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  • 10 September 2012

    ARTHRITIS IS THE NAME GIVEN FOR PAINFUL JOINT DISEASES

    About Author:
    Kapil Sharma
    Yaresun Pharmaceutical Pvt. Ltd., India.
    pharma_kapil@rediffmail.com

    Introduction:
    Arthritis is the name given for painful joint diseases. Arthritis one of the most common health problems in india. Arthritis also is the leading cause of disability. Rheumatoid arthritis (RA) is a chronicinflammatory condition of the connective tissues throughout the body, but especially around the joints. The main sign of RA is often stiff, painful, and swollen joints.  Areas of typical complaint include the hands, feet, wrists, ankles, and knees.  Depending on the severity of the condition, these areas may eventually become deformed. The exact cause of rheumatoid arthritis remains, largely, unknown.  It has been theorized that a number of genetic and environmental factors may contribute to the disease process, and may include genetics, poor nutrition, lifestyle, chronic stress in rheumatoid arthritis, the joint lining, or synovial membrane, becomes inflamed and the joints become stiff and swollen. The synovial membrane secretes a slippery fluid that covers the cartilage-covered joints and reduces the friction between adjacent joints.The chronic inflammation of rheumatoid arthritis eventually leads to destruction of the cartilage covering the ends of the joints and underlying bone.  In many cases this damage causes joint deformity.

  • 9 September 2012
    BIMETALLIC NANOPARTICLES –A REVIEW ON THEIR PREPARATION AND CHARACTERIZATION

    About Authors:
    T.V.Thulasiramaraju*, A.Arunachalam, G.V.SurendraBabu
    A.M.Reddy Memorial College Of Pharmacy,
    Narasaraopet, Andhrapradesh, Pin-522601.
    *Thulasiramaraju912@gmail.com

    ABSTRACT:
    Nanoparticles (these are materials of which at least one dimension is nanometric, i.e. 10-9 m) consist of several tens or hundreds of atoms or molecules and may have a variety of sizes and morphologies (amorphous, crystalline, spherical, needles, etc.).Such nanoparticles are creating a new category of materials, which is different either from conventional bulk materials or from atoms, the smallest units of matter. Nanoscale materials are used in electronic, magnetic and optoelectronic, biomedical, pharmaceutical, cosmetic, energy, catalytic and materials applications. This review was focused on bimetallic nanoparticles their structure, preparation and characterization.

  • 9 September 2012
    INVOLVEMENT OF HEALTHCARE REGULATORY AFFAIR PROFESSIONAL IN OVERSEAS REGISTRATION PROCESS

    About Authors:
    ANUJ SINGH
    VINAYAKA MISSION’S UNIVERSITY
    Salem – 636308, Tamil Nadu
    anuj.dra@gmail.com

    ABSTRACT:-
    Healthcare Regulatory Affair Professional with their experience and strong motivation to excel in the Regulatory field has an ability to motivate & give support and strengthen to teams members, involved in process of product registration. Professional has taught a self-starter with the proven ability to prioritize and manage projects in a busy, fast-paced, multitasking environment, along with their experience in establishing relationship with the decision makers & coordinator. The Pharmaceutical industries are among the most highly regulated industries in the country. As India is growing very rapidly in pharmaceutical sector, there is a need of regulatory affairs professionals to cater the current needs of industries for the global competition. Regulatory affairs professionals are the link between pharmaceutical industries and worldwide regulatory agencies. They are required to be well versed in the laws, regulations, guidelines and guidance of the regulatory agencies. There is a growing need to incorporate the current requirements of pharmaceutical industries in the standard curriculum of pharmacy colleges to prepare the students with the latest developments to serve the industries. The present article discusses the regulatory education and its need, learning resources, courses available, syllabus contents and job opportunities in regulatory affairs.

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  • 7 September 2012
    TRANSDERMAL GEL OF MICONAZOLE NITRATE

    About Authors:
    DHIRAJ YADAV
    BABU BANARASI DAS UNIVERSITY,
    LUCKNOW
    dhirajyadav06@gmail.com

    ABSTRACT
    Miconazole is the antifungal drug, has been used in the treatment of fungal infection of skin and also in yeast infection. In order to decrease the skin rashes, skin irritation, and also for best effect on the skin, miconagol gels have been developed. This study was conducted to develop a gel formulation of miconazole using four types of gelling agents: carbopol, carboxymethylcellulose sodium (Na CMC) and sodium alginate. Effect of penetration enhancer (propylene glycol) on the release has been studied. The gels were evaluated for physical appearance, rheological behaviour, drug release and stability. The drug release from all gelling agents through a standard cellophane membrane was evaluated using Keshary-Chien diffusion cell. All batches of gels showed acceptable physical properties concerning colour, homogeneity, consistency, spreadability and pH value.
    Among all the gel formulations, carbopol showed superior drug release than followed by Na CMC, and sodium alginate. Drug release decreased with increase in polymer concentration. Drug release was not linearly proportional with the concentration of penetration enhancer or co-solvents. Stability studies showed that the physical appearance, rheological properties, and drug release remained unchanged upon storage for two months at ambient condition.

