Rakhi Choudhary*, Lakshmi Goswami , Preeti Kothiyal
Shri Guru Ram Rai Institute of Technology & Science P.O. Box - 80, Patel Nagar,
Dehradun 248001, Uttarakhand , India

Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism and sadness where these symptoms severely disrupt and adversely affect the person’s life, sometimes to such an extent that suicide is attempted or results. Various Strategies are used for the treatment of depression by giving drug by various routes. Nasal drug delivery is the best route for treatment of CNS disorder as it is the direct route for the delivery of drug.


Bhatt Preeti *, Gnanaranjan. G , kothiyal Preeti
Department of pharmaceutics,
Shri Guru Ram Rai Institute Of Pharmacy,
Dehradun-248001, India

The motto of writing this review on additives in pharmaceutical gel was to compile the recent literature with special focus on rational approach to topical formulation and basic components used in gel for topical drug delivery systems. Topical drug delivery systems involve the introduction of a drug to the surface of the body, in a formulation which can be absorbed. Topical gels are intended for skin application or to certain mucosal surfaces for local action or percutaneous penetration of medicament or for their emollient or protective action as they show better potential as a vehicle to administered drug topically in comparison to ointment. Additives are inactive ingredients used for structuring dosage form. Selection of topical vehicles depends on various dermatological factors and pharmaceutical factors. Dermatological factors are absorption penetration, skin condition, compatibility, emollient properties. Pharmaceutical factors are stability, solvent properties, emulsifying property.  The choice of suitable exepient for a formulation development is made on the basis of the drug delivery requirements and the particular need to impart sufficient emolliency or other quasi-medicinal qualities in the formulation.


Rahul Ratnakar*1, Lakshmi Goswami2, Dr. Preeti kothiyal
1Persuing M.Pharma
1,2Shri Guru Ram Rai Institute of Technology & Science,
P.O. Box - 80, Patel Nagar,
Dehradun 248001, Uttarakhand, India.

Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance [1]. Mouth dissolving tablets are solid dosage forms containing drugs that disintegrate in the oral cavity within less than one minute the development of mouth dissolving tablets formulation is emerging and gaining popularity because it is easy to administer and leads to better patient compliance [2]. These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds’. According to European Pharmacopoeia, the ODT should disperse/disintegrate in less than three minutes. The basic approach used in development of MDT is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab) (Polyplasdone) etc. which provide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva [3]. MDTs can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients. This is seen to afflict nearly 35% of the general population and associated with a number of conditions, like parkinsonism, mental disability, motion sickness, unconsciousness, unavailability of water etc. To overcome such problems, certain innovative drug delivery systems, like ‘Mouth Dissolving Tablets’ (MDT) have been developed [4].


About Authors:
Rawat Smriti*, Bisht Seema, Kothi Yal Preeti
Shri Guru Ram Rai Institute of Technology & Sciences
Dehradun, Uttarakhand, India.

Many human biological processes are regulated by circadian rhythms, which follow 24-h cycles and involve the neuroendocrine and immune systems. There is strong evidence for an impact of circadian rhythms in the symptoms of Rheumatoid arthritis, and a number of pro-inflammatory cytokines that exhibit a peculiar rhythmicity in particular serum TNF- α and serum IL-6, and together with other relevant immunological parameters display an elevation in the early morning hours. The increase in nocturnal anti-inflammatory cortisol secretion is insufficient to suppress ongoing inflammation, resulting in the morning symptoms of joint stiffness, pain, and functional disability are characterized.With chronotherapeutics becoming ever more popular, more consideration is being given to the timing of therapy for a number of chronic diseases. The recent surge of interest in the field of chronobiology has highlighted the importance of optimising timing of treatment administration. In this article we discuss the chronobiology of Rheumatoid arthritis and the availability of a new programmed-release.

HNBGU invites M.Pharm, M.Sc for posts of Research Associate, Senior Research Fellow, Junior Research Fellow

Inception of Garhwal University on Dec. 1 st 1973 was the fulfillment of a long cherished dream of the local people .The University was established under the provisions of Uttar Pardesh State Universities Act (Act No. 10 of 1973) on 1.12.1973 and the Act come in force w.e.f. 1.12.1973.


Papola Vibhooti *, Dr. Kothiyal Preeti
Shri Guru Ram Rai Institute of Technology & Sciences
Dehradun, Uttarakhand, India

The lyophilized wafer developed throughout this review is an effective and versatile drug delivery system for oramucosal application. This has been established from the extensive physicochemical and physic mechanical profiling conducted. Through a screening and selection of polymers, HPC had the lowest gelation characteristics and was therefore suitable for the development of the wafer system. Suitable excipient and polymer combinations were established which allowed for the development of rapidly disintegrating and prolonged release wafer systems. The wafer system containing HPC, lactose, mannitol and glycine had the ability to disintegrate within 30 seconds. The modified wafer system, consisting of pectin cross linked with zinc ions serving as the drug reservoir, and mucoadhesive polymer combination of pectin, carmellose and gelatin, provided effective release of model drug diphenhydramine hydrochloride over approximately six hours. The modification of this technology to provide a prolonged release mucoadhesive system seems promising. It is envisaged that this system will be applicable to many drugs requiring the extended release of bioactive material. Therefore, the lyophilized wafer matrices developed in this study are highly effective in the rapid delivery of drugs, using the oral route as a site of administration.

Applications are invited for Junior Research Fellow in GBPUAT

Applications are invited for the award of one Junior Research Fellow on a consolidated fellowship of Rs. 12 000/ - pm (as per University rules), in the DBT funded Program Mode Support project entitled “Cloning and Functional Validation of Drought Responsive Genes from Eleusine coracana”. The post is tenable for two years or till the completion of the project, whichever is earlier. The appointment shall be given on a six monthly work review basis.

Work as Senior Manager, Manager in Finecure Pharmaceuticals - High Experienced candidates only

Finecure Pharmaceuticals Limited is leading manufacturers and marketers of Pharmaceutical formulations and Nutraceuticals in several therapeutic segments in dosage forms of Tablets, Capsules, Oral Liquids, Dry Syrup, Powders, Injections, Sachet and Effervescent.
The company is WHO GMP certified and also certified for ISO 9001: 2008, ISO 22000: 2005, ISO 14001: 2004, OHSAS 18001: 2007 quality systems towards High Product Quality Assurance, Environment Management System, Occupational cdxHealth and safety.