Gujarat

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ABOUT AUHTOR
HardikRana*, BhargavVaghasiya, MansiDholakia
Department of Pharmaceutics,
Anand Pharmacy College, Anand, 388 001, Gujarat, India.
*hardikrana1439@gmail.com

ABSTRACT
The objective of present study was to enhance the solubility of poorly soluble drug Ibuprofen using spherical crystallization technique.The potential agglomerates were prepared by addition of different concentrationof polymer selected on the basis of Phase solubility study. Spherical agglomerates were prepared using diethyl ether as bridging liquid by neutralizing technique, spherical agglomeration technique, Quasi emulsion solvent diffusion technique. Spherical agglomerates were evaluated for morphology, production yield, drug content, particle size and dissolution behaviour compared with pure drug.The result of phase solubility studies revealed that there is enhancement of solubility by PEG 4000. Rod shaped crystals of pure drug converted to spherical was confirmed by optical microscopy. The dissolution of agglomerates of optimum batch exhibited 88.24% release compare to 47.18% of pure drug within 60 minute. This study demonstrated that spherical crystallization technique can be consider as a suitable alteration of granulation. Ibuprofen spherical agglomerates can be prepared with PEG 4000. It exhibited excellent physicochemical, solubility, dissolution rate in comparison with pure drug. Among other spherical crystallization technique, QESD proved to be excellent techniquefor enhancement of solubility and dissolution.

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ABOUT AUHTOR
Manish Patil*¹, Harsha D Jani¹, Suleman S Khoja², Narmin A Pirani³, Shamim S Khoja^3
1Department of Quality Assurance,
Shivam Pharmaceutical Studies and Research Centre, Anand
Gujarat, India.
²Resource person in pharmaceutical quality assurance and Audit Compliance, Vapi
³Registered Pharmacist, Gujarat, India
*manishpatil3194@gmail.com

ABSTRACT
This review article presents the pharmacology of combined Metformin hydrochloride and Teneligliptin hydrobromide hydrate is effective on type 2 Diabetes Mellitus. Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Teneligliptin, a third generation Dipeptidyl Peptidase-4 (DPP-4) inhibitor exhibits unique “J shaped” structure with “anchor-lock domain” mechanism which provides potent & long duration of action. The addition of teneligliptin once daily to Metformin was effective and generally well tolerated in Korean patients with type 2 diabetes. The mechanism of Metformin hydrochloride and teneligliptin hydrobromide hydrate is quite different. The main objective of this review article is to provide pharmacological and Analytical information of combination of Metformin hydrochloride and Teneligliptin hydrobromide hydrate to researcher in development of combined dosage form.

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Gujarat Ayurved University was established in 1967 by an act passed by Gujarat State legislative Assembly in 1965. It is the first statutory University of its Kind both at national and international level - exclusively devoted to Ayurvedic studies and Research. This University is administratively linked to Ministry of Health and Family Welfare both at State and Centre-indicating its special status.

Post: Teaching Assistant

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Tweet India Pharmaceuticals Pvt. Ltd. is being headed by Mr. A. K. Arora, who is backed up by his more than 35 years practical and successful experiences of Pharmaceutical Industry and has given his precious and valuable guidance in formulating latest strategies which is followed by many Pharmaceutical Companies, and has been the milestone for the Pharmaceutical Industries.
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NIPER Ahmedabad is organizing one day seminar on theme entitled “What do the fresher’s lacks for getting better jobs; A human resource perspective for Pharma industry and academia” on 3rd of December 2016.