Uttarakhand

Vacancies for M.Pharm, B.Pharm, D.Pharm as Professor, Associate Professor, Assistant Professor in Dev Bhoomi Group of Institutions

Dev Bhoomi Campus is located in a serene environment, in the picturesque location of the lower Himalayas with a salubrious climate, about 15 Km from Dehradun city, Clock Tower, off Chakrata Road, National Highway NH - 72. The nearest Airport is Jollygrant about 25KMs from the Institute. The sprawling main campus is spread in one piece of the land of 210 Bighas (42 acres), in the surrounding of greeneries, floras & faunas beside the National Forest.

TRANSDERMAL A NOVEL DRUG DELIVERY SYSTEM

About Author:
Dheeraj Fulara
DIT Faculty of Pharmacy, Mussoorie Diversion Road, Dehradun 248009,
Uttarakhand, India.
fularadheerajmpharm@yahoo.com

Abstract-
Transdermal drug delivery systems (TDDS) are dosage forms involves drug transport to viable epidermal and or dermal tissues of the skin for local therapeutic effect while a very major fraction of drug is transported into the systemic blood circulation. The adhesive of the transdermal drug delivery system is critical to the safety, efficacy and quality of the product. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive methods of drug delivery. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. This review article provides an overview of TDDS, its advantages over conventional dosage forms, drug delivery routes across human skin, penetration enhancers, various components of Transdermal patches, types of Transdermal patches, methods of preparation and its physicochemical methods of evaluation.

BUCCAL MUCOSA AS NOVEL DRUG DELIVERY PLATFORM

ABOUT AUTHORS:
N.V Sateesh Madhav, Abhijeet Ojha, *Dheeraj Fulara
DIT Faculty of Pharmacy,
Mussoorie Diversion Road, Dehradun248009,
Uttarakhand, India
*fularadheerajmpharm@yahoo.com

ABSTRACT-
Buccal drug delivery had lately become an important route of drug administration. The rich in vascularization of oral mucosa and its permeability too many drugs make this route an attractive alternative to the oral and parenteral routes for systemic drug delivery. Drug delivery via the oral mucous membrane was considered to be a promising alternative to the oral route. Sublingual route was a useful when rapid onset of action was desired with better patient compliance than orally ingested tablets. Absorption through the buccal mucosa overcomes premature drug degradation due to the enzyme activity and pH of gastrointestinal tract, avoids active drug loss due to presystemic metabolism (First-pass hepatic metabolism), acid hydrolysis and therapeutic plasma concentration of the drug can be rapidly achieved. In the present review, recent advancements and literature regarding mucoadhesivebuccal films is compiled and it suggests that this delivery system can be adopted by various pharmaceutical companies in the future at the large scale because it was the novel frontier in drug delivery technology that provides a very convenient means of takingmedication.

A REVIEW ARTICLE ON TRANSDERMAL DRUG DELIVERY SYSTEM

About Author:
Mohit Dangwal
DIT Faculty of Pharmacy
Dehradun, Uttarakhand
dangwal_mohit@yahoo.in

Abstract
Transdermal drug delivery system (TDDS) is topically administered dosage form in the form of patches which deliver drugs for systemic effects at a predetermined and controlled rate. This review focuses towards the basic facts about the transdermal drug delivery system including the methods of their preparation and some of the recent advancements that have in achieved in this field.

BRAIN DRUG DELIVERY OF NANOPARTICLES BY NASAL ROUTE FOR THE TREATMENT OF DEPRESSION

ABOUT AUTHORS:
Rakhi Choudhary*, Lakshmi Goswami , Preeti Kothiyal
Shri Guru Ram Rai Institute of Technology & Science P.O. Box - 80, Patel Nagar,
Dehradun 248001, Uttarakhand , India
rakhichaudhary211@gmail.com

ABSTRACT
Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism and sadness where these symptoms severely disrupt and adversely affect the person’s life, sometimes to such an extent that suicide is attempted or results. Various Strategies are used for the treatment of depression by giving drug by various routes. Nasal drug delivery is the best route for treatment of CNS disorder as it is the direct route for the delivery of drug.

