Gujarat

The National Institute of Pharmaceutical Education & Research (NIPER) is an Institute of National importance established by an Act of Parliament under the aegis of Department of Pharmaceuticals,Ministry of Chemicals & Fertilizers, Government of India. The Institute has excellent facilities for advanced education and research in pharmaceutical sciences and is looking for teaching and non- teaching staff of high degree of knowledge and willing to contribute in building this institute as one of the best centres of excellence. Presently the Institute is running M.S (Pharm.) and Ph.D Programmes and planning to expand further.

NIPER-Ahmedabad invites applications from highly qualified young scientists holding Ph.D. in the areas of Pharmaceutical,Biological and Chemical Sciences/Engineering/Technology for the Institute Postdoctoral Fellowships commencing on 30th June, 2017.

Ishita Drugs & Industries Limited is the flagship company of the ‘Ishita’ Group, which is a respected member of the Indian Business community for more than 3 decades. The Group’s interests encompass manufacturing of a large number of Bulk Actives and their salts, Drug Intermediates etc.

Post : Quality Control Executive - 02 posts

Alembic Pharmaceuticals Limited, with an established presence in the Indian pharma industry has a proud, historical track record going back over 100 years.

To realize our ambitious plans, we call upon dynamic, result oriented team members to join our API & Formulation manufacturing unit located at PANELAV, near Vadodara (Gujarat).

Post: Executive/Sr. Executive/Asst. Manager/ Dy. Manager/Manager

Boehringer Ingelheim is an equal opportunity employer who takes pride in maintaining a diverse and inclusive culture. We embrace all aspects of diversity and inclusion which benefit our employees, patients and communities. Minority/Female/Protected Veteran/Person with a Disability (Applicable in United States of America).

Post : Area Sales Manager - Mehsana (Diabetes)-176365

Vitalysis is one of the fastest growing Export marketing & Strategic Business Consultancy Company with comprehensive HRM solutions provider.   VITALYSIS is a professionally Managed young & dynamic organization With a Pure focus on Pharmaceutical & Healthcare Industry Practices.

Post : Business Development Manager

Vitalysis is one of the fastest growing Export marketing & Strategic Business Consultancy Company with comprehensive HRM solutions provider.   VITALYSIS is a professionally Managed young & dynamic organization With a Pure focus on Pharmaceutical & Healthcare Industry Practices.

Post : Training Manager

Otsuka Pharmaceutical India Private Limited (OPI) is a major player in Infusion Business in India and Emerging Markets. We primarily manufacture & market products across multiple markets and therapeutic segments. To keep pace with our growth plans, we require experienced and highly competent team members in following areas for our manufacturing facility at Ahmedabad, Gujarat.

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ABOUT AUTHOR
Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry,
Shri Sarvajanik Pharmacy College,
Mehsana, Gujarat, India
dhrubosen69@yahoo.com

ABSTRACT: Our goal is to perform in-vitro biotransformation of Prodrugs of ibuprofen+paracetamol, diclofenac sodium+paracetamol and ibuprofen+diclofenac sodium by acidic and alkaline hydrolysis of both ester (–COO–) and amide (–CONH–) linkages into free drugs and chromatographically separation of their Rt in HPLC. Since both ester (–COO–) and amide (–CONH–) linkages are susceptible for hydrolysis in both acidic pH (gastric pH) and basic pH (intestinal pH) to produce parent drug ibuprofen, diclofenac and paracetamol by biotransformation in in-vivo; so it will be implemented as a Prodrug which can show prolong action on pain and fever after getting release into free parent drug by biotransformation. The HPLC (High Performance Liquid Chromatography) study reports the retention time (Rt) and release kinetics of three Prodrugs by taking HPLC degradation datas of three samples of Prodrugs and individual HPLC datas of parent drugs separately to compare the Rt value of release of three drugs from Prodrugs in both acidic and alkaline pH. Prodrug–A (logP=4.56) releases Ibuprofen & Paracetamol, Prodrug–B (logP=4.90) releases Diclofenac & Paracetamol and Prodrug–C (logP=6.13) releases Ibuprofen & Diclofenac. This is a comparison study of drug release in in-vitro gastric as well as intestinal pH focusing on in-vivo biotransformation.  Keywords: Prodrug-A/Prodrug-B/Prodrug-C, Ibuprofen, Paracetamol, Diclofenac sodium, Molecular weight, logP, UV λmax, IR, Mobile phase, TLC-Rf value, HPLC-Rt value, LOD, LOC