Uttarakhand

REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM

About Authors:
Bhuvnesh*1, G.Gnanarajan1, Preeti Kothiyal1
Department of Pharmacy, Shri Guru Ram Rai Institute of Technology & Science P.O. Box
80, Patel Nagar , Dehradun 248001, Uttarakhand , India1
*bhuvnesh.grg89@gmail.com

Abstract
Pulsatile drug delivery systems (PDDS) are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site. A pulsatile drug release, where the drug is released rapidly after a well defined lag-time, could be advantageous for many drugs or therapies.A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time so as to match body’s circadian rhythms with the release of drug which increases the efficacy and safety of drugs by proportioning their peak plasma concentrations during the 24 hours in synchrony with biological rhythm. Pulsatile release systems can be classified in multiple-pulse and single-pulse systems.  Various techniques are available for the pulsatile delivery like pH dependent systems, time dependent systems, etc. A popular class of single-pulse systems is that of rupturable dosage forms. Advantages of the pulsatile drug delivery system are reduced dose frequency; reduce side effects, drug targeting to specific site like colon and many more. Now in market varies technologies of pulsatile drug delivery system like Pulsincap, Diffucaps etc. are launched by pharmaceutical companies.

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