• 22 March 2015

    2D QSAR STUDY ON SAPONINS OF PULSATILLA KOREANA AS AN ANTICANCER AGENT

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Sagar Alone*, Sharda Deore, Bhushan Bawiskar
    Department of Pharmacognosy & Phytochemistry
    Govt. College of pharmacy, Kathora naka, Amravati-444604, India
    *sagaralone123@gmail.com

    ABSTRACT
    Total seventeen saponins previously isolated from roots of Pulsatilla koreana having cytotoxic activity against 4 different cancer cell line (A-549, SK-OV-3, SK-MEL-2, HCT15) were used for 2D QSAR using V-life Molecular design suit. Using multiple linear regression method against 4 different cell lines develops QSAR model. QSAR model was generated by using training set of 11 and test set of 6 molecules having correlation coefficient (r2), significant cross validated correlation coefficient (q2) and F-test (For statistical significance) is as given below  (A-549: r2- 0.9281, q2- 0.8691, F-test- 51.6079),  (SK-OV-3: r2- 0.9554, q2- 0.9184, F-test- 85.7357),  (SK-MEL-2: r2- 0.9160, q2- 0.8285, F-test- 43.6084),  (HCT15: r2- 0.9203, q2- 0.8357, F-test- 46.1887). In this QSAR study Alignment independent descriptors such as T_2_C_7, T_O_O_5 and physicochemical descriptors like Chain path count such as 6 chain count and Chi chain such as Chi 6 chain were most responsible descriptors for anticancer activity.

  • 1 August 2013
    Opening for Area Sales Manager in Leading for Pharma Company | 5 Posts

    Leading for Pharma Company

    Post: Area Sales Manager - 5

    [adsense:336x280:8701650588]

  • 3 July 2013
    Admission opportunity in B.Pharm and M.Pharm at Lovely Professional University

    Pharmacy is a dynamic, growing, and increasingly diverse profession, one which creates an excitement because there are so many opportunities for service. The secret in the future will be to identify and take advantage of these opportunities.

  • 3 July 2013
    REVIEW: REGULATORY PROVISIONS REGARDING COSMETICS IN INDIA

    ABOUT AUTHOR:
    Abhijeet Welankiwar
    Govt. college of Pharmacy,
    kathora naka,
    Amravati (Maharashtra), 444604.
    abhi123welankiwar@gmail.com

    ABSTRACT:
    The Government of India through the Drug and Cosmetic act 1940 and rules 1945 has made stringent provisions regarding import, Manufacturing, Sale and Distribution of Cosmetics. These provisions mainly cover the licensing for the import, manufacturing of cosmetics and also the GMPs for the manufacturing of cosmetics. Also these guidelines have covered certain categories of cosmetics whose import and sale is prohibited by the Law. These guidelines have also listed the 28 cosmetics whose import is allowed only on to the conformance to the Indian standards. These guidelines have also covered the offences and penalties in case of contravention of the provisions of the Drug and Cosmetic Act 1940.

  • 30 June 2013
    Shoolini University offers admission for B.Pharmacy, M. Pharmacy (Pharmaceutics, Pharm. Chemistry, Pharmacology, Pharmacognosy, Quality assurance, Biotechnology), B. Pharm MBA (Integrated), and PhD programs

    Shoolini University is is located in a thick grove of pine trees, 14 km from Solan with cool summers and pleasant winters, and an ideal destination for academic and research romance. It has adopted research driven model and its strength emanates from Sound Governance and Cultural Heritage. Governing Body is comprised of distinguished academicians, entrepreneurs, professional executives and consultants.

  • 26 May 2013
    Opportunity to get Training for Medico-Medical Writing in Tulip Medcom

    Medical writing is part and parcel of drug development process. Medicomarketing communication or healthcare communication has evolved as a profession over a decade. More and more pharmaceutical industries are outsourcing their work to medicomarketing communication or healthcare communication companies/freelance medical writers.

  • 7 April 2013
    REVIEW: SUSTAINED RELEASE DOSAGE FORMS

    ABOUT AUTHOR:
    Abhijeet Welankiwar.
    Govt. College of pharmacy
    kathora naka Amravati (Maharashtra) 444604.
    abhi123welankiwar@gmail.com

    ABSTRACT:
    The oral route of drug delivery is typically considered the preferred and most patient-convenient means of drug administration. With many drugs the basic Goal of therapy is to achieve a steady-state blood or tissue level that is therapeutically effective and nontoxic for an extended period of time. Sustain release system are considered a wiser approach for the drugs with short half-lives and which require repeated dosing, they are easy to formulate and are irrespective of absorption process from gastrointestinal tract after oral administration. The basic objective of these dosage forms is to optimize the delivery of medications so as to achieve a measure of control on therapeutic effect in the face of uncertain fluctuations in the in vivo environment in which drug release takes place. The advances in the formulation technology of modified release dosage form with sustained release oral dosage form has been widely accepted approach as compared to conventional immediate release formulations of the same drug, over which it provides a prolong release of the drug over extended period of time there by giving the better patient compliance and enhanced bioavailability and resulting blood concentration-time profiles of drugs that otherwise suffer from few limitations.

  • 5 April 2013
    REVIEW: TABLET COATING PROCESS

    ABOUT AUTHOR
    Abhijeet Welankiwar
    Govt. College of pharmacy, kathora naka,
    Amravati (Maharashtra) 444604
    abhi123welankiwar@gmail.com

    ABSTRACT:
    Tablet coating is the key step involved in the manufacturing of tablets having controlled release, delayed release profiles. The tablet coating have number of advantages like masking odor, taste, color of the drug, providing physical and chemical protection to drug, Protecting drug from the gastric environment. 3 primary components of tablet coating are tablet properties, coating process and coating composition. Tablets are usually coated in horizontal rotating pan with coating solution is either directly poured or sprayed on to them. The amount of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form. Recent trends in tablet coating focuses on overcoming disadvantage of solvent based coating. This article concerns with the coating process, equipments involved, coated tablets evaluation and specialized coating techniques.

  • 8 March 2013
    REVIEW - QUALITY CONTROL OF PARENTERAL PRODUCTS

    About Authors:
    Abhijeet Welankiwar*, Sushant Tope
    Government college of pharmacy Amravati
    Kathora naka, amravati (maharashtra) 44460
    *abhi123welankiwar@gmail.com

    ABSTRACT:
    In a pharmaceutical organization a quality control is a fundamental segment that refers to a process of striving to produce a product by a series of measures requiring an organized effort by entire company to eliminate or prevent error at any stage of production. Quality control deals with testing, sampling, specification, documentation, release procedure which ensure that all tests are actually carried out prior to release of material for sale or use. Until its quality judged to satisfactory. This article deals with quality control of parenteral preparation which have 4 basic area that are Sterility, Freedom form Pyrogens, Freedom from particulate matter and leakers. It gives details on each of these 4 Basic areas. The achievement of sterile, non pyrogenic and particulate free parenteral product provides a significant challenge to ingenuity and creativity of parenteral scientist and technologist.

    [adsense:336x280:8701650588]

  • 25 February 2013
    Walk in Opportunity for Pharmacist in NRHM - Total 635 vacancies

    State Health Society invites applications for filling vacant positions in district level

    Post: Pharmacists

    [adsense:336x280:8701650588]

Subscribe to Amravati