Uttarakhand

Vacancies in Indian Drugs & Pharmaceuticals Limited - Govt | Job in Production, QC department

M/s. Indian Drugs & Pharmaceuticals Limited (I.D.P.L.) is a Central Public Sector Undertaking wholly owned by the Govt. of India engaged in manufacture of pharmaceuticals. A Unit of I.D.P.L. situated at Rishikesh requires to engage trained and experienced professionals in following fields on a fixed term contract basis initially for a period of one year which can be extended further on performance basis.

Career Opportunity for Pharmacists ( 28 Posts) to work at SBI - Government job

State Bank of India invites on-line applications from Indian citizens for appointment in the Clerical Cadre posts of Pharmacists, Control Room Operators and Armourers. Candidates are requested to apply on-line between 08.11.2013 and 22.11.2013 through Bank's website statebankofindia.com or sbi.co.in as per the procedure given in HOW TO APPLY below. For applying online, the candidates should have a valid e-mail ID, which should be kept alive during the currency of the project.

COMPARATIVE STUDY ON PROPHYLACTIC USE OF AMOXICILLIN AND CLAVULANIC ACID IN COMBINATION VS CEFTRIAXONE IN NEUROSURGERY WARD OF A TERTIARY CARE HOSPITAL WITH ASSESSMENT OF RESISTANCE RATE IN NEUROSURGERY TO ANTIMICROBIALS

ABOUT AUTHORS:
Neehar Dixit, Arun Kumar, Prashant mathur, Preeti kothiyal
Department of clinical pharmacy
Division of Pharmaceutics
SGRRITS, Patel Nagar
Dehradun, 248001
Uttarakhand, India
neehar.dixit007@gmail.com

ABSTRACT
Antimicrobial agents are among the most commonly prescribed drugs and account for 20% of the hospital pharmacy budget. The present study was designed to observe and compare the prophylactic use of antibiotics (amoxicillin+clavulanic acid vs ceftriaxone) in neurosurgery ward of a tertiary care hospital with assessment of resistance rate in neurosurgery to antimicrobials. Total no of 250 patients were included in the study, in this study inclusion of 232 patients  were receiving amoxicillin+clavulanic acid or Ceftriaxone for prophylaxis in neurosugery. The following parameters were included- reduction of fever, reduction of exudates, depression or disappearance of pathogenic bacteria, overall clinical improvement, complications and length of hospitalization stay. Test of significance of two real ratios was applied and the value of Z indicated (Z=36) which is highly significant hence two ratios are not equal. It implied that ceftriaxone was better than amoxicillin+clavulanic acid. Present study conclude that the resistance rate of penicillins is higher than ceftriaxone in neurosurgery ward. Data  also shows that ceftriaxone is the better choice of treatment and it reduces the hospitalization stay of patients and lead to less burden on patient.

THYROID DYSFUNCTIONS AND ITS MONITORING

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About Authors:
Pathak Namita*, Kothiyal Preeti, Dr. Prashant Mathur
Department of Clinical Pharmacy,
Shri Guru Ram Rai Institute of Technology and Sciences,
Dehradun, Uttarakhand, India, 248001
pathak_namita@ymail.com

Abstract
The prevalence of hypothyroidism is three times higher among women than men. The prevalence in an unselect­ed community population of young, middle aged and elderly individuals is about 1.4 percent and the estimated annual incidence rate is one to two per 1,000 women. Surveys of geriatric populations have yielded estimated prevalence rates for overt hypothyroidism of 0.2 percent to 3 percent. The presentation of symptoms in the elderly may be atypical or absent. The prevalence of subclinical hypothyroidism is estimated to be between 4.0–8.5% of the adult US population without known thyroid disease, and the prevalence increases with age. Up to 20% of women over the age of 60 are estimated to have subclinical hypothyroidism. Caucasians are more likely to have subclinical hypothyroidism than non-Caucasians. The risk is highest in those with type I diabetes mellitus, a family history of thyroid disease or head/neck cancers treated with external beam radiation. Other risk factors include previous radioactive iodine treatment or thyroid surgery. Interestingly, about 20% of patients on thyroid medications are both over re­placed and under replaced. Because of the high incidence of thyroid disease, The American Thyroid Association recommends measuring thyroid function on all adults beginning at age 35 years and every 5 years thereafter noting that more frequent screening may be appropriate in high risk groups. The treatment of subclinical hypothyroidism has been controversial but more recent data suggest there are increased risks of ischemic heart disease in untreated patients and that a more aggressive approach to treat­ ment would be appropriate.7 In contrast, subclinical hyperthyroidism has more well understood risks of atrial fibrillation and flutter and so should be more ag­gressively treated.

