Tamil Nadu

FORMULATION AND IN-VITRO EVALUTION OF METRONIDAZOLE MUCOADHESIVE MICROSPHERES

ABOUT AUTHORS:
S.R.V.Vivekananda Rao*, K.Sundaramoorthy, T.Vetrichelvan
Department of Pharmaceutics, Adhiparasakthi College of Pharmacy,
Melmaruvathur-603319, Kanchipuram (Dist),
Tamilnadu, India.
*viveksrv1989@gmail.com

ABSTRACT
The work was aim to formulate and evaluate mucoadhesive microspheres of Metronidazole for treatment of Amoebiasis and other protozoal infections by combine the potential advantages of mucoadhesion with sustained drug delivery using various ratio of polymers. Mucoadhesive microspheres were prepared by orifice ionic gelation method. Microspheres were found discrete, spherical and free flowing. The microspheres exhibits good mucoadhesive property in vitro wash off test and showed high drug entrapment efficiency. Metronidazole release from these microspheres was slowed, sustained on the type of polymers used. The formulation f9 was showed consistent drug release up to 10 hr time period. Among all the formulations, f9 containing sodium alginate and methyl cellulose showed the reproducible result with best mucoadhesive profile and good surface morphology. The work has demonstrated that among all the formulations of microspheres, particularly those of formulation f9 are promising candidates for the sustained release of Metronidazole.

5 (Five) BSR Meritorious Fellowships to Madurai Kamaraj University

Madurai Kamaraj University, established in 1966, has 18 Schools comprising 73 Departments. The Directorate of Distance Education of the University has a student strength of about 1.30 lakhs. The University has 109 affiliated Colleges (9 Autonomous) including other approved institutions and 7 evening colleges. There are centres which promote research potential of teachers. Extension activities are carried out through Department of Youth Welfare, NSS, SC/ST cell and Adult Education programmes.

A STUDY OF EPIDEMIOLOGY WHICH INVOLVES MONITORING INFORMATION REGARDING EMERGING & REEMERGING COMMUNICABLE DISEASES IN GOVERNMENT HOSPITAL

ABOUT AUTHORS:
Mr. R. Krishnaswamy, Dr.R.Sampathkumar, Mr.N.Venkateswara Murthy, Mr. Anton Vinoth.T
Department of Pharmacy Practice J.K.K.Naatraja College of Pharmacy,
Komarapalayam, Tamilnadu.
*krishnasamy1993@gmail.com

ABSTRACT
To make decisions regarding the control of communicable diseases and to reduce the epidemic situations, this article has been presented in the way of studying about the epidemiology which involves monitoring information regarding emerging & reemerging diseases, its causative agents, treatment etc., This article also relates studying about mode of transmission(through vector (or) through contact) which helps in making decisions regarding its prevention and to prevent its spreading.

MOLECULAR CHARACTERIZATION OF CERTAIN GYMNEMA SYLVESTER ECOTYPES THROUGH RAPD ANAYLYSIS

ABOUR AUTHORS:
G.M.Reddy, *D.Gopi Krishna
Sathyabama University
Chennai, TN, India
*gopikrishnamsc@yahoo.com

ABSTRACT
Gymnema sylvestre is a large, stout, woody , vine-like plant which climbs on bushes and trees. It is known in sankrit- meshashiringi, madhu nashinin (madhu=sugar, nashini= destroy), in telugu- podapatri, in hindi- gur-mar. the latin name of gymnema sylvestre means  “ sugar destroyer” and is considered a herbal remedy for high blood sugar. traditionally it was recommended for stomach problems, constipation,  water retention and liver disease but the recent studies conducted in india have further shown that extract of gymnema sylvestre is useful in controlling bloodsugar to treat type-ii diabetes. gymnema has been clinically proven to reduce excessively high blood sugar levels, perhaps as a result of boosting the production of insulin required to process sugar.

A REVIEW ON: WATER ANALYSIS IN PHARMA INDUSTRIES

ABOUT AUTHORS:
Narasimha Gandhi1, Ravisankar M*1, Harini K2, Ananda Thangadurai S2
1Kemwell bio pharma pvt ltd, Neelamangala, Bangalore.
2Swami Vivekanandha College of Pharmacy, Department of Pharmaceutical analysis,
Elayampalayam, Thiruchengode, Namakkal Dt.
*pharmaravi18@gmail.com

ABSTRACT
In today’s pharmaceutical facilities the availability of purified water is essential. While the domestic consumer considers tap water to be pure the pharmaceutical end-user regards it as grossly contaminated. Within the pharmaceutical industry, water is most commonly used in liquid form, not only as an ingredient in many formulations but also as a cleaning agent. Production of Purified Water, Highly Purified Water, Pyrogen Free Water and WFI to international pharmaceutical standards is widely recognised as a critical process. This review article describes about the purification process and critical factors involves in the purified water.Purified water is used in most Pharmaceutical manufacturing processes all around the world. Therefore, international and national authorities have established water quality standards for purified and other regulated grades of water. Key authorities include the United States Pharmacopoeia (USP), the European Pharmacopoeia (Ph Eur), the Japanese Pharmacopoeia (JP) The standards in this section are a summary and correct at the time of going to press. Standards are regularly reviewed and updated and users should refer to the latest version of the full standards.

STABILITY STUDY OF CEFOTAXIME SODIUM BY STABILITY INDICATING METHODS

ABOUT AUTHORS:
Sundara Raj Behin1*, Isaac Samraj Punitha2, Sankara Subramaniyan Krishnan3
1Department of Pharmaceutics, Shree Devi college of Pharmacy, Airport Road, Kenjar, Mangalore, Karnataka – 574 142.
2Department of Pharmacognosy, Shree Devi college of Pharmacy, Airport Road, Kenjar, Mangalore, Karnataka – 574 142.
3Department of Pharmaceutics, Sri Ramakrishna Institute of Paramedical sciences, 395, Sarojini Naidu Road, Coimbatore, Tamilnadu.
*behin1@googlemail.com

ABSTRACT
Stability indicating assay methods were developed and compared for Cefotaxime Sodium. The influence of temperature and relative humidity on the stability of cefotaxime sodium in continuous infusion was investigated. The physical and chemical stability of cefotaxime sodium was determined at three different temperatures (5°C/60%RH, 25°C/60%RH, and 45°C/75%RH) and changes in the concentration of cefotaxime sodium were followed by HPTLC and microbiological assay methods. The physical stability parameters of colour change and pH were calculated. The drug solutions were clear and pale yellow initially with the intensity increasing by time, eventually becoming reddish yellow. HPTLC analysis indicated that 100mg/ml concentration of cefotaxime sodium maintained adequate stability for 2 hours at 45°C and up to 24 hours at 25°C and up to 5 days at 5°C. By microbiological assay method we found that cefotaxime sodium was stable for three days at 5ºC, one day at room temperature and four hours at 45ºC.

Vacancies for Junior Research Fellow in Alagappa University | Walk in

Alagappa University accredited with 'A' Grade by National Assessment and Accreditation Council (NAAC) is located at Karaikudi in Tamil Nadu is accessible from Madurai and Tiruchirappalli Airports within two hours. The 440 acre green and lush campus houses all the academic activities. This University has emerged from the galaxy of institutions initially founded by the great philanthropist and educationist Dr. RM. Alagappa Chettiar.

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