Uttarakhand

NOVEL DRUG DELIVERY SYSTEM

About Authors:
Aruna Rastogi
Roorkee College of Pharmacy and UTU
Patanjali Ayurved Ltd, Sr. Chemist
arunarastogi10@gmail.com

1.   INTRODUCTION
1.1 NOVEL DRUG DELIVERY SYSTEM:
The method by which a drug is delivered can have a significant effect on its efficacy. Some drugs have an optimum concentration range within which maximum benefit is derived, and concentrations above or below this range can be toxic or produce no therapeutic benefit at all. On the other hand, the very slow progress in the efficacy of the treatment of severe diseases, has suggested a growing need for a multidisciplinary approach to the delivery of therapeutics to targets in tissues. From this, new ideas on controlling the pharmacokinetics, pharmacodynamics, non-specific toxicity, immunogenicity, biorecognition, and efficacy of drugs were generated. These new strategies, often called drug delivery systems (DDS), are based on interdisciplinary approaches that combine polymer science, pharmaceutics, bioconjugate chemistry, and molecular biology.

FORMULATION AND EVALUATION OF HERBAL CREAM

About Authors:
*1Bhuwanchandra Joshi, 2Mr.Nardev Singh
1
Division of Pharmaceutical Science, SGRRITS
2Assitant Professor
Division of Pharmaceutical Science
Shri Guru Ram Rai Institute Of Technology And Sciences,
Patel Nagar, Dehradun, Uttarakhand
*bhuwan.joshi000@gmail.com

INTRODUCTION
The cosmetics are the utility product used extensively throughout the world for maintaining and improving general appearance of face and other part of body e.g. skin, eye, hair, hand, etc. herbal cosmetics are the preparation which represent cosmetics associated with active bio-ingredients, neutraceuticals and pharmaceuticals.
Cosmetics are products that are used to cleanse and beautify the skin. The first recorded use of cosmetics is attributed to Egyptians in 4000 B.C. Pharmaceuticals are essentially drug products and are defined as products that prevent, mitigate, treat or cure disease and affect the structure or function of the body.

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A NOVEL ANTIDIABETIC DRUG: MIGLITOL: A REVIEW

About Authors:
Rahul kumar Singh
M.Pharm (Quality Assurance)
Sr. Officer Quality Assurance at Shreya Life Sciences Pvt. Ltd.,
Roorkee, Uttarakhand
rahulsingh.qa@gmail.com

Abstract
Miglitol, an oral alpha-glucosidase inhibitor, is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma glucose reduction, miglitol reduce levels of glycosylated hemoglobin in patients with Type II (non-insulin-dependent) diabetes mellitus. Systemic nonenzymatic protein glycosylation, as reflected by levels of glycosylated hemoglobin, is a function of average blood glucose concentration over time. Because its mechanism of action is different, the effect of miglitol to enhance glycemic control is additive to that of sulfonylureas when used in combination. In addition, miglitol diminishes the insulinotropic and weight-increasing effects of sulfonylureas. Miglitol has minor inhibitory activity against lactase and consequently, at the recommended doses, would not be expected to induce lactose intolerance.

DENDRIMERS FOR NOVEL DRUG DELIVERY: AN OVERVIEW

About Authors:
Roopesh Sachan
*1, Prof. Satyanand Tyagi2, Tarun Parashar1, Soniya1, Patel Chirag J*3,Patel Pinkesh3, Rishikesh Gupta4
1
*Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
2
President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
3
Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
4
Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
*roopeshsachan@gmail.com, +91-9557469989, 9236167104

ABSTRACT:
Nanoparticle drug-delivery systems are the popular ones as are able to increase the selectivity and stability of therapeutic agents. However reticuloendothelial system (RES) uptake, drug leakage, immunogenicity, hemolytic toxicity, cytotoxicity, hydrophobicity restrict the use of these nanostructures. These shortcomings are overcome by surface engineering the dendrimer such as Polyester dendrimer, Citric acid dendrimer, Arginine dendrimer, Glycodendrimers, PEGylated dendrimers, etc.The field of Dendrimers has recently emerged as the most commercially viable technology of this century because of its wide-ranging potential applications in many fields such as: healthcare, electronics, photonics, biotechnology, engineering products, pharmaceuticals, drug delivery, catalysis, electronic devices, environmental issues and nanotechnologies. Dendrimer as a drug delivery agent is a promising, safe and selective drug delivery option.

HEALTH BENEFITS OF WHITE TEA: A CLINICAL REVIEW

About Authors:
Prof. Satyanand Tyagi*1, Patel Chirag J2, Pinkesh Patel2,
Chaudhari Bharat2, Tarun Parashar3, Soniya3, Ankur Massey4
*1President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
2
Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
3
Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
4
Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
*sntyagi9@yahoo.com
,+91-9871111375/9582025220

