Uttar Pradesh

TRANSDERMAL GEL OF MICONAZOLE NITRATE

About Authors:
DHIRAJ YADAV
BABU BANARASI DAS UNIVERSITY,
LUCKNOW
dhirajyadav06@gmail.com

ABSTRACT
Miconazole is the antifungal drug, has been used in the treatment of fungal infection of skin and also in yeast infection. In order to decrease the skin rashes, skin irritation, and also for best effect on the skin, miconagol gels have been developed. This study was conducted to develop a gel formulation of miconazole using four types of gelling agents: carbopol, carboxymethylcellulose sodium (Na CMC) and sodium alginate. Effect of penetration enhancer (propylene glycol) on the release has been studied. The gels were evaluated for physical appearance, rheological behaviour, drug release and stability. The drug release from all gelling agents through a standard cellophane membrane was evaluated using Keshary-Chien diffusion cell. All batches of gels showed acceptable physical properties concerning colour, homogeneity, consistency, spreadability and pH value.
Among all the gel formulations, carbopol showed superior drug release than followed by Na CMC, and sodium alginate. Drug release decreased with increase in polymer concentration. Drug release was not linearly proportional with the concentration of penetration enhancer or co-solvents. Stability studies showed that the physical appearance, rheological properties, and drug release remained unchanged upon storage for two months at ambient condition.

ALOES SPECIES- A COMPREHENSIVE REVIEW

About Authors:
Krishn Kumar Agrawal*, Kishan Singh, Bhupesh Chander Semwal
Institute of Pharmaceutical Research GLA University,
Mathura-281403 (U.P.) India.
*Krishn.agrawal@rediffmail.com

ABSTRACT:
Medicinal plants have been a major source of therapeutic agents since ancient times to cure human disease. Aloes species (family-Liliaceae) is a widely used herbaceous, shrubby, arborescent, perennial or xerophytic succulents medicinal plant cultivated throughout India and popular in various indigenous system of medicine like Ayurveda, Siddha, Unani and Tibb. Traditionally the juice of aloe is used as bitter, laxative, purgative and cathartic. They are also useful in jaundice, dyspepsia, piles, skin disease, abotificient, trophic ulcer, wounds healing and many more ailments. The present review is therefore, an effort to give a detailed survey of the literature on pharmacognosy, phytochemistry and pharmacological activities of the plant.

PRELIMINARY PHYTOCHEMICAL AND IN-VITRO ANTHELMINTIC SCREENING OF HIBISCUS ROSA-SINENSIS LINN. FLOWER EXTRACTS (FAMILY: MALVACEAE)

About Author:
Krishn Kumar Agrawal*, Jeetendra Kumar Gupta, Anju Verma, Kishan Singh
Institute of Pharmaceutical Research,
GLA University 17-Km. stone, NH-2 Mathura-Delhi Highway,
P.O. Chaumuhan, Mathura-281406 (U.P.) India
*krishn.agrawal@rediffmail.com

Abstract
The objective of the present study to investigate the anthelmintic activity of aqueous and ethanolic extract of flower of Hibiscus rosa-sinensis L. (family: Malvaceae) against Indian earthworms (Pheretima posthuma). The preliminary phytochemical screening of Hibiscus rosa-sinensis showed the presence of sterols, glycosides, alkaloids, proteins, mucilage and flavonoids. Various standards such as Piperazine citrate, Albendazole and Pyrantel pamoate at concentration of 20mg/ml were used to compare anthelmintic activity with the extracts at the same concentration in terms of paralysis time and death time of worms. The result revealed the potential usefulness of aqueous and ethanolic extract of Hibiscus rosa-sinensis flower against helminthiasis infection.

Pharmaceutical Process Validation: Emplication of New FDA Guidelines

About Author:
Ashutosh Gupta
B.Pharm, kanpur university
22ashutoshgupta22@gmail.com

Abstract
This summary represents the Food and Drug Administration’s (FDA’s) current thinking on this topic. It does not create or confer any rights for or on any person and does not operate to bind FDA or the public. You can use an alternative approach if the approach satisfies the requirements of the applicable statutes and regulations. If you want to discuss an alternative approach, contact the FDA staff responsible for implementing this guidance.

Application are invited for the post of Project Officer (SAM) in Bharat Immunologicals & Biologicals Corporation Limited

Bharat Immunologicals & Biologicals Corporation Limited (BIBCOL) a government of India Undertaking, under administrative control of Department of Biotechnology, Ministry of Science & Technology, is a list company and is located in Chola, Bulandshahr (U.P.), about 12 Km from Bulandshahr town and 70 Km from Delhi.

