• PharmaTutor
    1 August 2012

    MONOCLONAL ANTIBODIES : A REVIEW

    About authors:
    1.Shashi Kant*, Satinder Kumar,
    Research scholar department of pharmacy.
    2. Dr. Bharat Prashar
    HOD & Associate professor 
    Department of Pharmaceutical Sciences,
    Manav Bharti University, Solan (H.P)
    shashi_ranaute@yahoo.in

    ABSTRACT :
    In this review article we discussed about are monospecific identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular the non-proprietary drug name ends in mabs,in this we discussed type of monoclonal antibodies,preparation,targeting of monoclonal antibodies as well as advantages and disadvantages of monoclonal antibodies. antibodies that are biology and medicine.

  • 31 July 2012
    REVIEW ARTICLE : ANTIAGING COSMETICS

    About Authors:
    Joshi B.*, Agarwal P., Sahu D., Dashora A.
    Geetanjali Institute of Pharmacy,
    Udaipur Rajasthan, India
    *bhavesh.joshi8@gmail.com

    Abstract:
    Antiaging is emerging class of cosmetics which combine the benefit of anti aging ingredients with the elegance skin feel and delivery system of cosmetics antioxidants, anti cellulites and anti microbial have been use in maintaining and enhancing human beauty. Anti aging ingredients also help to reduce the fine lines, increasing the moisture level and reduces wrinkles and puffness to keep the skin in good condition. New delivery system is a more effective solution for the skin aging resulting from photoaging. New vehicle like liposome and nanoparticles is a new generation for antioxidants with enhanced bioavailability and very stable activity. Our objective is to review present state of the art knowledge pertaining to mechanisms involved in skin aging, factor responsible for aging and various new ingredients use to treat aging defect.

  • 31 July 2012
    EVALUATION OF ANTI-STRESS (ADAPTOGENIC) ACTIVITY OF LUFFA CYLINDRCIA FRUIT EXTRACT

    About Authors:
    Sachin Kaushik*, Dr. shivakumar Hugar
    P.G. Department of Pharmacology,
    B.L.D.E.A.’s college of Pharmacy,
    Bijapur- 586103,
    Karnataka,India
    *sachin_2004_kaushik@yahoo.com

    ABSTRACT:
    In the present study antistress activity was assessed against anoxia tolerance, swimming endurance and cold restraint stress models. In anoxia tolerance test, the mean time of appearing first convulsion in mice was taken as end point to determine the time of anoxia.  In swimming endurance test the mean time of swimming performance was recorded.The end point taken was when the animals remained at the bottom of swimming tank for 10 sec. Biochemical estimation like glucose, cholesterol, triglycerides and BUN and weight of organs were measured in cold restraint stress model.

  • 30 July 2012
    PHARMACODYNAMIC INTERACTION OF FENUGREEK LEAVES EXTRACT WITH FLUVASTATIN IN DIABETES INDUCED VASCULAR DYSFUNCTION

    About Authors:
    ATUL KABRA* , PREMAL KAPADIA
    Department of Pharmacology,
    G.H.B Pharmacy college,
    Aniyad, Gujarat
    * atul.kbr@gmail.com

    ABSTRACT:
    The cardiovascular risk factors were significantly abnormally altered in diabetic rats when compared to normal control. The present study FLEt with low dose of OHA’s indicates the significant improvement in endothelial dependent vasodilatation because the percentage relaxation produced by acetylcholine was more significant when these groups were compared with diabetic control.However all the treated groups restored these changes significantly to normal conditions in diabetic rats when compared to diabetic control. The combined therapy of FLEt and Fluvastatin was found to be significantly effective. Moreover, this combination was also found to demonstrate synergistic behavior than pioglitazone plus fluvastatin.
    We conclude that of preventive therapy with combination of FLEt with OHA’s (low dose) may prevent the endothelial dysfunction in diabetic patients (prediabetic state) due to free radical scavenging activity, metabolic control.

    [adsense:336x280:8701650588]

  • 30 July 2012
    A General Overview On: Dentifrices

    About Authors:
    1Shashi Kant*, Satinder Kumar,
    Research Scholar Department of Pharmacy.
    2Dr. Bharat Prashar
    HOD & Associate professor,
    Department of Pharmaceutical Sciences,
    Manav Bharti University, Solan (H.P)
    * shashi_ranaute@yahoo.in

    Abstract:
    In this general overview, we discussed about dentifrices, types of dentifrices, formulation, evaluation and its recent trends. There have been many dentifrices produced over the years, many focusing on marketing strategies to sell products, such as offering whitening capabilities. The most essential dentifrice recommended by dentists is toothpaste which is used in conjunction with a toothbrush to help remove food debris and dental plaque.

