NEIGRIHMS was established by the Government of India in 1987. It has been designed as a Postgraduate Medical Institute in lineage of AIIMS, New Delhi and PGIMER, Chandigarh. It is the First Postgraduate Medical Institute in the North Eastern Region and the Third in the Country established by Ministry of Health and Family Welfare, Government of India. The Institute was registered as a Society on 12th January 1987 by the Registrar of Societies, Meghalaya, Shillong under the name of - “North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences”

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ABOUT AUTHORS:
Alti Aparna^1*, Seema Pushpa Latha¹, Gopalgari Lakshmi Nagarjun¹, Galammagari Nagaraju¹, C. Gopinath¹, P. Murali Madhav^2
1Annamacharya College of Pharmacy, Kadapa, Andhra Pradesh.
²Rajiv Gandhi Institute of Medical Science, Kadapa, Andhra Pradesh.
aparna.althi@gmail.com

ABSTRACT
Introduction: Diabetes mellitus is on alarming rise in India. Drug utilization studies help to identify the adherence to standard guidelines and extent of drug use and to evaluate the rational drug usage.
Aims and objectives: To determine the drug utilization pattern and effectiveness of oral hypoglycemic agents among diabetes mellitus patients.
Materials and methods: It is a prospective observational study carried out for a period of six months at RIMS kadapa, and two others diabetic centers. The diabetic patients who visited the medicine outpatient department were included. After obtaining approval from institutional ethical committee, a structured data collection form was used to collect demographic data, complete prescription details and other relevant information required for the study. The drug utilization pattern was determined. The drugs were categorized by Anatomical therapeutic classification (ATC) and DDD/1000 inhabitants/day was calculated by using WHO guidelines. Among all oral hypoglycemic agents the most effective drug/combination in this region was identified.
RESULTS:  716 prescriptions were assessed out of which,401(56.0%) were females and 315(43.9%) were males, most of the patients were in the age group of 40-60 for males 175(55%) and females 205(51.1%). Hypertension was the most common co-morbid seen. The average number of drugs per prescription was 4.26 and anti-diabetics per prescription was 1.79. DDD/1000 inhabitants/day for metformin (A10BA02) was 10.5, glimiperide (A10BB12) was 9.3, glibenclamide (A10BB01) was 7.91, pioglitazone (A10BG03) was 7.25. Out of 716 patients 311(45.25%) patients were on Monotherapy, and 405 (56.5%) were on Combination therapy.A total of 200 newly diagnosed patients of diabetes mellitus were enrolled in the study out of which only 128 members were followed up successfully. The combinations of Metformin +Sulfonyl Ureas + Others showed a good control of fasting blood sugar when compared with only Metformin, only Sulfonyl Ureas or Metformin +Sulfonyl Ureas, Sulfonyl Ureas + Others.
Conclusion: Metformin was the most utilized drug followed by glimiperide. Combination therapy was most frequent when compared to monotherapy in which metformin+glimiperide was commonly prescribed one. so by understanding  the current prescribing patterns attempts can be made to improve rational prescribing. The combination of Metformin+Sulfonyl Ureas+Others is more effective combination.

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ABOUT AUTHORS:
Priyanka P. Atodariya*, Hasumati A. Raj, Vineet C. Jain
*Shree Dhanvantary Pharmacy Collage, Kim,
Surat, Gujarat, India
*atodariya.priyanka@yahoo.com

ABSTRACT:
The simple spectroscopic method has been developed for simultaneous estimation of Lamotrigine and Clozapine in synthetic mixture. Absorbance Correction Method involves the measurement of absorption at two wavelengths 307 nm (l_maxfor Lamotrigine) and 360 nm (l_max for Clozapine). The method was found linear between the range of 1-5 µg/ml for Lamotrigine and 6-30 µg/ml for Clozapine for method. The accuracy and precision was determined and validated statistically. Both the method showed good reproducibility and recovery with %RSD less than 1. The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis for Lamotrigine and Clozapine in bulk and combined dosage form.

