Punjab

COATING TECHNOLOGY AND ITS RECENT ADVANCES – A REVIEW

ABOUT AUTHORS:
Vandna Dhiman*, Swati Modgil, Meenu Nagpal, Uprendra K Jain
Deptt. of Pharmaceutics, Chandigarh college of pharmacy,
Landran, Mohali-160065
*dhimanvandna27@gmail.com

ABSTRACT
Tablet coating is one of the oldest pharmaceutical process still in existence. It is a process of applying a thin polymer based film to a tablet or granule containing the active pharmaceutical ingredient. Solid dosage forms are coated for a number of reason, e.g. to control the drug release profile, to mask the bitter taste of the drug. There are various techniques for tablet coating such as sugar coating, film coating and enteric coating. Earlier, sugar coating was adopted for pharmaceutical as from the confectionary industry. But it was a tedious process and required skilled manipulation, therefore film coating was started to prefer over sugar coating. Film coating was mainly based on the solution of different polymers in organic and aqueous solution.

Career for B.Pharma or Graduate in Science as Nodal Officer in BPPI - 4 posts

This Jan Aushadhi Campaign has already started with the opening of the first Jan aushadhi store at Amritsar on 25th November 2008 with the active participation of the CPSUs namely, IDPL,HAL,BPCL,KAPL & RDPL. With the launch of the Jan Aushadhi store at Shastri Bhavan, New Delhi, on 5th February, 2009, the campaign is reaching an ambitious phase of launching of more than 45 stores in the States of Andhra Pradesh, Delhi, Rajasthan, Maharashtra, Haryana, Bihar, UP, Assam and Chattisgarh by March 2009.

DEVELOPMENT AND METHOD VALIDATION OF BACLOFEN BY RP-HPLC IN BULK DRUG AND PHARMACEUTICAL FORMULATION

ABOUT AUTHORS:
*Kamaldeep singh, Gurvinder Pal Singh, Sandeep Kumar Sharma
Adesh Polytechnic College,
Sri Muktsar Sahib 152026 (Punjab)
*kamalmehta86@yahoo.com

ABSTRACT
In the present work simple and sensitive RP-HPLC method has been developed for the quantitative estimation of Baclofen in bulk drug and pharmaceutical formulations.
A rapid and sensitive RP-HPLC Method with UV detection (253 nm) for routine analysis of Baclofen in Bulk drug and Pharmaceutical formulation was developed. Chromatography was performed with mobile phase containing a mixture of Methanol: Water: Acetic Acid (100:100:0.5) withflow rate 1.0 ml/min The linearity was found to be in the range of 10-50 µg/ml with (r2=0.999) A known amount of the drug solution (80, 100 and 120 %) was added to the powder sample of the tablet formulation and subjected to the estimation of the drug for the recovery studies. There was a high recovery of Baclofen (100.03%, 100.18%, and 100.05%) Robustness of the proposed method was determined by analysis of sample by changes in different parameter like flow rate, detection and Column temperature using similar operational and environmental conditions, the tailing factor was found to be less than 2. The precision of the assay was determined in terms of intra and inter-day variation in the peak area for a set of drug solution (30 µg/ml) assayed three times on the same day and on three different days  The intra and inter day variation in  the  peak  ratio of the drug  solution  was calculated in terms of co-efficient of variation (CV) and obtained by multiplying the ratio of standard deviation to the mean with 100(CV=SD/MEAN X 100)All the parameters are compared with standard raw material of baclofen. The proposed method was validated in accordance with ICH parameters and applied for analysis of the same in marketed formulations.The proposed method was validated by determining sensitivity, accuracy, precision, robustness stability

A REVIEW ON THERAPEUTIC POTENTIALS OF BERGENIA LIGULATA WALL

ABOUT AUTHORS:
Poonam Verma*, Bhuwan Chandra Joshi, Nitisha Negi
ISF College of Pharmacy,
Moga, Punjab
bhuwan.joshi000@gmail.com

ABSTRACT:
Bergenia ligulata
Wall also known as Pashanbhedain Indian system of medicine. Etymologically, the name Pashanbheda means that which breaks or destroys stones. Bergenia ligulata Wall is perennial herb that grows wild in stones and rocks. This plant has been recognized for dissolving kidney stone along with various biological activities, proving its several traditional uses. Bergenia ligulata Wall is a herb mainly found in Himalayan valley. Since it imparts different properties i.e. diuretic, anti diabetic, astringent, cardio tonic, wound healer, expectorant, antipyretic, hepatoprotective, anti cancer, antiprotozoal,  anti-inflammatory, kidney stone due to certain phytochemical constituents Bergenin, Tannic acid, Gallic acid, Stigmesterol, β-Sitosterol, catechin, (+)-Afzelechin, 1, 8-cineole, Isovalaric acid, (+)-(6S)-parasorbic acid, Arbutin, Phytol, Caryophyllene, Damascenone, β-eudesmol, 3-methyl-2-buten-1-ol, (Z)-asarone, Terpinen-4-ol, Paashaanolactone present in it. The aim of present article is to explore the medicinal importance of the plant Bergenia ligulata wall.


Pages