MOLECULAR CHARACTERIZATION OF A BEGOMOVIRUS ASSOCIATED WITH CLERODENDRON INERME

About Authors:
Sanjay Kumar Yadav*1, Anjana Yadav1, Shahana Majumder2
*1Dept of Pharmaceutical Chemistry, B.B.S. Institute of Pharmaceutical & Allied Sciences, Greater Noida, (U.P.), India
1Dept of Biotechnology, Chhatrapati Sahu Ji Maharaj University, Kanpur, (U.P.), India
2Dept of Biotechnology, Sharda University, School of Engineering and Technology,
Greater Noida, (U.P.), India
*sanjay_yadav3333@yahoo.co.in

ABSTRACT
Viruses are pathogens with an extremely narrow host range. Their phylogenetic origin is vague, tough it has always been considered that viruses are genes that became vagrant after having excluded themselves of the host’s or a related species’ genome (Anderson et.al., 2004). Viruses are usually units consisting of nucleic acids and coat proteins called capsids. Viroids consist only of RNA, i.e. they contain no protein at all. Except for a few cases, Viruses have no energy metabolism of their own. Consequently, they cannot perform syntheses and are thus unable to replicate themselves. Depending on their host species, it is distinguished between plant viruses multiplying almost exclusively within plant cells, bacterial viruses (bacteriophages) that depend on living bacteria, and animal viruses. The genetic information of viruses is either encoded by single-stranded RNA (Most plant viruses), double-stranded RNA (Wound tumor viruses), single-stranded DNA (Gemini viruses) or double stranded DNA (Cauliflower mosaic virus). Based on the shape of the viruses particle, it is distinguished between rod shaped and icosahedral viruses with a capsid that seem almost spherical. Viruses’ cause many disease in humans of international importance for example  smallpox polio, hepatitis etc. viruses cause also many important plant disease and are responsible for huge loss in crop production and quality in all part of the world. Around 25 years ago, when genomic properties of geminiviruses were studied, many scientists regarded them as ‘friends of humans’, because of their  potential as gene transfer vectors in plant genetic engineering and non-harmful effects on host plants. But far from being friends, these viruses have now emerged as foes and are a serious threat to world agriculture now. Increase in international commodity trade, intercontinental transportation networks and a changing global climate have contribute to the spread of this virus and its whitefly vector (Moffat et.al.,1999).

RECENT ADVANCEMENTS: MICROSPONGE DRUG DELIVERY SYSTEM; A REVIEW

About Authors:
Deepak Sharma*, Arunabha Banik, S k Gupta
Department of Pharmaceutical Technology,
MIET,Meerut
*thakraan.southcarolina@gmail.com

ABSTRACT
The Microspongesdelivery system are extremely small, inert,indestructibleclusters of even tinierspherical particles of microscopic sizepatented polymeric delivery systems consisting of porous microspheres that can entrap a wide range of active ingredients such as emollients, fragrances, essential oils, sunscreens, and anti-infective, anti-fungal, and anti-inflammatory agents and are very well tolerated, and highly efficacious, novel productsthat do not pass through the skin, capable of holding four times their weight in skin secretionsand can absorb skin secretions. Like a true sponge, each microspheres consists of a myriad of interconnecting voids within a non-collapsible structure with a large porous surface. The size of the microsponges can be varied usually from 5-300µm in diameter, depending upon the degree of smoothness or after-feel required for the end formula. Although the microsponge size may vary, a typical 25µm sphere can have up to 250000 pores and an internal pore structure equivalent to 10ft in length providing a total pore volume of about 1ml/g. This results in a large reservoir within each microsponge, which can be loaded with up to its own weight in active agent. The microsponge particles themselves are too large to be absorbed into the skin and this adds a measure of safety to these microsponge materials. Another safety concern is the potential bacterial contamination of the materials entrapped in the microsponge. Because the size of the pore diameter is smaller than bacteria, ranging from 0.007 to 0.2µm, bacteria cannot penetrate into the tunnel structure of the microsponges.The microsponge system can prevent excessive accumulation of ingredients within the epidermis and the dermis. Potentially, the microsponge system can reduce significantly the irritation of effective drugs without reducing their efficacy.

Faculty Posts as Professors/Lecturers in Mangalayatan University - 7 posts

Mangalayatan University (MU) has been created under the "Mangalayatan University, Uttar Pradesh Act" and notified by the Government of Uttar Pradesh as Act No. 32 of 2006, by its Gazette No. 362/VII-V-1-1(Ka)-12/2006 dated October 30, 2006, with the right to confer degrees under section (2f) and 22(1) of the UGC Act.

Nanotechnology, an emergent field in drug delivery with potential to alleviate life threatening disease – A REVIEW

About Authors:
Aadeshkumar*, Nishantkumar gupta, Dineshkumar gupta
Dept. of pharmacy
BIT meerut, UP
*adesh.adi.chaudhary@gmail.com

ABSTRACT
In recent years there has been a rapid increase in nanotechnology in the fields of medicine and more specifically in targeted drug delivery. The proprietary powder processing techniques use by nanotherapeutics improves the delivery of drug that can not normally taken orally.
It improves
·         Safety and efficacy of low molecular weight drugs,
·         Stability and absorption of proteins that normally cannot be taken orally,
·         Extend the life cycle of existing drug formulation.

At present many substances are under investigation for drug delivery and more specifically for cancer therapy, AIDS and potential to cross the Blood Brain Barrier (BBB) has open new ways for drug delivery into the brain. Pharmaceutical sciences are also using nanoparticles to reduce toxicity and side effects of drugs. Nanoparticles are also have the potential as novel intravascular or cellular probes for both diagnostic and therapeutic purposes (drug/gene delivery) and nanosize allow access into cell and cell compartment including nucleus. . Discovery of nanomedicine has given rise to nanoparticles through which better target specific drug and gene delivery is possible. In conclusion nanoparticles for drug delivery and imaging have gradually been developed as new modalities for cancer therapy and diagnosis. This review illustrates the emerging role of nanotechnology in drug delivery.

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