Articles

About Authors:
Manu Arora^1*, Amanpreet Singh²
School of Pharmacy & Emerging Sciences,
Baddi University of Emerging Science & Technology,
Makhnumajra, Baddi, Distt. Solan,
Himachal Pradesh-173205, India.
*manu_cognosy@yahoo.co.in

ABSTARCT
Mimosa pudica is a weed which is commonly known as chuemue (touch me not) belongs to the family Leguminaceae.  It is found in moist and waste places. Chuemue shows nyctynastic and seismonastic movement. All parts of this plant possess different medicinal properties like dysentery, leprosy, asthma, sedative, emetic and tonic. Its aerial parts contain different secondary plant metabolites like tannins, alkaloids, glycosides, Flavonoids and saponins. This review shows presence of secondary plant metabolites and its ethnopharmacological uses.

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About Author:
Tarika Priya
SLC's college of pharmacy. JNTUH
Hyderabad-500076
a4aryatarikapriya@gmail.com

1. Abstract
The aim of study was to screen the antibacterial and antifungal activities of methanol and ethanol extracts of fenugreek seed (Trigonella foenum). Crude extracts of the seeds with methanol and ethanol were screened for antibacterial activities against two gram positive pathogenic bacteria – Bacillus subtilis, Staphylococcus aureus and against two gram negative pathogenic bacteria – E.coli, klebsiella. The antibacterial activity was performed using cup-plate method. The extracts were prepared using soxhlet extraction method. Methanol extract showed activity against E.coli and Klebsiella were as ethanol extract showed activity against Staphylococcus and Bacillus spp.,

The anti fungal activity was also screened against Aspergillus niger. Both the extracts showed good activity against the fungi.
The results obtained in the present study suggest that the extracts revealed a significant scope to develop a novel broad spectrum of antibacterial herbal formulations.

About Authors:
Aadeshkumar*, Nishantkumar gupta, Dineshkumar gupta
Dept. of pharmacy
BIT meerut, UP
*adesh.adi.chaudhary@gmail.com

ABSTRACT
In recent years there has been a rapid increase in nanotechnology in the fields of medicine and more specifically in targeted drug delivery. The proprietary powder processing techniques use by nanotherapeutics improves the delivery of drug that can not normally taken orally.
It improves
·         Safety and efficacy of low molecular weight drugs,
·         Stability and absorption of proteins that normally cannot be taken orally,
·         Extend the life cycle of existing drug formulation.

At present many substances are under investigation for drug delivery and more specifically for cancer therapy, AIDS and potential to cross the Blood Brain Barrier (BBB) has open new ways for drug delivery into the brain. Pharmaceutical sciences are also using nanoparticles to reduce toxicity and side effects of drugs. Nanoparticles are also have the potential as novel intravascular or cellular probes for both diagnostic and therapeutic purposes (drug/gene delivery) and nanosize allow access into cell and cell compartment including nucleus. . Discovery of nanomedicine has given rise to nanoparticles through which better target specific drug and gene delivery is possible. In conclusion nanoparticles for drug delivery and imaging have gradually been developed as new modalities for cancer therapy and diagnosis. This review illustrates the emerging role of nanotechnology in drug delivery.

About Authors:
Singh Asheesh^1*, Bajpai Dinesh¹, Singour P.K.^2
1Centre for Research & Development, Ipca Laboratories Ltd; Sejavta; Ratlam (MP) - 457002
²Faculty of pharmacy VNS Institute, Neelbud Bhopal (MP) - 462042
*asheesh_parihar@yahoo.com

Abstract:
Stevia rebaudiana is a well known medicinal herb contains antibacterial, antifungal, anti-inflammatory, anti-viral, anti-yeast, cardiotonic diuretic and hypoglycaemic properties. This herb has been used in Ayurveda in India since centuries. Stevia is a perennial herb belonging to the family Asteraceae, is one of the most valuable tropical medicinal plant. All over world there is increasing tendency towards consuming natural products and thus living a natural life and. At the same time our life styles have changed so much over the last 4-5 decades that sweeteners (either high calorie natural or proceeded sugars or high potency and low calorie sweeteners such as Aspartame) have become integral part of our natural daily diet. Stevia is a new crop in that is gaining very high popularity amongst all type of sweetener users as most ideal substitute for sugar. Sugar is basically a chemical that has grown in market over last many years. But in this age of changing life styles and people becoming more conscious of their health, the worldwide sugar consumption is going down and is getting replaced by low calorie sweeteners. Many of these Sweeteners are complex chemicals or many times naturals as well.

