About Authors:
Arvind Negi1*, Balraj Singh Gill2
1Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda- 151001
2Centre for Biosciences, Central University of Punjab, Bathinda-151001

Stereochemistry of clinical agents play a key role in their success to become drugs. Tautomerism is a structural isomerism, playing a key role in the orientation of organic compounds and also found significant in distinctive base pairing in nucleic acids. Keto-enol form usually occurs and found prominently among different types of tautomers. The enol form ionizes in the physiological solution into enolate and alter the biological activity. So, how this enolate form brings modification in pharmacokinetics and pharmacodynamics of a drug is very important and quite interesting to know. As this form is ionic in nature so it increases the interaction with the concerning receptors, enzymes, ion channels or functional proteins. In this review we cover and compile success, role and the significance of the enolate form of clinical agents which succeed to become drugs!



About Author:
Arvind Negi
Centre for Chemical and Pharmaceutical Sciences
Central University of Punjab, Bathinda-151001

Activation of immune response is developed in respect to some xenobiotic sensitization, which is supposed to prevent and protect the body from sufferings induced by these xenobiotic. But unfortunately sometime body behaves in a paradoxical manner which misguides the immune system and ultimately turned into a bizarre situation of immune function. One of such response is anaphylactic shock, which is quite fatal if untreated. This review brings insights into the molecular physiology of anaphylactic shock and how some people elicit allergic response to certain substances but not the other. This major catastrophe of the body holds an error of immune system whereas this commentary based review disclosed the synchronization of the unfortunate lessons of the immune system, which makes it a cruel to cause DEATH!

Walk in interview for Post graduate degree as Senior Research Fellow @ NIPER

The National Institute of Pharmaceutical Education and Research (NIPER) has been created as a centre of excellence for higher education, research and development in pharmaceutical sciences. NIPER, Rae Bareli at ITI campus, Rae Bareli under the mentoring Institute of Central Drug Research Institute, Lucknow invites eligible candidates for following positions on purely temporary basis on contract initially for a period of 1 year which can be extended further. The selected candidates shall have no claim for regularization against any regular post either in NIPER or CDRI.

Work as Assistant Professor - Pharmaceutical Management in Panjab University

The Panjab University has a long tradition of pursuing excellence in teaching and research in science and technology, humanities, social sciences, performing arts and sports. The University supports excellence and innovation in academic programmes, promotes excellence in research, scholarship and teaching and is committed to attracting and supporting the best students and faculty who excel at teaching and research. For more than a century, it has served various societal needs with distinction.

Walk in for various CSIR & DBT funded projects at IMTECH - 20 posts

CSIR - Institute of Microbial Technology, Chandigarh desires to engage Research Associate/Senior Project Fellows/Project Fellows on purely temporary basis on contract under CSIR Network projects/ DBT projects  at IMTECH. However, the number of positions may vary depending upon the requirement of the Institute. The Institute  also wishes to draw a Panel of Research Interns under “CSIR Diamond  Jubilee Research Interns Award Scheme”  to attract young and brilliant candidates to demonstrate their interest in Scientific Research as well as for qualifying and securing other research fellowships.  Panel  will be operative for a maximum period of one year from the date of interview.

Career for M.Sc / M.Pharm as Project Assistant @ Thapar University

Thapar University (TU) was established on 8 October 1956 as an Engineering College named Thapar Institute of Engineering and Technology. It is a University established in 1985 vide Sec.3 of the UGC Act, 1956 under notification # F.9-12/84-U.3. Thapar University offers Post-graduate and undergraduate programs in Engineering, Science, Management and Social Sciences.

Applications are invited for One post of Junior Research Fellow in the DST-SERB project in PGIMER

The PGIMER owes its inception to the vision of late Sardar Partap Singh Kairon, the then Chief Minister of Punjab and the distinguished medical educationists of the then combined state of Punjab, supported by the first Prime Minister of India Pt. Jawahar Lal Nehru who considered the institutions of scientific knowledge as temples of learning and the places of pilgrimage. The institute started in 1962 and Pt Jawahar Lal Nehru inaugurated the hospital now named “Nehru Hospital” on 7th July 1963. The Institute was originally under the Government of undivided Punjab. After the reorganization of the state, the administrative control of the institute passed on to the Union Territory of Chandigarh in November 1966.  The Institute became an autonomous body under the Act of Parliament in 1967 functioning under the Ministry of Health and Family Welfare, Government of India.

Applications are invited for One post of Junior Research Fellow in the DST-SERB project entitled “Treatment response evaluation in Locally Advanced Breast Cancer patients by FLTPET- CT after Neoadjuvant chemotherapy and correlation with tumour proliferation and apoptosis marker expression” under Dr. B.R. Mittal, in the department of Nuclear Medicine, PGIMER, Chandigarh.

Post: Junior Research Fellow (JRF)