Meerut

BIT Group of Institutions invites Directors, Professors, Associate Professors, Assistant Professors for Pharmacy

BIT was established in the year 2001 to spread knowledge in the fields of Engineering &Technology, Pharmacy and management Education by a group of illustrious entrepreneurs under the name Space Age Research and Technology Foundation Charitable Trust. BIT Group of Institutions having four Schools stands amongst the renowned Management and Technical Education Centre imparting courses catering to the needs of industry and providing contribution in the field of consultancy and research.

ROLE OF CHROMATOGRAPHY IN EVALUATION OF HERBAL DRUGS: A SHORT REVIEW

About Author:
Alimuddin Saifi
N.K.B.R. College of Pharmacy & Research Centre,
Meerut
asaifi2005@gmail.com

Abstract
Herbal drugs are accepted as important therapeutic agents for the treatment of many diseases. The development of authentic analytical methods which can reliably profile the phytochemical composition, including quantitative analyses of marker/bioactive compounds and other major constituents, is a major challenge to scientists. Pharmacognostical analysis of medicinal herbs remain challenging issues for analytical chemists, as herbs are a complicated system of mixtures. Analytical separation techniques for example high performance liquid chromatography (HPLC), gas chromatography (GC) and mass spectrometry (MS), High Performance Thin Layer Chromatography (HPTLC) etc. among the most popular methods of choice used for quality control of raw material and finished herbal product.

NOVEL FAST DISSOLVING TABLETS: A COMPREHENSIVE REVIEW

About Authors:
Tyagi Nitin*, Singh Vikram Jeet, Mishra Santosh Kumar
CARPS, Faculty of Pharmaceutical Sciences, Shobhit University,
Meerut, U.P.(250110), India.
*nitintyagi27@yahoo.in

Abstract
These tablets were introduced in 1980s in the market  and since their introduction in the market the fast dissolving tablets are gaining popularity regularly. Due to their rapid disintegration or dissolution in the oral cavity as they come into contact of saliva normally with in one minute, without the use of water these provides patient compliance particularly to the pediatric, geriatric ,bedridden patients and for patients who are very much busy in travelling and does not have easy access to water. The present article aims on the recent advancements in the fast dissolving tablets and provides a good information about the advantages,limitations, mechanism of action of superdisintegrants, the conventional and patented development techniques and about the evaluation parameters of the fast dissolving tablets.

ALTERING STATE OF AFFAIRS OF PACKAGING IN PHARMACEUTICAL INDUSTRY: A REVIEW

About Authors:
Nishant kumar gupta, *Aadesh kumar
Dept. of pharmacy BIT meerut
*adesh.adi.chaudhary@gmail.com

Abstract:
There was a point in time when packaging in pharmaceutical industry is symbolized for substantial safeguard, for identification and for merely endowing with a piece of information to any person who agree to it. But the changing scenario has been conveyed an assortment of changes, as in this day and age packaging provides the prevention of product tampering and counterfeiting, the assurance of product dispensing accuracy, child protection and the promotion of patient compliance with product dosage schedules. In the precedent time we used packaging materials, labels, holograms and some introductory communications; but these days together with them we use mobile applications, an innovative and creative unit, altering labeling standards, luxurious packaging, a packaging development team, anti-counterfeiting packaging extravaganza, hi-tech module for packaging demonstrate and an intelligent outlook. Packaging schoolwork has such an individual place in the market of counterfeit or fake drugs as nowhere. Packaging developer has an only effort to engender a special design that can competent with both fake brands and generic brand of that drug with ‘Me-too’ names.

PREPARATION AND EVALUATION OF BIODEGRADABLE ALBUMIN MICROSPHERES OF DICLOFENAC SODIUM

About Authors:
Renu1*, Shashi Kant2*, Rajendra Yadav3, Amit Kumar Tyagi4
1Faculty of Pharmacy, Shivdan Singh Institute of Technology and Management, Aligarh (U.P)
2Jubilant Chemsys Ltd, Noida,
3Department of Pharmaceutical Sciences, Gurukul Kangri University Haridwar, 
4Department of Chemistry, Meerut College, Meerut (U.P)
*shashi.pharma83@gmail.com

ABSTRACT :
Diclofenac is currently the eighth largest-selling drug and the most frequently used NSAID (Non-steroidal anti-inflammatory drug) in the world, since its introduction in Japan in 1974. Diclofenac is among the better tolerated NSAIDs. Only major adverse effect of Diclofenac is that it causes direct and indirect irritation of the gastrointestinal tract (GIT). To reduce the side effects on gastrointestinal tract (GIT) and to improve therapeutic efficacy of Diclofenac, it can be formulated in polymeric microspheres.
The use of polymeric carriers in formulations of therapeutic drug delivery systems has gained widespread application, due to their advantage of being biodegradable and biocompatible. Among the microparticulate systems, microspheres have a special importance since it is possible to target drugs and provide controlled release. Diclofenac sodium (DS), is a potent drug in the NSAID group having non-steroidal, anti-inflammatory properties, and is widely used in the treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. In this present study, it was aimed to prepare microsphere formulations of DS using a natural biodegradable polymer as a carrier for administration to extend the duration period of the dosage form. Microsphere formulations of DS which were prepared were evaluated in vitro for particle size, yield value, encapsulation efficiency, surface morphology, and in vitro drug release.

