Uttarakhand

WAFERS TECHNOLOGY – A NEWER APPROACH TO SMART DRUG DELIVERY SYSTEM

ABOUT AUTHORS:
Papola Vibhooti *, Dr. Kothiyal Preeti
Shri Guru Ram Rai Institute of Technology & Sciences
Dehradun, Uttarakhand, India
*papola.vibhooti47@gmail.com

ABSTRACTS
The lyophilized wafer developed throughout this review is an effective and versatile drug delivery system for oramucosal application. This has been established from the extensive physicochemical and physic mechanical profiling conducted. Through a screening and selection of polymers, HPC had the lowest gelation characteristics and was therefore suitable for the development of the wafer system. Suitable excipient and polymer combinations were established which allowed for the development of rapidly disintegrating and prolonged release wafer systems. The wafer system containing HPC, lactose, mannitol and glycine had the ability to disintegrate within 30 seconds. The modified wafer system, consisting of pectin cross linked with zinc ions serving as the drug reservoir, and mucoadhesive polymer combination of pectin, carmellose and gelatin, provided effective release of model drug diphenhydramine hydrochloride over approximately six hours. The modification of this technology to provide a prolonged release mucoadhesive system seems promising. It is envisaged that this system will be applicable to many drugs requiring the extended release of bioactive material. Therefore, the lyophilized wafer matrices developed in this study are highly effective in the rapid delivery of drugs, using the oral route as a site of administration.

Applications are invited for Junior Research Fellow in GBPUAT

Applications are invited for the award of one Junior Research Fellow on a consolidated fellowship of Rs. 12 000/ - pm (as per University rules), in the DBT funded Program Mode Support project entitled “Cloning and Functional Validation of Drought Responsive Genes from Eleusine coracana”. The post is tenable for two years or till the completion of the project, whichever is earlier. The appointment shall be given on a six monthly work review basis.

Work as Senior Manager, Manager in Finecure Pharmaceuticals - High Experienced candidates only

Finecure Pharmaceuticals Limited is leading manufacturers and marketers of Pharmaceutical formulations and Nutraceuticals in several therapeutic segments in dosage forms of Tablets, Capsules, Oral Liquids, Dry Syrup, Powders, Injections, Sachet and Effervescent.
The company is WHO GMP certified and also certified for ISO 9001: 2008, ISO 22000: 2005, ISO 14001: 2004, OHSAS 18001: 2007 quality systems towards High Product Quality Assurance, Environment Management System, Occupational cdxHealth and safety.

FORMULATION AND EVALUATION OF ZIDOVUDINE MICROPARTICLES USING A NOVEL BIO POLYMER FROM THE SEEDS OF BUCHANANIA LANZAN

About Authors:
Neha Tyagi*1, N.V Satheesh Madhav2
1KNGD Modi Institute Of Pharmaceutical Education And Reserach,
Modinagar-2 Uttar Pradesh, India
2Dehradun Institute Of Technology, Faculty Of Pharmacy,
Mussorie Diversion Road Village Makkawala PO Bhagwant pura -248009 Dehradun, Uttrakhand, India
*neha2487@gmail.com

Abstract:
The aim of research work was to isolate a novel bio material from the seeds of Buchanania Lanzan and to evaluate their potential for sustained drug delivery by formulating various micro particles  using  methylene chloride as solvent and bio material by solvent evaporation method. The bio polymer was isolated from the seeds of Buchanania Lanzan by simplified economical method. Four formulations were prepared using bio polymer in different ratios by solvent evaporation method. Acute toxicity studies were done in rats according to OECD guidelines. The formulated micro particles were subjected to various evaluation parameters like particle size , particle shape, entrappement efficacy and invitro drug release studies .on the basis of invitro drug release studies, the formulation with increased amount of bio polymer (FM4) was found to be better than other formulations and it was selected as optimized formulation. Invitro studies revealed that FM4 followed perfect zero first order kinetics release. among the different formulation FM4 showed release of drug for 8 hrs with  88.46%  release.

Career in Indian Medicines Pharmaceutical Corporation Ltd. - GOVERNMENT OF INDIA ENTERPRISE | 9 Posts - Requirements in Production, Quality Analysis, Materials, Medical Representative

The Company (Manufacturing Ayurvedic and Unani Medicines) having obtained drug licence from licensing authority (G.M.P. Certificate  renewed upto 09.06.2015) (Drug licence renewed upto 31.12.2010, applied for renewal) is a GOVERNMENT OF INDIA ENTERPRISE (under the Administrative Control of the Department of AYUSH (Ministry of Health & Family Welfare), Indian Red Cross Building, Red Cross Road, New Delhi).

Requirement of M. S. (Pharm.)/ M. Pharm./ M. Tech. for the post of Jr Research Fellow in UTU

Applications are invited from young and meritorious Indian citizens for filling up one position of JRF funded by the Department of Biotechnology (DBT), Govt. of India. The current project ongoing draw from recent high throughput-drug discovery campaigns, “Antifolate hit-to-lead optimization for PfDHFR-TS inhibition”.

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