S.R.V.Vivekananda Rao*, K.Sundaramoorthy, T.Vetrichelvan
Department of Pharmaceutics, Adhiparasakthi College of Pharmacy,
Melmaruvathur-603319, Kanchipuram (Dist),
The work was aim to formulate and evaluate mucoadhesive microspheres of Metronidazole for treatment of Amoebiasis and other protozoal infections by combine the potential advantages of mucoadhesion with sustained drug delivery using various ratio of polymers. Mucoadhesive microspheres were prepared by orifice ionic gelation method. Microspheres were found discrete, spherical and free flowing. The microspheres exhibits good mucoadhesive property in vitro wash off test and showed high drug entrapment efficiency. Metronidazole release from these microspheres was slowed, sustained on the type of polymers used. The formulation f9 was showed consistent drug release up to 10 hr time period. Among all the formulations, f9 containing sodium alginate and methyl cellulose showed the reproducible result with best mucoadhesive profile and good surface morphology. The work has demonstrated that among all the formulations of microspheres, particularly those of formulation f9 are promising candidates for the sustained release of Metronidazole.