About Author:
Sandeep Kaur
M.Sc. Microbiology (Hons.) in 2012
Guru Nanak Dev University, Amritsar,
Punjab- 143001.
sandy.flowers305@gmail.com

ABSTRACT:
Medicinal plants are part and parcel of human society to combat diseases from the dawn of civilization. India is sitting on a gold mine of well-recorded and traditionally well practiced knowledge of herbal medicine. India officially recognizes over 3000 plants for their medicinal value and Terminalia plant (Baheda) is one of them. Terminalia species (Family: combretaceace) including Terminalia bellerica, Terminalia arjuna and Terminalia chebula are widely used medicinal plants throughout India and popular in various Indigenous system of medicine like Ayurveda, Sidda and Unani. Terminalia chebula, is called ‘King of Medicine’ in Tibet, because of its extraordinary power of healing. Terminalia plant has been demonstated to possess multiple pharmacological and medicinal activities, such as antioxidant, antimicrobial, antidiabetic, anti-inflammatory, anticancer & tumor and wound healing activity. In the Indian Sytem of Medicine, whole plant including stem bark, fruit, root bark and seeds are used as astringent, cooling, aphrodisiac, cardiotonic, tonic in fractures, ulcers, spermatorrhoea, leucorrhoea, cough, excessive perspiration and skin disorders. Phytoconstituents such as glucoside, tannins, gallic acid, ellagic acid, ethylgalate, gallylglucose and chebulanic acid are mainly believed to be responsible for its wide therapeutic actions. The present review is therefore, an effort to give a detailed survey of the literature on pharmacognosy, phytochemistry and pharamacological activities of the plant1.

About Authors:
Pankaj S. Waghere^1*, Malpani Amol²,
1Prin. K. M. Kundnani College of Pharmacy, Mumbai. Maharashtra, India.
2Roland Institute of Pharmaceutical Sciences, Berhampur. Orissa, India.
*waghere.pankaj@gmail.com

ABSTRACT
Hydrocolloids are naturally-occurring plant polysaccharide, in that gaur gum is most useful and validated natural plant polysaccharide. Guar gum and their derivatives are widely used in pharmaceutical dosage forms. Many are used as biodegradable polymeric materials to deliver active pharmaceutical ingredients. Natural polymers can be modified to obtain tailor-made materials for drug delivery systems and to compete with the synthetic biodegradable excipients available in the market. Natural polymers as a drug carrier material are of two types: polysaccharides and proteins. They found both in plants and animals providing several advantages over synthetic polymers.Gaur gums are preferred to those of synthetic origin due to their green, cost-effectiveness, nontoxic, easy availability and for suitable binder in tablet manufacture. The aim of this review is to provide an insight into the many potential applications of gaur gum as pharmaceutical natural excipients.

About Authors:
NITIN M, MOHAN REDDY U*
Department of Pharmacology,
H.K.E.S’s, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences,
Sedam Road, Gulbarga- 585 105, Karnataka
*mohanreddy.udumula@gmail.com

ABSTRACT
Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately    5-10% of people during their life. The present study was aimed to find out the pharmacodynamic influence of vitamin E and esomeprazole and their combination on gastro intestinal parameters in pylorus ligation induced ulcers in rats in single and multiple dose studies.  Various parameters were studied in  pylorus ligation induced ulcer model viz. gastric volume, pH, total acidity, free acidity, and ulcer index.The antiulcer effect of the combination of vitamin E 0.9 mg/200 g and esomeprazole 0.54 mg/200 g b.w orally was compared with the reference standard esomeprazole 0.54 mg/200 g b.w orally. The ulcer index was calculated and other biochemical parameters of gastric juice were estimated. The ulcer index of combination showed significant (P < 0.05) reduction while other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice showed highly significant (P < 0.001) reduction when compared to control and standard esomeprazole.

About Authors:
Manthan Shah
D.Pharm, B.Pharm, MBA(Marketing & Finance)
Assistant PMT
Sohm India Pvt Ltd
manthanshah.leo@gmail.com

About Authors:
Vishal Sharma^1*, Alankar Shrivastava^2
1Department of Pharmaceutics,
²Senior Lecturer Department of Pharmaceutical Analysis
B.R.NAHATA COLLEGE OF PHARMACY
(A SIRO Recognized by DSIR, Ministry of science & Technology, GOI)
MANDSAUR (M.P.) 458001
*vishus2010@gmail.com

Abstract
Antibiotics are chemical substances, either produced naturally by microorganisms or manufactured synthetically, that are lethal to other microorganisms. Antibiotic resistance (AR) describes the ability of a microorganism to be unaffected by (or resistant to) the effects of a particular antibiotic. A problem arises when a animal or person becomes infected with a disease-causing bacterium that harbors antibiotic resistance to the drug that would be the most suitable treatment for that infection.

India is a vast country of immense diversity.and for that the effectiveness of the antimicrobial was not same to all ,and the administration of them will either really cure or may act in opposite manner and will leads to the development os the antimicrobial resistance which is only due to the unaware use of the antibiotics.we had conducted the survey on some prescriptions of registered medicinal practitioner and find that there was an irrational use of antibiotic in our on community and this might be very serious as our survey is on the smallest level and what it may cause globally.So the use of antibiotic should be controlled.