Shree Dhanvantary Pharmacy College

19 March 2015

ABSORBANCE CORRECTION METHOD FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND SIMVASTATIN IN SYNTHETIC MIXTURE

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ABOUT AUTHROS:
Vandana M Patel*, Hasumati A Raj, Vineet C Jain
*Shree Dhanvantary College of Pharmacy,
Kim, Surat, Gujarat, India.
vandanapatel@gmail.com

ABSTRACT
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Amlodipine besylate and Simvastatin in synthetic mixture using Absorbance correction method. At 360.80 nm (λmax of Amlodipine besylate) Simvastatin has zero absorbance so Amlodipine besylate is directly estimate at 360.80 nm. At 237.60 nm (λmax of Simvastatin) both drugs have some absorbance so Simvastatin is estimate at 237.60 nm using absorbance correction method. The method was found to be linear (r2>0.999) in the range of 5-10 μg/ml for Amlodipine besylate at 360.80 nm. The linear correlation was obtained (r2>0.999) in the range of 5-10 μg/ml for Simvastatin at 237.60 nm. The limit of determination was 0.17 μg/ml and 0.10μg/ml for Amlodipine besylate and Simvastatin, respectively. The limit of quantification was 0. 54μg/ml and 0. 32μg/ml for Amlodipine besylate and Simvastatin, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99%. The method was successfully applied for simultaneous determination of Amlodipine besylate and Simvastatin in binary mixture.
6 January 2015

Applications are invited for appointment of JRF under the scheme of DAE/BRNS at Shree Dhanvantary Pharmacy College

Shree Dhanvantary Pharmacy College is pioneer educational institute and research centre in south Gujarat region. The institute is located in the sprawling campus of 8.32 acres, in Kim, Dist Surat. Shree Dhanvantary Pharmacy College has built its own credentials in a short span of 10 years by catering to students opting for B.Pharm, M.Pharm and Ph.D. The institute is offering postgraduate degree in leading branches of pharmacy like Pharmaceutical Chemistry, Pharmacology, Quality Assurance and Pharmaceutics.
26 September 2014

A REVIEW ON ANALYTICAL METHODS FOR DETERMINATION OF LEVOSULPIRIDE IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL SAMPLE

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ABOUT AUTHORS:
Monika A. Rana*, Hasumati A. Raj
Department of Quality Assurance
Shree Dhanvantary College of Pharmacy,
Kim, Gujarat, India
monika92rana@gmail.com

ABSTRACT
Levosulpiride is an atypical antipsychotic agent. Levosulpiride is the levo enantiomer of sulpiride. It is a substitute benzamide which is meant to be used for several indications: depression, psychosis, somatoform disorders, emesis anddyspepsia. It blocks the presynaptic dopaminergic D2 receptor. Chemically it is N-[[(2S)-1-Ethylpyrrolidin-2-yl] methyl]-2-methoxy-5 sulfamoylbenzamide. several method such as HPLC in human plasma, area under curve, stability by RP-HPLC is done. The parent drug is given in a dose of 400-1800 mg orally. According to literature survey study of impurity profiling of LIVOSULPIRIDE in presence of intermediate has not been reported.
22 September 2014

A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION OF PRAVASTATIN IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS

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ABOUT AUTHORS
Grishma Trivedi*, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Gujarat
*trivedigrishma18@gmail.com

ABSTRACT
Pravastatin is an inhibitor of HMG-CoA reductase inhibitor which is used as a hypolipidemic agent to reduce cholesterol level. Chemically, 9-Fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl disodium phosphate. Pravastatin is a drug of choice for the cardiovascular disease. It reduces the coronary and cerebrovascular morbidity and mortality in middle aged individual. Elevated plasma concentration of C-reactive protein are associated with protein increased cardiovascular disease, long term therapy with pravastatin an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter. This review consist of various analytical methods for the determination of pravastatin in various marketed pharmaceutical formulation of biological fluid. Analytical methods consist of various chromatographic methods, spectrophotometer methods and electrical methods reported for determination of pravastatin.
19 September 2014

A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION BROMHEXINE HYDROCHLORIDE IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

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ABOUT AUTHORS:
Meera V. Lad¹*, Vineet Jain², Hasumati Raj¹
¹Department of Quality Assurance,
²Department of Pharmacognosy,
Shree Dhanvantary Pharmacy College, Kim, Gujarat
meeralad235@gmail.com

ABSTRACT:
Bromhexine HCl (BRH)is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus, chemically named 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl benzenemethanamine hydrochloride. According to IUPAC it is 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl] aniline hydrochloride. Because of its physiological importance, the drug has been quantified by exploiting its chemical and physical properties. Bromhexine is a weak base and its precipitate out at pH value above 6. Bromhexine is a synthetic benzyl amine derivative ofvasicine. The different analytical methods used to quantify the drug as a single active pharmaceutical ingredient include flow injection analysis with ionselectiveelectrodes, inductively coupled plasma mass spectrometry, electrokinetic chromatography, electrochemical oxidation at the glassy carbon electrode, liquid chromatography, liquid gas chromatography, GC with mass detection, and voltammetry. The drug has also been quantified in its combined formulations using HPLC, direct and derivative UV spectrophotometry.
18 September 2014