NANOSUSPENSION, A NOVEL DRUG DELIVERY SYSTEM VIA, NOSE TO BRAIN DRUG DELIVERY

About Authors:
N.V. Sateesh Madhav, Abhijeet Ojha, Pallavi Uniyal, Dheeraj Fulara*
DIT Faculty of Pharmacy, Mussoorie Diversion Road, Dehradun 248009,
Uttarakhand, India.
*fularadheerajmpharm@yahoo.com

Abstract:
Nanosuspension drug delivery via the nose to brain is considered to be a promising  route. This route is a useful when rapid onset of action is desired with better patient compliance than the other formulations. In terms of permeability, this route is more permeable than the other routes, which in turn is more permeable than the other route. The portion of drug absorbed through this route bypasses the hepatic first-pass metabolic processes giving acceptable bioavailability. Various techniques can be used to formulate nanosuspensions. New nanosupension  technologies address many pharmaceutical and patient needs, ranging from enhanced life-cycle management to convenient dosing for paediatric, geriatric, and psychiatric patients. This review highlights the different kind of nanosuspensions dosage forms, prepration methods of nanosuspensions, stablizers and characterization techniques of nanosuspension. factors affecting the sublingual absorption.

DEVELOPMENT & EVALUATION OF TRANSDERMAL DRUG DELIVERY

ABOUT AUTHOR:
Rakesh Kumar Sati
M.Pharm D.I.T Faculty of Pharmacy
Dehradun Uttarakhand
rakeshsatiq.a@gmail.com

ABSTRACT
Transdermal administration of drugs is an another way of administration that can significantly deliver larger molecules in potent quantities that overcome the problem with the oral administration such as poor bioavailability due to first pass metabolism and sometimes responsible for rapid blood level. Drugs that are given by transdermal route may enhance the potency as well as safety of drugs. One such advance has been the development of transdermal patch delivery systems. Transdermal drug technology specialists are continuing to search for new methods that can effectively and painlessly deliver larger molecules in therapeutic quantities to overcome the difficulties associated with the oral route. Transdermal drug delivery system is the system in which the delivery of the active ingredients of the drug occurs by the means of skin. Skin is an effective medium from which absorption of the drug takes place and enters the circulatory system. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin. The patches have been proved effective because of its large advantages over other controlled drug delivery systems. New transdermal drug delivery system (TDDS) technologies now have been developed that is considered to be helpful in rate controlled delivery of drug that is difficult to administer.

Vacancies for M.Pharm, B.Pharm, D.Pharm as Professor, Associate Professor, Assistant Professor in Dev Bhoomi Group of Institutions

Dev Bhoomi Campus is located in a serene environment, in the picturesque location of the lower Himalayas with a salubrious climate, about 15 Km from Dehradun city, Clock Tower, off Chakrata Road, National Highway NH - 72. The nearest Airport is Jollygrant about 25KMs from the Institute. The sprawling main campus is spread in one piece of the land of 210 Bighas (42 acres), in the surrounding of greeneries, floras & faunas beside the National Forest.

TRANSDERMAL A NOVEL DRUG DELIVERY SYSTEM

About Author:
Dheeraj Fulara
DIT Faculty of Pharmacy, Mussoorie Diversion Road, Dehradun 248009,
Uttarakhand, India.
fularadheerajmpharm@yahoo.com

Abstract-
Transdermal drug delivery systems (TDDS) are dosage forms involves drug transport to viable epidermal and or dermal tissues of the skin for local therapeutic effect while a very major fraction of drug is transported into the systemic blood circulation. The adhesive of the transdermal drug delivery system is critical to the safety, efficacy and quality of the product. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive methods of drug delivery. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. This review article provides an overview of TDDS, its advantages over conventional dosage forms, drug delivery routes across human skin, penetration enhancers, various components of Transdermal patches, types of Transdermal patches, methods of preparation and its physicochemical methods of evaluation.

BUCCAL MUCOSA AS NOVEL DRUG DELIVERY PLATFORM

ABOUT AUTHORS:
N.V Sateesh Madhav, Abhijeet Ojha, *Dheeraj Fulara
DIT Faculty of Pharmacy,
Mussoorie Diversion Road, Dehradun248009,
Uttarakhand, India
*fularadheerajmpharm@yahoo.com

ABSTRACT-
Buccal drug delivery had lately become an important route of drug administration. The rich in vascularization of oral mucosa and its permeability too many drugs make this route an attractive alternative to the oral and parenteral routes for systemic drug delivery. Drug delivery via the oral mucous membrane was considered to be a promising alternative to the oral route. Sublingual route was a useful when rapid onset of action was desired with better patient compliance than orally ingested tablets. Absorption through the buccal mucosa overcomes premature drug degradation due to the enzyme activity and pH of gastrointestinal tract, avoids active drug loss due to presystemic metabolism (First-pass hepatic metabolism), acid hydrolysis and therapeutic plasma concentration of the drug can be rapidly achieved. In the present review, recent advancements and literature regarding mucoadhesivebuccal films is compiled and it suggests that this delivery system can be adopted by various pharmaceutical companies in the future at the large scale because it was the novel frontier in drug delivery technology that provides a very convenient means of takingmedication.

A REVIEW ARTICLE ON TRANSDERMAL DRUG DELIVERY SYSTEM

About Author:
Mohit Dangwal
DIT Faculty of Pharmacy
Dehradun, Uttarakhand
dangwal_mohit@yahoo.in

Abstract
Transdermal drug delivery system (TDDS) is topically administered dosage form in the form of patches which deliver drugs for systemic effects at a predetermined and controlled rate. This review focuses towards the basic facts about the transdermal drug delivery system including the methods of their preparation and some of the recent advancements that have in achieved in this field.

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