Meerut

Vacancies for Associate Professor, Lab. Technician in Subharti University

Subharti is a tangible manifestation of the lofty ideals of a visionary, Dr. Atul Bhatnagar, a noted surgeon of Western UP, who had always nurtured a dream & desire to make a significant contribution to the nation through education. Thus was born the idea of establishing a university. The endeavour to make the University at par with any other University nationally & internationally has gained impetus & momentum under the presidentship of Dr.

DEVELOPMENT OF DOMPERIDONE NASAL GEL USING NATURAL MUCOADHESIVE AGENT OBTAINED FROM THE FRUITS OF DELLINIA INDICA. L.

About Authors:
Dharmendra Kumar*, BhanuPriya, S.K Gupta
*Department of Pharmaceutical Technology,
Meerut Institute of Engineering and Technology,
Meerut, Uttar Pradesh, India, 250005
*rvnimiet@gmail.com

Abstract.
The aim of this research work was replaced the tablet or injection of Domperidone by using domperidone nasal gel forrmulations. In research, day to day newer novel drug delivery comes for various drugs nasal gel drug delivery system one of them. Purpose of this study is formulating a nasal gel of Domperidone by using natural mucoadhesive agent extract from Dellinia Indica. In vitro drug release study carried out by using Franz-diffusion cell and excised bovine nasal membrane,characterisation was also found to be better in comparison to the HPMC and carbapolsynthetic polymers. Dellinia indica has valuable properties as a mucoadhesive agent because it is considered to be biocompatible, biodegradable and non-toxic. In future nasal gel formulations replace tablet/injection of Domperidone.


A REVIEW ON RECENT TRENDS IN ORAL DRUG DELIVERY- MOUTH DISSOLVING FORMULATION

ABOUT AUTHORS:
Manish Goswami, U.K.Singh, Rajat Kumar
Kharvel subharti college of pharmacy (swami Vivekanandsubharti University) Subhartipuram,
N.H-58, Meerut By Pass Road,
Meerut, uttarpradesh- 250001, India.
*manish.revosys88@gmail.com

ABSTRACT:
The desire of improved palatability in orally administered products has prompted thedevelopment of numerous formulations with improved performance and acceptability. Mouth dissolving tablets (MDTs) have received ever-increasing demand during the last fewdecades, and the field has become a rapidly growing area in the pharmaceutical industry. Theunique property of mouth dissolving tablet is that they are rapidly disintegrating and/ordissolving and release the drug as soon as they come in contact with saliva, thus obviate therequirement of water during administration. this review also provides the detailed concept of some unique patents; technologiesdeveloped and marketed formulations of Mouth Dissolving Tablets(MDTs).The present investigation was undertaken with a view to develop mouth-dissolving tablets which offer a new range of product having desired characteristics and intended benefits. Mouth dissolving tablets are advantageous particularly for pediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. The basic approach used in development of MDT is the use of super disintegrants like Crosslinked carboxymethyl cellulose (Croscarmellose), Sodium starch glycolate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. whichprovide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva.

DOMPERIDONE NASAL GEL USING NATURAL MUCOADHESIVE AGENT OBTAINED FROM TAMARIND SEEDS

About Authors:
Dharmendra Kumar*, Bhanu Priya, Sumedha Bansal,
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology,
Meerut, Uttar Pradesh, India, 250005

* rvnimiet@gmail.com

Abstract
A new Nasal drug delivery system of Domperidone has been developed as decent drug delivery by using natural mucoadhesive agent extract from Tamarindus indica L. The mucoadhesive strength, pH, viscosity and gelling property of this natural mucoadhesive agent was found to be higher in comparison to synthetic polymers, hydroxy propyl methyl cellulose (HPMC) and carbopol which are conventionally used for similar purpose. In vitro drug release characteristic through franz-diffusion cell using excised bovine nasal membrane was also found to be better in comparison to the above synthetic polymers. Now patient friendly, needle free dosage form may replace the Domperidone injections/ tablets in future.