ADDITIVES IN PHARMACEUTICAL GELS: A REVIEW

ABOUT AUTHORS:
Bhatt Preeti *, Gnanaranjan. G , kothiyal Preeti
Department of pharmaceutics,
Shri Guru Ram Rai Institute Of Pharmacy,
Dehradun-248001, India
*preetibhatt03@gmail.com

ABSTRACT
The motto of writing this review on additives in pharmaceutical gel was to compile the recent literature with special focus on rational approach to topical formulation and basic components used in gel for topical drug delivery systems. Topical drug delivery systems involve the introduction of a drug to the surface of the body, in a formulation which can be absorbed. Topical gels are intended for skin application or to certain mucosal surfaces for local action or percutaneous penetration of medicament or for their emollient or protective action as they show better potential as a vehicle to administered drug topically in comparison to ointment. Additives are inactive ingredients used for structuring dosage form. Selection of topical vehicles depends on various dermatological factors and pharmaceutical factors. Dermatological factors are absorption penetration, skin condition, compatibility, emollient properties. Pharmaceutical factors are stability, solvent properties, emulsifying property.  The choice of suitable exepient for a formulation development is made on the basis of the drug delivery requirements and the particular need to impart sufficient emolliency or other quasi-medicinal qualities in the formulation.

A REVIEW: FAST DISSOLVING DRUG DELIVERY SYSTEM

ABOUT AUTHORS:
Rahul Ratnakar*1, Lakshmi Goswami2, Dr. Preeti kothiyal
1Persuing M.Pharma
2Lecturer/guide
1,2Shri Guru Ram Rai Institute of Technology & Science,
P.O. Box - 80, Patel Nagar,
Dehradun 248001, Uttarakhand, India.
rhl.ratnakar@gmail.com

ABSTRACT
Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance [1]. Mouth dissolving tablets are solid dosage forms containing drugs that disintegrate in the oral cavity within less than one minute the development of mouth dissolving tablets formulation is emerging and gaining popularity because it is easy to administer and leads to better patient compliance [2]. These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds’. According to European Pharmacopoeia, the ODT should disperse/disintegrate in less than three minutes. The basic approach used in development of MDT is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab) (Polyplasdone) etc. which provide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva [3]. MDTs can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients. This is seen to afflict nearly 35% of the general population and associated with a number of conditions, like parkinsonism, mental disability, motion sickness, unconsciousness, unavailability of water etc. To overcome such problems, certain innovative drug delivery systems, like ‘Mouth Dissolving Tablets’ (MDT) have been developed [4].

CHRONOPHARMACEUTICS, “FOR TREATMENT OF ARTHRITIS’’

About Authors:
Rawat Smriti*, Bisht Seema, Kothi Yal Preeti
Shri Guru Ram Rai Institute of Technology & Sciences
Dehradun, Uttarakhand, India.
*smritirawat000@gmail.com

Abstract
Many human biological processes are regulated by circadian rhythms, which follow 24-h cycles and involve the neuroendocrine and immune systems. There is strong evidence for an impact of circadian rhythms in the symptoms of Rheumatoid arthritis, and a number of pro-inflammatory cytokines that exhibit a peculiar rhythmicity in particular serum TNF- α and serum IL-6, and together with other relevant immunological parameters display an elevation in the early morning hours. The increase in nocturnal anti-inflammatory cortisol secretion is insufficient to suppress ongoing inflammation, resulting in the morning symptoms of joint stiffness, pain, and functional disability are characterized.With chronotherapeutics becoming ever more popular, more consideration is being given to the timing of therapy for a number of chronic diseases. The recent surge of interest in the field of chronobiology has highlighted the importance of optimising timing of treatment administration. In this article we discuss the chronobiology of Rheumatoid arthritis and the availability of a new programmed-release.

HNBGU invites M.Pharm, M.Sc for posts of Research Associate, Senior Research Fellow, Junior Research Fellow

Inception of Garhwal University on Dec. 1 st 1973 was the fulfillment of a long cherished dream of the local people .The University was established under the provisions of Uttar Pardesh State Universities Act (Act No. 10 of 1973) on 1.12.1973 and the Act come in force w.e.f. 1.12.1973.

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