A REVIEW: ANALYTICAL METHODS FOR DETERMINATION OF CILNIDIPINE IN BIOLOGICAL FLUID AND PHARMACEUTICAL DOSAGE FORMS

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ABOUT AUTHORS:
Farhana V. Buchiya*, Vineet Jain, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Surat, Gujarat
buchiyafarhana22@gmail.com

ABSTRACT:
Cilnidipine is act as a dual blocker by blocking L- type of calcium channel present in vascular smooth muscles and N- type of calcium channel present in sympathetic nerve terminal that supply blood vessels. Cilnidipine used in treatment of mostly in hypertension and various cardiovascular diseases except in Angina. Cilnidipine used alone or in combination. This review covers most recent analytical methods such as various spectroscopic methods, chromatographic methods and other methods for determination of cilnidipine in various pharmaceutical dosage forms and biological matrix were reported.

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19 August 2014

A REVIEW: DETERMINATION OF ITOPRIDE HYDROCHLORIDE IN BIOLOGICAL FLUID AND PHARMACEUTICAL DOSAGE FORMS

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ABOUT AUTHORS:
Asif I Bhim*, Vineet Jain, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Gujarat, India
bhimiqbal23@gmail.com

ABSTRACT:
Itopride Hydrochloride is a novel, synthesized, gastro prokinetic drug, which stimulates gastrointestinal motor activity through the synergistic effects of dopamine D2-receptor blockade and acetylcholine esterase inhibitors. Chemically, it is N-[[4-[2-(Dimethyl amino) ethoxy] phenyl] methyl]-3, 4-dimethoxy benzamide hydrochloride. Benzamide structure, amide and ether linkages in the drug molecule make it susceptible to degradation. Thus a prokinetic drug like Itopride Hydrochloride by virtue of its efficacy and tolerability could be considered as a drug of first choice and a welcome addition to the drug armamentarium for the symptomatic treatment of NUD (non-ulcer Dyspepsia) and other gastric motility disorders including functional bowel disorders. This review consists of various analytical methods for determination of Itopride Hydrochloride in various marketed pharmaceutical preparation and in biological fluids. Analytical method consists of various spectroscopic methods, chromatographic methods and other methods.
12 January 2014

SYNTHESIS AND ANTICANCER ACTIVITY OF FLAVONE DERIVATIVES AGAINST ESTROGEN DEPENDENT CANCERS BY RATIONAL APPROCH

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About Authors:
Vanraj Thakor¹*, Jalpa Kher², Fenil Bhayani¹, Bhavini Atodaria¹, Malleshappa Noolvi¹
¹Shree Dhanvantary college of pharmacy, Kim, Surat, Gujarat, India.
²Ashok & Rita Patel institute of Biotechnology, New Vallabh Vidyanagar, Gujarat, India
vanraj7777@gmail.com, jkher3333@gmail.com

Abstract
Aromatase and 17-ßHSD inhibitors are main target of pharmacological interest for the treatment of estrogen dependent cancers. Chalcones, Coumarins, Flavones, Isoflavones have been reported for such inhibition and are used for treatment of breast tumors. So in this topic, Flavone derivatives containing Imidathiadiazole, Thiadiazole, Triazole and benzimidazole hetrocycles synthesised by using simple laboratory reagents like 2-Hydroxy Acetophenone and 4-Hydroxy Benzaldehyde to convert chalcone leads to formation of Flavones by cyclazation using Microwave and followed by attachment of different hetrocycles to form Flavone derivatives and charactrarized by IR, ¹H NMR, ¹³C NMR spectroscopy and elemental analysis. These Flavone derivatives found to exhibit moderate to high inhibitory activity against Estrogen dependent cancers.
17 January 2012

A STUDY ON ANTIULCER ACTIVITY OF ACACIA LEAUCOPHLOEA BARK EXTRACT IN PYLORUS LIGATED RATS

About Authors:
Kapil Patel, Supriya Hazra Das
Department of Pharmacology
Shree Dhanvantary Pharmacy College,
Kim, Surat – 394118,
Gujarat, India

Abstract:
Peptic ulcer is a condition where benign lesions of gastric or duodenal mucosa occur at a site where the mucosal epithelium is exposed to acid and pepsin, due to imbalance between offensive and defensive factors. Acacia leucophloea, a deciduous tree found throughout India is reported to be used in gastric ulcer in traditional medicine. The present study was undertaken to evaluate the anti-ulcer properties of Acacia leucophloea in pylorus ligation ulcer model in rats. Acacia leucophloea was administered for 7 days and on 8^th day 30 min prior to the induction of ulcers. Pretreatment with Acacia leaucophloea showed significant ulcer protection against pylorus ligation ulcer model as compared to control. Thus, the ulcer protective and healing effects of Acacia leucophloea may be due to its effect on both offensive and defensive factors. The present findings suggest that Acacia leucophloea has antiulcer properties.