DESIGN, DEVELOPMENT AND FUTURE APPLICATION OF MICROSPHERES

About Authors:
Divya Rawat, U.K.Singh, Faizi Muzaffar
Kharvel Subharti College of Pharmacy,
swami Vivekanand subharti university, Subhartipuram,
N.H-58, Meerut By Pass Road, Meerut, Uttar Pardesh-250001, India
*drawat05@gmail.com

Abstract
Microspheres constitute an important part of novel drug delivery system by virtue of their small size and efficient carrier capacity. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 μm. The range of Techniques for the preparation of microspheres offers a Variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs also known as micro particles. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs. The purpose of the review is to compile various types of microspheres, different methods to preparation, its applications and also various parameters to evaluate their efficiency.

ORAL DELIVERY OF INSULIN AND ITS CURRENT STATUS

About Authors:
Kritika Rastogi, U.K. Singh, A.K. Chaturvedi
Kharvel Subharti College of Pharmacy, (swami vivekanand subharti university) subhartipuram,
N.H-58, Meerut By Pass Road, Meerut, Uttar pradesh-250001,India.
*kritikarastogi6@gmail.com

Abstract
Insulin remains the most effective and durable hypoglycemic agent for the treatment of diabetes. Insulin is a major protein hormone secreted by beta –cells of the pancreas and is important for the control of diabetes. Insulin has an important place in drug therapies for insulin dependent diabetes mellitus (type I) and for many patients with non-insulin-dependent diabetes mellitus (type II). It would be highly advantageous if insulin could be administered orally, because the oral delivery of insulin can mimic the physiological fate of insulin and may provide better glucose homeostasis. The desire to deliver protein and peptide biopharmaceuticals conveniently and effectively has led to the intense investigation of targeted delivery systems. The goal of oral insulin delivery devices is to protect the sensitive drug from proteolytic degradation in the stomach and upper portion of the small intestine.

SMEDDS A NOVEL APPROACH TO IMPROVE BIOAVAILABILITY: A REVIEW

About Authors:
Anoop Patel*1, Anoop Kumar1, Neha Sharma1, Monika Prajapati2
1Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, U.P., India
2Raj Kumar Goel institute of technology, 5th K.M. Stone Delhi Meerut Road, Ghaziabad, Uttar Pradesh- 201003
*anoop.p.2007@gmail.com

ABSTRACT:
Oral route still remains the favorite route of drug administration in many diseases because it is very suitable for drug delivery and non invasive. Till today it attracts to many researchers for investigation in the development of new dosage forms. The major problem in oral drug formulations is low and erratic bio-availability due to less water solubility and permeability of the drug across the biological membrane. This may arise high inter and intra subject variability due to lack of dose proportionality and therapeutic failure. It is estimated that 40% of new active constituents which are investigated recently show poor water solubility due to their lipophilic nature. The improvement of bio-availability of these drugs with such properties presents one of the greatest challenges in drug formulations. Several technologies are used for overcome these problems including micronization, solid dispersions, cyclodextrins complex formation and different lipid based drug delivery systems. Self-emulsifying drug delivery system is one the most important and advanced technology for enhancing the oral bio-availability as well reducing in dose. This system also gained attraction for enabling more consistent drug absorption, selective targeting of drugs in GIT, and protection of drugs from the inner environment of gut.

NASAL DRUG DELIVERY SYSTEM: A COMPLETE REVIEW

About Authors:
Dharmendra Kumar*1, Sumedha Bansal1
1Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology,
Meerut, Uttar Pardesh, India, 250005
*rvnimiet@gmail.com

Abstract:
In present era, nasal drug delivery system has been considered as potential and favourable route of drug delivery because it provides patient compliance, easy to administration, bypass first pass metabolism, excellent penetration, low dose required, rapid absorption and gives desirable effects. So many times nasal drug delivery has been considered as alternative of parenteral route. The purpose of this review, to provide a complete information about nasal drug delivery system such as advantage, limitations, anatomy of nose, mechanism of drug absorption, factors affecting of nasal drug delivery, absorption improvement aspects, novel drug formulations, types of nasal drug delivery system with uses of nasal drug delivery in various disease. So we have expectation, that researches and others cited person get benefitted from this review.

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