TOPOISOMERASE
About Authors:
B. A. Baviskar1, S. S. Khadabadi2, S. L. Deore1*, R. P.Marathe1
1Government College of Pharmacy, Kathora Naka,
Amravati – 444604, MS, INDIA.
2Government College of Pharmacy, Aurangabad Opp. Govt. Polytechnic, Osmanpura, Aurangabad-431005,
Maharashtra INDIA
*sharudeore_2@yahoo.com
Abstract: Topoisomerase is an enzyme that alters/regulates the super coiling of double-stranded DNA by transiently cutting one or both strands of the DNA and hence important target for anticancer activity. The present review articles is focusing a light on points like What is topoisomerase, its types, mode of action of cancer inhibition, Top-I targeted anticancer drugs, Top-II targeted anticancer drugs and Topoisomerase Cellular resistance.