Formulation and evaluation of herbal ointment for wound healing and anti marking activity by using Vitis venifera and Annona reticulata seeds extracts

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About author:
Gowthami Royal,
Mother Theresa institute, Tirupati

The main aim of the present study was to evaluate the two activities that are anti marking and wound healing activities by Ethanolic extracts of Annona reticulata and Vitis venifera with combination of honey , ghee and neem oil. The both Annona reticulata (custard apple) and Vitis venifera (grapes) are well known plants in Indian traditional medicine. According to the literature reference and Indian traditional use, both Vitus andAnnona were selected for evaluation of wound healing potentiality and anti marking capability. Phyto chemical studies revealed Ethanolic extract of Annona seeds have alkaloids, phytosterol, fixed oil, fats, phenolic compounds, tannins, proteins, amino acids and flavonoids. The studies revealed in case of grape seed extract which is having Linoleic acid, Oleic acid and Palmitic acid. Ethanolic extract of seeds of Annona reticulata and grape seed extract with other ingredients were examined for the activity in the form of ointment in wound models on rat. These formulations for test showed adequate response as compared to standard drug in terms of healing time, marks and tensile growth.

Reference Id: PHARMATUTOR-ART-1349

The plants of genus Annona reticulata belong to the family of Annonaceae is native of west india , eastern and south india as well as the plants of Vitis venifera belong to the family of vitaceae is native of southern German, northern india and Europe. Annona reticulatais a small deciduous or semi-ever green tree in the plant family Annonaceae. It is best known for its fruit, called custard-apple. Plant pacifies vitiated pitta, constipation, burning sensation, anemia, vomiting, cough, malignancy and general tonic. Root decoction is a powerful purgative. Powdered seed kills body and hair lice on external application.

Using the sap of grapevines, European folk healers sought to cure skin and eye diseases. Other historical uses include the leaves  being used to stop bleeding, pain and inflammation of hemorrhoids Unripe grapes were used for treating sore throats, and raisins were given as treatments for consumption (tuberculosis0, constipation and thirst. and . Ripe grapes were used for the treatment of cancer, cholera, smallpox, nausea, skin and eye infections as well as kidney and liver diseases. Seedless grape varieties were developed to appeal to consumers, but researchers are now discovering that many of the healthful properties of grapes may actually come from the seeds themselves, thanks to their enriched phyto chemical content.

Neem oil is generally red as blood, and has a rather strong odor that is said to combine the odors of peanut and garlic. It comprises mainly triglycerides and large amounts of triterpenoid compounds, which are responsible for the bitter taste. Neem oil also contains steroids (campesterol, beta-sitosterol, stigma sterol) and many triterpenoid of which azadirachtin is the most well known and studied. The azadirachtin content of neem oil varies from 300ppm to over 2500ppm depending on the extraction technology and quality of the neem seeds crushed.

Used on the skin, Ghee softens and strengthens, protects and nourishes. It can be applied for broken bones and bruises. It is highly effective for all sorts of skin rashes. It is also used on burns of both fire and chemicals.

honey can be expected to suppress infection in wounds because of its high sugar content, but dressings of sugar on a wound have to be changed more frequently than honey dressings do to maintain an osmolarity that is inhibitory to bacteria, as honey has additional antibacterial components. Since microbiological studies have shown more than one hundred-fold differences in the potency of the antibacterial activity of various honeys, best results would be expected if a honey with a high level of antibacterial activity were used in the management of infected wounds.

Wound: it is a physical trauma where the skin is torn, cut or punctured. Whenever it exposed to air, micro organisms are entered the wound, which leads to infection.
Mark: marks are black mole like structures formed after healing of wound nd stay at the site very long time.



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