ABSTRACT:
Tea has been used as medicine for centuries. Now modern science is discovering what people in China and throughout the world have long known: tea is good for us. While green and black teas are very healthy, white tea is the least processed tea and has the highest antioxidant levels.
It may be the supreme Drink of Health.By now we can see that white tea has a great range of effects on the body and a tremendous number of benefits to our health. Its supreme power is in preventing disease and disorder. White tea protects against cancer, heart disease, and stroke, the leading causes of death in the industrial world, as well as numerous other conditions. It eases the symptoms of illness and promotes recovery. White tea strengthens the circulatory and immune systems as well as bones and teeth, and builds healthy skin. It is a superb tonic and one of Nature's great gifts. White tea has many other benefits to offer. It may reduce blood sugar and help prevent and alleviate the symptoms of diabetes. It reduces stress and increases energy. White tea may or may not aid in weight-loss. Studies suggest tea may increase metabolism and encourage the body to burn more fat, but a balanced diet and regular exercise are more likely to produce results. Still, adding white tea to our weight-loss plan can't hurt. Generally two cups of white tea is recommended per day for heart health and gastro-intestinal health and to get other health benefits. The aim of present article is to enumerate various health benefits of white tea especially its role in prevention of cardio-vascular diseases. An attempt is also made to focus or highlights on history, contents, manufacturing, production, varieties as well as recent studies as related to clinical uses of white tea.

CLINICAL SPECTRUM OF CITRULLINE-A NON ESSENTIAL AMINO ACID PRESENT IN WATERMELON: AN OVERVIEW

About Authors:
Gaurav Singh*1, Prof. Satyanand Tyagi2, Patel Chirag J3, Patel Pinkesh3, Tarun Parashar1, Soniya1
1*Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
2President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
3Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
*gaurav.hipr@gmail.com, +91-8057832184/9236167104

ABSTRACT:
Citrulline is a non-essential amino acid, meaning that the body can manufacture it from other nutrients. Within the body, citrulline is converted to the amino acid L-arginine i.e. citrulline acts as a precursor of amino acid arginine.  Some of the proposed uses of citrulline supplements are based on raising levels of arginine. Citrulline also plays a role in a physiological process called “the urea cycle,” in which toxic ammonia is converted to urea. Citrulline boosts our energy levels by lowering blood lactate concentration. It also enhances the process of elimination of ammonia. Although citrulline is not coded for by DNA directly, several proteins are known to contain citrulline as a result of a posttranslational modification.


PHARMACEUTICAL AND INDUSTRIAL APPLICATIONS OF ROBOTS IN CURRENT CLINICAL SCENARIO: A RECENT REVIEW

About Authors:
Roopesh Sachan1*, Prof. Satyanand Tyagi2, Tarun Parashar1, Soniya1, Patel Chirag J3, Patel Pinkesh3, Devesh Kaushik4
1*Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
2President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
3Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
4Territory Business Manager, Diabetes Division, Abbott Healthcare Private Limited, Okhla, New Delhi, India- 110020.
*roopeshsachan@gmail.com, +91-9557469989, 9236167104

ABSTRACT:
In the world of pharmaceuticals, there is a vital role for robotics to play in the complicated processes of research and development, production, and packaging. Justification for robots ranges from improved worker safety to improved quality. Speeding up the drug discovery process is another benefit of robotics. Drug Production Robotics plays an important role in the manufacture of pharmaceutical drugs because, unlike other industries, pharmaceuticals demand higher speed and accuracy. Devices such as syringes, inhalers, IV bags and diabetes testing kits are made with the help of robotics. There is a great potential for the use of robotics systems in the pharmaceutical industry and pharmaceutical companies are gradually injecting more robotic systems into their operations.

PROBABLE ROLE OF ENZYMES BACE1 AND BACE2 IN FIGHTING WITH ALZHEIMER’S DISEASE: A NEURO CLINICAL REVIEW

About Authors:
Patel Chirag J*1, Pinkesh Patel1, Prof. Satyanand Tyagi2, Tarun Parashar3, Soniya3, Roopesh Sachan3, Gaurav Singh3
1Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
2President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
3Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
*chirag.bangalore@gmail.com, +91-8000501871

ABSTRACT:
Alzheimer's disease is a progressive neurologic disease of the brain leading to the irreversible loss of neurons and the loss of intellectual abilities, including memory and reasoning, which become severe enough to impede social or occupational functioning. Alzheimer's disease is also known as simply Alzheimer’s, and Senile Dementia of the Alzheimer Type (SDAT). During the course of the disease plaques and tangles develop within the structure of the brain. This causes brain cells to die. Patients with Alzheimer's also have a deficiency in the levels of some vital brain chemicals which are involved with the transmission of messages in the brain - neurotransmitters. Alzheimer's disease is the most common form of dementia. The disease gets worse as it develops - it is a progressive disease. There is no current cure for Alzheimer's, although there are ways of slowing down its advance and helping patients with some of the symptoms. Alzheimer's is also a terminal disease - it is incurable and causes death. According the National Institute on Aging, there are estimated to be between 2.4 million and 4.5 million Americans who have Alzheimer's. β-Secretase is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extra cellular protein domain and may function as a dimer.

Beta-secretase 1 (BACE1) also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2) is an enzyme that in humans is encoded by the BACE1 gene.Beta-secretase 2 is an enzyme that in humans is encoded by the BACE2 gene. BACE2 is a close homolog of BACE1, a protease known to be an important enzyme involved in the cellular pathways that some believe lead to Alzheimer's disease. The aim of present article is to provide in depth knowledge about probable role of enzymes BACE1 and BACE2 in the management of Alzheimer's disease (AD). An attempt is also made to focus on general overview of Alzheimer’sdisease.

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