  • 29 July 2012
    FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF ATENOLOL USING SUPER DISINTEGRANT - CROSS POVIDONE AND SWEETENING AGENT - SUCRALOSE

    About Authors:
    Mizna Nigarish*, Vandana Arora Sethi
    Lloyd Institute of Management and Technology
    Plot no.2 knowledge park-2,
    Greater Noida-201306 (U.P)
    *mnigarish2@gmail.com

    ABSTRACT
    The present study has been undertaken to prepare fast dissolving tablets of atenolol by direct compression method with a view to enhance patient compliance. The superdisintegrant used in this study was crosspovidone and sucralose as a sweetening agent. A new formulation of atenolol tablet was designed and compressed by direct compressionmethod. Then its physical parameters including hardness, friability, diameter, thickness, disintegration time, dissolution test were performed for evaluation and characterization of this new formulation. It was observed in the result that the tablet formulation F-4 was found to have maximum drug release at the end of 6 minutes and considered as the most effective formulation. It was also concluded that direct compression technique is a useful method for preparing fast dissolving tablets.

  • 27 July 2012
    TASTE MASKING OF BITTER DRUGS USING DIFFERENT TECHNIQUES FOR BETTER PATIENT COMPLIANCE: AN OVERVIEW

    About Authors:
    MIZNA NIGARISH*, VANDANA ARORA, SAVITA BHATI
    LLYOD INSTITUTE OF MANAGEMENT AND TECHNOLOGY
    PLOT NO.2 KNOWLEDGE PARK-2
    GREATER NOIDA-201306
    (U.P)
    *mnigarish2@gmail.com

    ABSTRACT:
    Taste is an important parameter in administering drugs orally, unwanted or bitter taste is one of the most important formulation problems that are encountered with many drugs and it becomes very necessary for bitter drugs to improve the patient compliance especially in the pediatric and geriatric patients. To overcome with this problem certain taste masking techniques are used in this article, the main aim is to combat with the bitterness using various technologies so as to obtain the desired drug.

  • 27 July 2012
    A REVIEW OF FREE RADICALS AND RHEUMATOID ARTHRITIS

    About Authors:
    Purbajit Chetia*, Manash Pratim Pathak, Prerona Das
    Deptt. of Pharmacology,
    Himalayan Pharmacy Institute, Majhitar,
    Rangpo, E- Sikkim(737132)
    *purbasiv@yahoo.com

    ABSTRACT:
    A free radical is an atom or group of atoms that contains at least one unpaired electron and can easily bond with another atom or molecule, causing a chemical reaction. Free radical is essential for body’s normal physiological functions. But when produced in excess quantities it can causes damage to the cells of the body. Human body generates pro-oxidants in the form of ROS and RNS which are effectively kept in check by the various levels of antioxidant defense. However, when it gets exposed to adverse physicochemical, environmental or pathological agents this delicately maintained balance is shifted in favor of pro-oxidants resulting in ‘oxidative stresses’. It has been implicated in the etiology of several human diseases including Rheumatoid Arthritis (RA) and in the process of ageing.At high concentrations, ROS can be important mediators of damage to cell structures, nucleic acids, lipids and proteins in case of the patients those who are suffering from RA. The hydroxyl radical is known to react with all components of the DNA molecule, damaging both the purine and pyrimidine bases and also the deoxyribose backbone.  Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints and tissue around the joints with infiltration of macrophages and activated T cells. The pathogenesis of this disease is linked predominantly with the formation of free radicals at the site of inflammation. The review is focusing the evidences concerning the involvement of free radicals in Rheumatoid Arthritis and their relationship to specific pathophysiological events.

  • 25 July 2012
    REVIEW ON ANTIBACTERIAL ACTIVITY OF ESSENTIAL OIL OBTAINED FROM SESELI INDICUM

    About Author:
    NITESH.P.SHARMA, AJAY.GUPTA
    IDEAL COLLEGE OF PHARMACY AND RESEARCH, KALYAN
    MUMBAI UNIVERSITY
    Sharmanitesh479@yahoo.com

    ABSTRACT:
    The antibacterial activity of essential oils and their derivatives has been recognized for a long time. In the present study, the antibacterial properties of the essential oils obtained from the seeds of Seseli indicum, of Apiaceae family a wild weed found in the flood prone area of river Tapti, Gorakhpur (India). The essential oil obtained from seed was 3.4%. Essential oils were investigated for activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis using a punched-hole method. Essential oils inhibited all bacteria at both, low and high concentration. The results of this study confirmed the possibility of using Seseli indicum essential oils in broad spectrum antibacterial activities.

    [adsense:336x280:8701650588]

  • 24 July 2012
    EVALUATION OF ANTIULCER ACTIVITY OF FRUIT EXTRACT OF Ziziphus jujuba IN RATS

    About Author:
    ATUL KABRA*, NITIN PATEL
    Department of Pharmacology
    G.H.B Pharmacy college,
    Aniyad, Gujarat
    * atul.kbr@gmail.com

    ABSTRACT:
    The antiulcer effect of aqueous fruit extract of Zizizphus jujuba was studied in ethanol induced ulcer model in rats. The extract dose of 50 mg/kg, 100mg/kg, 200 mg/kgproduced significant inhibition of gastric lesion induced by ethanol. The extarct reduced ulcerative lesion, gastric volume, total acidityin ethanol induced ulcer model.The result obtained suggesting that extract possesses significant antiulcer activity. 

Subscribe to Articles