A Review on Lyophilization: A Technique to Improve Stability of Hygroscopic, Thermolabile Substances
PharmaTutor (November - 2017)
ISSN: 2347 - 7881
(Volume 5, Issue 11)
Received On: 10/07/2017; Accepted On: 14/07/2017; Published On: 01/11/2017
Shivanand *A, Sayantan Mukhopadhayaya
Division of Pharmaceutical Sciences
Dehradun, Uttarakhand, India.
The active pharmaceutical ingredient that is thermolabile and moisture sensitive in nature generally degraded in atmospheric condition and thus have reduced stability and self-life. Lyophilization is one of those techniques which is utilized effectively to improve such critical condition. It is the one of the emerging technology in the modern era, which is effectively involved in the preparation of several antibiotics (e.g., chloramphenicol, doxycycline) and anti-cancer drugs (e.g., doxorubicin, epirubicin). This technique effectively utilized the phenomenon of sublimation to obtained primary dried product followed by removal of excess amount of moisture by modulation of heat. This technique not only improved self-life of the drug but also provides fast reconstitution and reduced the cost of storage and shipping..
How to cite this article: Shivanand A, Mukhopadhayaya S; A Review on Lyophilization: A Technique to Improve Stability of Hygroscopic, Thermolabile Substances; PharmaTutor; 2017; 5(11); 28-39