ABOUT AUTHORS:
Prakash T. Sangale*¹, Dhananjay B. Deshmukh², Rajesh Bhambere^3
1Department of Quality Assurance Techniques,
²Department of Pharmacology,
VJSM’S Vishal Institute of Pharmaceutical Education and Research,
Ale, Junnar, Pune
*prakashsangale091@gmail.com
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ABSTRACT
Epilepsy is a chronic disorder characterized by the occurrence of epileptic seizures, with or without characteristic body movements (convulsion)affecting about 50 million people worldwide. Synthetic drugs for the treatment of epilepsy are associated with severe side effects and addiction liabilities upon long term uses. Thus, researchers around the globe are searching for natural resources.Erythrinavariegata and Butea monosperma is a traditional medicinal plant used to treat a seizure.The present studies reveal that the anticonvulsant activity by Erythrina variegate & Butea monosperma of bark & leaf PTZ and MES induced convulsions in wistar rats using Erythrina variegata & Butea monosperma of bark & leaf ethanolic extracts extracted successively. However, the anticonvulsant activity of this plant has not been studied in depth.

In Pentylene tetrazole (PTZ) an maximal electro shock seizure(MES) models test parameters like latncy, onset of tonic convulsions, clonic convulsions and percent protection were observed in the different test groups. Inconclusion, we showed that the ethanolic extract of Erythrina variegata and Butea monosperma has anticonvulsant effect in the both models, suggesting their possible depressant action in the central nervous system. EEBM and EEEV gave significant protection (P<0.001) against PTZ & MES induce convulsion.

CSIR-Indian Institute of Integrative Medicine, Jammu, has created a State of the Art National Facility namely cGMP pilot Plant for Extraction, Formulation and Packaging of Traditional (ISM) Herbal Medicinal formulations to prepare formulations in the form of a tablet/capsule/liquid, of the extracts and botanical derived APIs for preclinical and clinical trials in accordance with the requirements of regulatory agencies to develop new rational drug formulations, desires to recruit Quality Assurance expert/consultant and Plant Operators on purely temporary basis in the Institute as under:-

Post: Quality Assurance Expert/consultant

Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram is an Institute of National Importance  established by an Act  of the Indian Parliament  and  under the 2 administrative control of the Department of Science and Technology, Government of India.
The Institute signifies the convergence of Medical Sciences and Technology and its mission is to enable the indigenous growth of biomedical technology, besides demonstrating high standards of patient care in medical specialties and evolving postgraduate training programs. It has a hospital for tertiary care of cardiovascular and neurological diseases, and research programmes in the areas of basic and applied medical sciences,  a Biomedical Technology Wing with facilities  and research programmes for developing medical  devices from a conceptual stage to commercialization, and The Achutha Menon Centre for Health Science Studies for training and research in public health.

For a DBT Project entitled “Mechanism of epileptogenesis in young and adult brain-Role of NMDA receptor subtypes in hippocampal neurons and astrocytes” (P-8084)

Post: Project Assistant

National Health Mission (NHM), Rajasthan State Health Society, invites applications for various positions of Managers/Consultants/Ofificers/Coordinators and Assistants at State HQ on contractual basis under National Rural Health Mission (NRHM) Rajasthan.

The details of various positions, required essential qualifications & experience, maximum age limit etc.are as under:

Post: Logistic Manager, Consultant

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ABOUT AUTHORS:
*Ashif I. Bhim¹, Farhana V. Buchiy¹, Hasumati A. Raj¹, Vineet C. Jain^2
1Department of Qaulity Assurane, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India.
²Department of Pharmacognocy, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India.
bhimiqbal23@gmail.com

ABSTRACT
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Itopride Hydrochloride and Lansoprazole in synthetic mixture using first order derivative zero-crossing method. Itopride Hydrochlorideshowed zero crossing point at 278.12nmwhile Lansoprazole showed zero crossing point at 244.58nm. The dA/dλ was measured at 244.12 nm for Itopride Hydrochloride and 278.12nmfor Lansoprazole and calibration curves were plotted as dA/dλ versus concentration, respectively. The method was found to be linear (r2>0.999) in the range of 5-25μg/ml for Itopride Hydrochloride at 244.58nm. The linear correlation was obtained (r2>0.996) in the range of 5-25 μg/ml for Lansoprazole at 278.12 nm. The limit of determination was 0.155μg/ml and 0.059μg/ml forItopride Hydrochloride and Lansoprazole, respectively. The limit of quantification was 0.472μg/ml and 0.179μg/ml for Itopride Hydrochloride and Lansoprazolerespectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows first order derivation zero crossing. The method was successfully applied for simultaneous determination of Itopride Hydrochloride and Lansoprazolein binary mixture.

