Study of in-vitro biotransformation of prodrugs of Ester and Amide linkages of Ibuprofen, Diclofenac Sodium and Paracetamol in acidic and alkaline medium

  • Posted on: 31 July 2017
  • By: admin

 

Magazine Home


August 2017 ARTICLE LIST >>

PharmaTutor (July - 2017)

 

ISSN: 2347 - 7881
(Volume 5, Issue 8)

 

Received On: 23/05/2017; Accepted On: 23/05/2017; Published On: 01/08/2017

 

AUTHORS:
Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry,
Shri Sarvajanik Pharmacy College,
Mehsana, Gujarat, India
dhrubosen69@yahoo.com

 

 

ABSTRACT:
Our goal is to perform in-vitro biotransformation of Prodrugs of ibuprofen+paracetamol, diclofenac sodium+paracetamol and ibuprofen+diclofenac sodium by acidic and alkaline hydrolysis of both ester (–COO–) and amide (–CONH–) linkages into free drugs and chromatographically separation of their Rt in HPLC. Since both ester (–COO–) and amide (–CONH–) linkages are susceptible to hydrolysis in both acidic pH (gastric pH) and basic pH (intestinal pH) to produce parent drug ibuprofen, diclofenac and paracetamol by biotransformation in in-vivo; so it will be implemented as a Prodrug which can show prolong action on pain and fever after getting released into free parent drug by biotransformation.

 

 

How to cite this article: Sen DJ;Study of in-vitro biotransformation of prodrugs of Ester and Amide linkages of Ibuprofen, Diclofenac Sodium and Paracetamol in acidic and alkaline medium; PharmaTutor; 2017; 5(8); 49-65

 

[ABSTRACT WITH CITATION]   [VIEW AS HTML