Rajasthan

About Authors:
Kalpesh N. Patel¹*, Jayvadan K. Patel^2
1 Research Scholar, Jodhpur National University, Jodhpur,
Rajshathan, India
² Department of Pharmaceutical Technology,
Nootan Pharmacy College,
Visnagar (GUJARAT), India.

Abstract
Two simple spectrophotometric methods have been developed for simultaneous estimation of pyrimethamine and sulphadoxine from tablet dosage form. Method-I simultaneous equation method involves the measurement of absorbances at two wavelengths 215 nm (λmax of pyrimethamine) and 254 nm (λmax of sulphadoxine) in methanol and Method-II first order derivative spectroscopic method involves the measurement of absorbances at two wavelengths 250 nm (λmax of pyrimethamine) and 220.5 nm (λmax of sulphadoxine); The linearity lies between 5-30 µg/ml for both pyrimethamine and sulphadoxine for all the two methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 2. All method were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of pyrimethamine and sulphadoxine in bulk and combined dosage form.

The Ministry of Health & Family Welfare, Government of India is setting up these six Autonomous Institutions of National Importance. For Faculty Positions/ Senior Residency applications are invited from Indian Nationals and Persons of Indian Origin holding OCI Status. Regular, Deputation, contractual appointments are open.

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About Authors:
Rakesh Bhatia
School of Pharmaceutical Sciences, Department of Chemistry,
Jaipur National University, Jaipur-302025,
Rajasthan, India

ABSTRACT
QSAR has been applied extensively and successfully over several decades to find predictive models for activity of bioactive agents. QSAR have brought revolution in drug discovery process by thedevelopment of mathematicalrelationships linking chemical structures and pharmacological activity in quantitative manner of series of compound. The mathematical relationships between molecular descriptors and activity are used to find the parameters affecting the biological activity and/or estimate the property of other molecules. Description of the molecular structure, electronic orbital reactivity and the role of structural and steric components have been the subject of mathematical and statistical analysis. This review seeks to provide an evolution of QSAR and development of receptor theory.

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About Authors:
Middha Akanksha*, Kataria Sahil, Sandhu Premjeet, Arora Praveen
Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan,
INDIA
*Akankshamddh@gmail.com

Abstract
Nuclear Magnetic Resonance (NMR) Spectroscopy is not limited to the study of protons. Any element with a nuclear spin (¹³C, ¹⁷O, ¹⁹F, ³¹P and many others) will give rise to an NMR signal.Carbon-13 NMR (¹³C NMR or referred to as carbon NMR) is the application of nuclear magnetic resonance (NMR) spectroscopy applicable to carbon. It is similar to proton NMR (1 H NMR) and allows the identification of carbon atoms whereas in other identification of H. As such ¹³C NMR is an important tool in chemical structure elucidation in organic chemistry. ¹³C NMR detects only the 13C isotope of carbon, whose natural abundance is only 1.1%, because  the main carbon isotope, 12 C, is not detectable by NMR since it has zero net spin.

About Authors:
Nishant Gupta
Department of pharmaceutics,
B.N. College of pharmacy,
Udaipur-313002,
Rajasthan

ABSTRACT:
Paroxetine (PRX) crystals exhibit poor compressibility, poor flowability and its tablets show a tendency to cap. To improve the mechanical strength of tablets several kinds of “Paroxetine for direct compression” are present on the market. Current research demonstrated the best tablet properties with coated paroxetine (mass of tablets, diameter, height and mechanical strength, friability RSD<2%). Furthermore, coated paroxetine in combination with both investigated superdisintegrants such as Vivasol® and Polyplasdone® XL-10 shows faster disintegration time and dissolution rate in comparison to paroxetine for direct compression. Eventually, the major advantages of the formulation with coated paroxetine for industrial production are decrease of friability and superiority in terms of flowability, compressibility, quick disintegration and dissolution. Regarding the results, coating of PRX particles is beneficial for the manufacturing of tablets with immediate release.

About Authors:
Honey Jain, Neha Batra
School of Pharmaceutical Sciences,
Jaipur National University,
Jaipur

ABSTRACT
The family Cyperacea includes approximately 3000 species of which about 220 species are identified as weeds and of which 42% of these weeds are in the genus Cyperus. Both purple nutsedge (Cyperus rotundus L.) and yellow nutsedge (C. esculentus L.) are problem weeds in many parts of the world. Nutsedges originate from tropical and subtropical areas. . The plant produces rhizomes, tubers, basal bulbs and fibrous roots below ground, and rosettes of leaves, scapes, and umbels above ground.  C. rotutdus consists of rhizome and stolon having a number of wiry roots, stolon 10-20 cm long having a number of rhizomes, crowded together on the stolons, rhizomes bluntly conical and vary in size and thickness.The rhizomes are initially white and fleshy with scaly leaves and then become fibrous, wiry, and very dark brown with age. Purple nutsedge is readily distinguished from yellow nut sedge and other sedges by its purplish brown spikelets and scaly or wiry rhizomes that often bear chains of tubers.Phytochemical studies have shown that the major chemical components of this herb are polyphenol, flavonol glycoside, alkaloid, saponins, sesquiterpenoids and essential oil. Rhizome of the plant is used in fever,arthritis,diuretic, nervine tonic, treatment of diarrhea and dysentery ,leprosy, bronchitis, amenorrhea, and blood disorders. Leaves and seeds are rich in volatile oil and act on digestive system. Fruits are used as carminative , diuretic tonic, stomachic. Oil is fungicidal and bactericidal.

About Authors:
PANKAJ MUSYUNI*, PROF. (Dr.) B.P. NAGORI¹, Mr. AKASH MIDHA²
*M. Pharm. (Pharma Management & Regulatory Affairs)
1 Director, Lachoo Memorial College of Science & Technology
2. Lecturer, Lachoo Memorial College of Science & Technology
Lachoo Memorial College of Science & Technology
‘Pharmacy Wing’, Jodhpur, Rajasthan
INDIA

ABSTRACT
Ethics can be explained as branch of philosophy related with the implication of all aspects of human behavior and nature. The purpose of this paper is to present an overview and relevance of business ethics in management and pharmaceutical industry scenario. The rationale of business can not be only illustrated by profit maximization but also by the social concern of the organization. This paper demonstrates the concept of business ethics with various attributes, factors and impact on society and also emphasize on code of ethics and its importance. Present paper also discusses common ethical problems within a pharmaceutical organization. A practical approach as case studies related to pharmaceutical industries will identify the issues and implications for ethical development, advancement and globalization of business ethics. Concept of paper focuses attention on the development of an attitude which should be adopted to understand various terms of ethics and development for social and business concern.

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