Guntur

About Authors:
YASWANTH ALLAMNENI^1*, NAVYA ALLAMNENI², P DAYANANDA CHARY¹, G VIJAY KUMAR³, ARUN KUMAR KALEKAR¹, PAVAN KUMAR POTTURI^1
1Research and Development Department, Natco Pharma Limited, Kothur, Mahaboobnagar,Andhra Pradesh – 509228.
²Department of Pharmaceutical Technology, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Guntur, India.
³Principal, A.K.R.G college of Pharmacy, Nallagerla, West Godavari, Andhra Pradesh.
*yaswanthallamneni@gmail.com

ABSTRACT
Water is widely used as a raw material, ingredient, and solvent in the processing, formulation, and manufacture of pharmaceutical products, active pharmaceutical ingredients (APIs) and intermediates, compendial articles, and analytical reagents. This review discusses, primarily from a microbiological aspect, the review and evaluation of high purity water systems that are used for the manufacture of drug products and drug substances. It also includes a review of the design of the various types of systems and some of the problems that have been associated with these systems. As with other guides, it is not all-inclusive, but provides background and guidance for the review and evaluation of high purity water systems. The main objective of this review was to provide guidance to the industry on the pharmaceutical use of different grades of water in the manufacture of active pharmaceutical ingredients and medicinal products for human and veterinary use. This guidance is not intended to cover situations where, for example, medicinal products are prepared extemporaneously or where preparations are reconstituted or diluted with water prior to use by pharmacist (eg. Oral antibiotic mixtures) or in the case of veterinary products by the user (eg. Sheep dips).

About Authors:
M.sandhya sree*, Sowmya**
*Assistant Professor ,
Department of pharmacology,
BA&KR pharmacy college,
JNTUK, Andhra Pradesh.
**MBBS,GMC,
Guntur, Andhra Pradesh.

Abstract:
The study was conducted in two villages of Guntur district (Andra Pradesh) to determine the nature and extent of health problems of rural women. The data were collected from one hundred randomly selected rural ladies by interviewing them with the help of an interview schedule developed for  the  purpose.
The identified health problems were classified. The findings of the study indicated the prevalence of a number of health problems among rural women and a need was felt for their education on health aspects. A sizeable number of them were found to have suffered from bronchitis, coryza, indigestion, constipation, diarrhea , conjunctivitis, dandruff, tartar deposits on teeth, skin diseases, gynecological diseases and some other diseases like rheumatism, arthritis, etc.
The existence of a government hospital in village had no association of significant level with the health problems of rural women. Majority of the respondents perceived the treatment given in government hospital to be not effective and several other constraints in availing of the treatment facilities.

About Authors:
Sahithya Bitragunta, Ponnuru Venkata Suresh, Nadendla RamaRao
Chalapathi institute of pharmaceutical sciences,
Lam,Guntur,
India.

Abstract:
In 1960’s, different countries used to have different set of guidelines and laws for the registration and marketing of pharmaceuticals. But tragedies like Thalidomide disaster made harmonization of all technical requirements which are required for the registration of pharmaceuticals for the human use. Thus ICH has been launched in 1990 by drug regulatory authorities and pharmaceutical industrial members of Europe, Japan and US with an objective of providing guidelines to ensure the registration and marketing of safe, effective and high quality medicines.

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ABOUT AUTHORS:
Amar Nagesh Kumar¹, Reena jose², Praswetha Reddy³
1 Lecturer, Department of Biochemistry, SSR Medical College, Mauritius
2 M. Sc Biotechnology, Yogi Vemana University
3 M. Sc Biochemistry, Mahatma Gandhi P.G College, Guntur

OBJECTIVE:To estimate the given samples of DNA qualitatively and quantitatively and know its purity and concentration.

 BACKGROUND
Quantification of nucleic acids is commonly used in molecular Biology to determine the concentration of DNA and RNA present in the mixture As subsequent reaction or protocols using the nucleic acids sample of a required particular amount of optical performance. Both DNA and RNA exhibit strong absorbance of UV due to the presence of conjugated double bonds of the constant purine and pyramidine bases and these have characteristics of OD (optical density)of absorbance maximum at 260nm which is linearly related with the concentration  of the DNA in the solution up to the OD value of 2 . The spectroscopic method is used to check the purity of DNA. Proteins are the major contaminants in the nucleic acid extracts and these have the maximum absorbance at 280nm. Value less than 1.8 signifies the presence of proteins as impurities.

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Post: Pharmacits

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