Tamil Nadu

FORMULATION AND INVITRO EVALUATION OF 5-FLUOROURACIL MICROCAPSULES BY USING DIFFERENT METHODS OF MICROENCAPSULATION

ABOUT AUTHORS:
S.Shanmugam1, J. Srikanth Reddy*1, T. Vetrichelvan2
Adhiparasakthi College of Pharmacy,
Melmaruvathur, 603 319, Tamilnadu, India.
*srikanthjeedipelly@gmail.com

ABSTRCT:
The present study in formulation and evaluation of 5-fluorouracil microcapsules. 5-fluorouracil which is used as a anti cancer drug to treat cancer. The capsules were prepared by coacervation phase separation and emulsion solvent evaporation by using gelatin, sodium alginate and ethyl cellulose. The prepared microcapsules were evaluated with various evaluation methods such as drug content, in-vitro drug release studies, kinetic studies and stability studies as per ICH guidelines were performed. The formulated extended release microcapsules were prepared by powder layering technique. In these formulations containing 150mg of 5-fluorouracil was loaded in it. The particle size and dissolution study of  F9 formulation was concluded as the best formulation among other formulations, which showing the most desired drug release. It will be considered as optimized formulation. No significant change was observed in the drug content physical properties and dissolution rate of these micro pellets after the storage period of three months at 40±2ºc and 75±5%RH.

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