S.Dinesh*, M.Senthil Kumar, Ashok kumar, Hariharan, jenish, Marshal joseph
Annai veilankanni’s pharmacy college
saidapet, chennai – 600 015.
Tamil nadu, pin:600015
Cinitapride1-2, chemically4-amino-N[3-(Cyclohexan-1-yl-methyl)-4-piperidinyl]-2-ethoxy-5-nitrobenzamide has the molecular formula C21H30N4O4 and molecular weight 402.49 g.Cinitapride is a drug that has against action to the serotoninergic 5-HT2 and D2 dopaminergic receptors that has been indicated in the gastro esophageal reflux and in the functional disorders of gastrointestinal motility treatment, The present study was aimed to formulate and evaluvate the tablets containing Cinitapride based on floating technique in order to increase gastric retention time, Total 9 formulation (F1-F9)were done using 3 different polymers like (HPMC k4m, HPMC e15m and HPMC k100m ). The formulations prepared were subjected to dissolution tests for 12 hrs, Among all the 9 formulation formulation (F5) were able to efficiently control Cinitapride release over a time period of 12 hrs. Thus the results of the current study clearly indicate, a promising potential of the floating tablet as an alternative to conventional dosage form.