Amravati

ABOUT AUTHOR:
Abhijeet Welankiwar.
Govt. College of pharmacy
kathora naka Amravati (Maharashtra) 444604.
abhi123welankiwar@gmail.com

ABSTRACT:
The oral route of drug delivery is typically considered the preferred and most patient-convenient means of drug administration. With many drugs the basic Goal of therapy is to achieve a steady-state blood or tissue level that is therapeutically effective and nontoxic for an extended period of time. Sustain release system are considered a wiser approach for the drugs with short half-lives and which require repeated dosing, they are easy to formulate and are irrespective of absorption process from gastrointestinal tract after oral administration. The basic objective of these dosage forms is to optimize the delivery of medications so as to achieve a measure of control on therapeutic effect in the face of uncertain fluctuations in the in vivo environment in which drug release takes place. The advances in the formulation technology of modified release dosage form with sustained release oral dosage form has been widely accepted approach as compared to conventional immediate release formulations of the same drug, over which it provides a prolong release of the drug over extended period of time there by giving the better patient compliance and enhanced bioavailability and resulting blood concentration-time profiles of drugs that otherwise suffer from few limitations.

State Health Society invites applications for filling vacant positions in district level

Post: Pharmacists

About Authors:
Mohd Farhan
Department of Pharmacology,
Vidyabharti college of pharmacy
Amravati.
farhan.pharma66@gmail.com

Abstract:
The herbal medicine are in the great demand in the developed as well as developing countries for primary health care because of their large biological activities, higher safety margin and lesser cost. one of the common traditional herbal drug is Emblica officinalis, commonly known as Amla, is a member of a small genus Emblica (Euphorbiaceae). It grows in tropical and subtropical parts of China, India, Indonesia and the Malay Peninsula. All parts of the plant are used for medicinal purpose. The fresh (or) the dry fruit is used in traditional medicines for the treatment of diarrhoea, jaundice and inflammations. The pulp of the fruit is smeared on the head to dispel headache and dizziness Emblica officinalis leaves and fruit have been used for fever and inflammatory treatments by rural populations in its growing areas. The earlier study have demonstrated potent anti-microbial, adaptogenic, hepatoprotective, anti-tumour and anti-ulcerogenic activities in the fruits of Emblica officinalis. Leaf extracts have been shown to posses anti- inflammatory activity. vitamin C, tannins and flavanoids present in amla have very powerfull antioxidant activity. Due to rich in vitamin C amla is successfully use in the treatment of human scurvy.

About Authors:
H.S.Sawwalakhe*, J.M.Maidankar, M.A.Channawar, Dr.A.V. Chandewar
P. W. College of Pharmacy, Yavatmal,
Amravati university
*hemant_11sep@rediffmail.com

ABSTRACT:
The demand for mouth dissolving tablets has been growing during the last decade especially for elderly and children who have swallowing difficulties. Chlorpheniramine maleate is a non-steroidal anti-inflammatory drug (NSAID) histamine H1 antagonist with antihistamine drug it is commonly used  in allergic reactions, hay fever, rhinitis, urticaria, and asthma. The main criteria for mouth dissolving tablets are to disintegrate or dissolve rapidly in oral cavity with saliva in 15sec to 60sec with need of water. The disintegrants used should fulfill the criteria by disintegrating the tablets in specified time limit.in the present investigation variety of super disintegrants Crospovidone, sodium starch glycolate,kyron t-314 , were selected and tablets were prepared by direct compression method in different concentration like 3%,6% and 8%. The prepared tablets were evaluated for weight variation, hardness, friability, in vitro disintegration time, wetting time, in vitro dissolution study, etc.formulation f-9 shows the lowest disintegration time (29sec) and wetting time (37sec). In vitro dissolutionstudies revealed that formulation F-9 containning 9% t-314  showed 98% drug release at the end of 10 min.

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