with protein increased cardiovascular disease, long term therapy with pravastatin an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter. This review consist of various analytical methods for the determination of pravastatin in various marketed pharmaceutical formulation of biological fluid. Analytical methods consist of various chromatographic methods, spectrophotometer methods and electrical methods reported for determination of pravastatin.

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ABOUT AUTHORS:
Meera V. Lad¹*, Vineet Jain², Hasumati Raj^1
1Department of Quality Assurance,
²Department of Pharmacognosy,
Shree Dhanvantary Pharmacy College, Kim, Gujarat
meeralad235@gmail.com

ABSTRACT:
Bromhexine HCl (BRH)is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus, chemically named 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl benzenemethanamine hydrochloride. According to IUPAC it is 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl] aniline hydrochloride. Because of its physiological importance, the drug has been quantified by exploiting its chemical  and physical properties. Bromhexine is a weak base and its precipitate out at pH value above 6. Bromhexine is a synthetic benzyl amine derivative ofvasicine. The different analytical methods used to quantify the drug as a single active pharmaceutical ingredient include flow injection analysis with ionselectiveelectrodes, inductively coupled plasma mass spectrometry, electrokinetic chromatography, electrochemical oxidation at the glassy carbon electrode, liquid chromatography, liquid gas chromatography, GC with mass detection, and voltammetry. The drug has also been quantified in its combined formulations using HPLC, direct and derivative UV spectrophotometry.

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ABOUT AUTHORS:
Farhana V. Buchiya*, Vineet Jain, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Surat, Gujarat
buchiyafarhana22@gmail.com

ABSTRACT:
Cilnidipine is act as a  dual blocker by blocking L- type of calcium channel  present in vascular smooth muscles and  N- type of calcium channel  present in sympathetic nerve  terminal that supply  blood  vessels. Cilnidipine used in treatment of mostly in hypertension and various cardiovascular diseases except in Angina. Cilnidipine used alone or in combination. This review covers most recent analytical methods such as various spectroscopic methods, chromatographic methods and other methods for determination of cilnidipine in various pharmaceutical dosage forms and biological matrix were reported.

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ABOUT AUTHORS:
Asif I Bhim*, Vineet Jain, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Gujarat, India
bhimiqbal23@gmail.com

ABSTRACT:
Itopride Hydrochloride is a novel, synthesized, gastro prokinetic drug, which stimulates gastrointestinal motor activity through the synergistic effects of dopamine D2-receptor blockade and acetylcholine esterase inhibitors. Chemically, it is N-[[4-[2-(Dimethyl amino) ethoxy] phenyl] methyl]-3, 4-dimethoxy benzamide hydrochloride. Benzamide structure, amide and ether linkages in the drug molecule make it susceptible to degradation. Thus a prokinetic drug like Itopride Hydrochloride by virtue of its efficacy and tolerability could be considered as a drug of first choice and a welcome addition to the drug armamentarium for the symptomatic treatment of NUD (non-ulcer Dyspepsia) and other gastric motility disorders including functional bowel disorders. This review consists of various analytical methods for determination of Itopride Hydrochloride in various marketed pharmaceutical preparation and in biological fluids. Analytical method consists of various spectroscopic methods, chromatographic methods and other methods.