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ABOUT AUTHORS:
Chetna V. Karchaliya*, Parula B. Patel
Department of Quality Assurance,
S. J. Thakkar Pharmacy College,
Rajkot, Gujarat, India
*sonichetna158@gmail.com

ABSTRACT:
The simple, accurate and precise Absorption Correction Method has been developed for the simultaneous estimation of Amitriptyline hydrochloride and Methylcobalamin in combined tablet dosage form. The method utilizes distilled water as solvent and λmax of Amitriptyline hydrochloride and Methylcobalamin selected for analysis were found to be 239 nm and 351 nm respectively. The method was validated as per International Conference on Harmonization (ICH) guidelines. The Linearity range lies between 20-60 µg/ml (R² 0.9998) for Amitrityline hydrochloride and 3-9 µg/ml (R² 0.9990) for methylcobalamin. The accuracy and precision were determined and found to comply with ICH guidelines. The method showed good reproducibility and recovery with %RSD in desired range. The proposed method can be applied for routine analysis of both drugs.

ABOUT AUTHOR:
Vinay Kumar Singh
General Manager-Technical,
Mikasa Cosmetics Limited,
Ahmedabad, Gujarat
vinay.s@mikasacosmetics.com

To understand Ayurvedic Cosmetics one must think as to what is the synergy between Ayurveda and Cosmetics. The word ‘cosmetics’ is derived from the Greek word ‘kosmeticos’ which means skill decoration or skill in arranging in order or correcting the deformities. Cosmetics is applied topically to skin and its appendages to cleanse, decorate, beautify, alter the appearance and ultimately to enhance confidence of user.

Jodas India is manufacturing and sourcing arm of Moscow (Russia) based Jodas Expoim. Till date, most of the Jodas’s products are manufactured in India.

Post: Deputy Manager - Production (1)

Macleods, India's Fastest growing pharmaceutical company, with a strong R&D, manufacturing sites ranked among the top pharmaceutical companies presently operating in more than 50 countries worldwide, requires talented professionals

Post: Research Scientist, Officer/Executive

The Sai Clinical Research Training Institute is a unique year-long education and mentoring program for hematology fellows and junior faculty at academic medical centers and offers a broad education about clinical research methods, research collaborations, statistical analysis, and managing the demands of family and career.
The goal of Sai Clinical Research Training Institute is to produce a group of researchers armed with ideas for clinical hematology research and the tools and access to resources to make their ideas a reality.

Post: Bio Analytical Research Analyst

HealthKartPlus is India's first and only Generic Drug Search Engine which enables you to find the best medicine for your treatment. It includes most of the brands as well as their generic equivalents which are cost effective.
HealthKartPlus is a highly functional application which acts as a search engine which is free of cost and is easily accessible. This revolutionary step aids in educating the consumers, providing them with the best alternative medicines to choose from.

Post: Retail Pharmacist

The Walk-in-Interview for the positions of Post Doctorate Fellows/Research Associate/ Senior Research Fellows/Junior Research Fellows and Field Investigator in below mentioned project/scheme will be conducted at this Institute on the date/time and venue and other details shown against positions on contractual basis, which is co-terminus with the project/scheme. The eligible candidates are invited to appear before the Selection Committee for Walk-in-Interview at NDRI, Karnal.

Post: Senior Research Fellow

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ABOUT AUTHORS:
Nidha Amir*, Mohd Mazhar, Abhinav Sawhney, S.K Rajput
Department of Pharmacology
Amity Institute of Pharmacy, Amity University, NOIDA, Uttar Pradesh-201313, India
nidha.amir05@gmail.com

ABSTRACT
Fluorine, the 13th most abundant element of the earth’s crust, represents about 0.3g / kg of earth’s crust. It occurs mainly in the form of chemical compounds such as sodium fluoride or hydrogen fluoride, which are present in minerals fluorospar, fluorapatite, topaz and cryolitect. Fluoride is frequently encountered in minerals and in geochemical deposits and is generally released into subsoil water sources by slow natural degradation of fluorine contained in rocks. Fluoride being a natural element has several effects on health. Fluoride is beneficial to health if the concentration (CF) of the fluoride ion (F-) in drinking water is less than 1.5 mg/L (WHO 1994). A higher concentration causes serious health hazards. The disease caused manifests itself in three forms, namely, dental, skeletal, and non-skeletal fluorosis. On a large scale, it is used in dental product due to its anti- sensitizing property and abrasive action. Application of fluoride must be controlled and restricted to reduce the side effect induced by it.