RECENT ADVANCEMENTS: MICROSPONGE DRUG DELIVERY SYSTEM; A REVIEW

About Authors:
Deepak Sharma*, Arunabha Banik, S k Gupta
Department of Pharmaceutical Technology,
MIET,Meerut
*thakraan.southcarolina@gmail.com

ABSTRACT
The Microspongesdelivery system are extremely small, inert,indestructibleclusters of even tinierspherical particles of microscopic sizepatented polymeric delivery systems consisting of porous microspheres that can entrap a wide range of active ingredients such as emollients, fragrances, essential oils, sunscreens, and anti-infective, anti-fungal, and anti-inflammatory agents and are very well tolerated, and highly efficacious, novel productsthat do not pass through the skin, capable of holding four times their weight in skin secretionsand can absorb skin secretions. Like a true sponge, each microspheres consists of a myriad of interconnecting voids within a non-collapsible structure with a large porous surface. The size of the microsponges can be varied usually from 5-300µm in diameter, depending upon the degree of smoothness or after-feel required for the end formula. Although the microsponge size may vary, a typical 25µm sphere can have up to 250000 pores and an internal pore structure equivalent to 10ft in length providing a total pore volume of about 1ml/g. This results in a large reservoir within each microsponge, which can be loaded with up to its own weight in active agent. The microsponge particles themselves are too large to be absorbed into the skin and this adds a measure of safety to these microsponge materials. Another safety concern is the potential bacterial contamination of the materials entrapped in the microsponge. Because the size of the pore diameter is smaller than bacteria, ranging from 0.007 to 0.2µm, bacteria cannot penetrate into the tunnel structure of the microsponges.The microsponge system can prevent excessive accumulation of ingredients within the epidermis and the dermis. Potentially, the microsponge system can reduce significantly the irritation of effective drugs without reducing their efficacy.

Nanotechnology, an emergent field in drug delivery with potential to alleviate life threatening disease – A REVIEW

About Authors:
Aadeshkumar*, Nishantkumar gupta, Dineshkumar gupta
Dept. of pharmacy
BIT meerut, UP
*adesh.adi.chaudhary@gmail.com

ABSTRACT
In recent years there has been a rapid increase in nanotechnology in the fields of medicine and more specifically in targeted drug delivery. The proprietary powder processing techniques use by nanotherapeutics improves the delivery of drug that can not normally taken orally.
It improves
·         Safety and efficacy of low molecular weight drugs,
·         Stability and absorption of proteins that normally cannot be taken orally,
·         Extend the life cycle of existing drug formulation.

At present many substances are under investigation for drug delivery and more specifically for cancer therapy, AIDS and potential to cross the Blood Brain Barrier (BBB) has open new ways for drug delivery into the brain. Pharmaceutical sciences are also using nanoparticles to reduce toxicity and side effects of drugs. Nanoparticles are also have the potential as novel intravascular or cellular probes for both diagnostic and therapeutic purposes (drug/gene delivery) and nanosize allow access into cell and cell compartment including nucleus. . Discovery of nanomedicine has given rise to nanoparticles through which better target specific drug and gene delivery is possible. In conclusion nanoparticles for drug delivery and imaging have gradually been developed as new modalities for cancer therapy and diagnosis. This review illustrates the emerging role of nanotechnology in drug delivery.

SELECTIVE ESTROGEN RECEPTOR MODULATORS: ANTIBREAST CANCER AGENTS

About Authors:
Rawat Pinki1*, Rawat Preeti2, Kumar Piyush3 Kanoujia Jovita3, Singh Sangeeta 1
1. Institute of Pharmaceutical Science and Research, Unnao, U.P., India.
2.  L.T.R. College Of Technology, Meerut, U.P., India.
3. Curadev Pharmaceuticals Ltd., Kanpur, U.P., India.

*pnkrawat@gmail.com

Abstract:
Selective estrogen receptor modulators, called SERMs for short, blocks the naturally circulating estrogen in breast tissues and other estrogen-sensitive tissues in the body. Each estrogen receptor has a slightly different structure, depending on the kind of cell it is in. If a SERM binds to a estrogen receptor, there is no site available for estrogen to bind and it can't attach to the cell. SERMs are called "selective" because they bind to particular estrogen receptors. This selective binding action is sometimes called estrogen inhibition, or estrogen suppression.

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