HISTORY OF CATIONIC VS ANIONIC: IN NASAL DRUG DELIVERY SYSTEM
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ABOOUT AUTHORS:
Manu Sharma1, Shikha Chaudhary1, Dharmendra Kumar2*
1 R.V.Northland institute, greater Noida, Dadri, UP, India
2Brahmanand Group of Institution, 195, Khurja G.T Road, Buldshahar Uttar Pradesh, India.
*rvnimiet@gmail.com
ABSTRACT
Chitosan as cationic and pectin as anionic are natural polysaccharides which show great potential in nasal drug delivery system. Chitosan’s are strongly poly-cationic. They are derivatives of poly-N-acetyl-D-glucosamine. Chitosan’s have positive charge that is responsible for mucoadhesion and play an important role in nasal drug delivery system Pectin’s have several structural elements: Homogalactouronan are smooth and Rhamnogalactouronan are hairy which play a very important role.By methyl esterifications, pectin’s are divided in two types: High methoxypectin’s and low methoxypectin’s. Low methoxypectin’s are very important in the formulation of nasal gel, because they have properties to form the gel with calcium ion (Ca2+).

The first hospital associated with King George's Medical University was built in 1914, and was called King George Hospital. The funds allocated to the college could hardly be expected to cover the cost of a hospital on a comparable scale. Thus this task was undertaken by the Government of India. The building was again designed by Sir Swinton Jacob after making a spot study of great medical centres in Europe and adapting it the needs of this country.
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