  • 6 September 2012
    ALOES SPECIES- A COMPREHENSIVE REVIEW

    About Authors:
    Krishn Kumar Agrawal*, Kishan Singh, Bhupesh Chander Semwal
    Institute of Pharmaceutical Research GLA University,
    Mathura-281403 (U.P.) India.
    *Krishn.agrawal@rediffmail.com

    ABSTRACT:
    Medicinal plants have been a major source of therapeutic agents since ancient times to cure human disease. Aloes species (family-Liliaceae) is a widely used herbaceous, shrubby, arborescent, perennial or xerophytic succulents medicinal plant cultivated throughout India and popular in various indigenous system of medicine like Ayurveda, Siddha, Unani and Tibb. Traditionally the juice of aloe is used as bitter, laxative, purgative and cathartic. They are also useful in jaundice, dyspepsia, piles, skin disease, abotificient, trophic ulcer, wounds healing and many more ailments. The present review is therefore, an effort to give a detailed survey of the literature on pharmacognosy, phytochemistry and pharmacological activities of the plant.

  • 6 September 2012
    PHARMACOLOGICAL ACTIVITY OF AMARANTHUS SPINOSUS WITH SPECIAL REFERENCE TO ITS ANTIPYRETIC ACTIVITY

    About Authors:
    SAMRAT BOSE*, SUCHARITA ROY
    Department of Pharmacology
    Bengal School of Technology,
    Chuchura, West Bengal.
    *samratbose09@gmail.com

    ABSTRACT:
    Amaranthus spinosus, commonly known as the spiny amaranth, prickly amaranth or thorny amaranth, belonging to family Amaranthaceae. Tradionally A.spinosus used as diuretic, anti-diabetic, antipyretic, anti-snake venom, anti-leprotic and anti-gonorrheal, anti helmintic, anti androgenic etc[1]. The aim of present study was to investigate the antipyretic activity of MeOH-Water extract of Amaranthus spinosus in rats. MeOH-Water extract was administered at a dose of 100mg/kg, 400mg/kg and 600mg/kg through ip.

  • 6 September 2012
    A REVIEW ARICLE ON SYNTHESIS AND BIOLOGICAL PROPERTY OF SOME NOVEL BUTENOLIDE DERIVATIVES

    About Authors:
    Rajender Kumar1*,Dr.Sukhbir L.Khokara2,
    1Department of Pharmacy, Manav Bharti University, Solan (H.P.) 173229
    2Institute of pharmaceutical sciences, Kurukshetra University,
    Kurukshetra, Harayana-136119
    *rajkaushal13@gmail.com

    ABSTRACT
    Butenolides (furanones) consist of unsaturated γ- lactone which occur in plants as glycosides. There is a group of steroids which contain α,β unsaturated butenolide ring in the side chain such steroids are known as cardenolides. The  presence of γ - lactone ring contain natural products like Goniobutenolides A & B ,Digitoxigenin and  lignans. These compound have biological properties like antibiotic, antitumor, anticonvulsant, antimicrobial and medicinal uses like fungicides, bactericides and allergic inhibitor.

  • 6 September 2012
    PRELIMINARY PHYTOCHEMICAL AND IN-VITRO ANTHELMINTIC SCREENING OF HIBISCUS ROSA-SINENSIS LINN. FLOWER EXTRACTS (FAMILY: MALVACEAE)

    About Author:
    Krishn Kumar Agrawal*, Jeetendra Kumar Gupta, Anju Verma, Kishan Singh
    Institute of Pharmaceutical Research,
    GLA University 17-Km. stone, NH-2 Mathura-Delhi Highway,
    P.O. Chaumuhan, Mathura-281406 (U.P.) India
    *krishn.agrawal@rediffmail.com

    Abstract
    The objective of the present study to investigate the anthelmintic activity of aqueous and ethanolic extract of flower of Hibiscus rosa-sinensis L. (family: Malvaceae) against Indian earthworms (Pheretima posthuma). The preliminary phytochemical screening of Hibiscus rosa-sinensis showed the presence of sterols, glycosides, alkaloids, proteins, mucilage and flavonoids. Various standards such as Piperazine citrate, Albendazole and Pyrantel pamoate at concentration of 20mg/ml were used to compare anthelmintic activity with the extracts at the same concentration in terms of paralysis time and death time of worms. The result revealed the potential usefulness of aqueous and ethanolic extract of Hibiscus rosa-sinensis flower against helminthiasis infection.

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  • 4 September 2012
    PHYTOSOMES: AN EMERGING TECHNOLOGY FOR IMPROVING PHYTOCHEMICAL BIOAVAILABILITY- A REVIEW

    About Author:
    Ramandeep Kaur
    Assistant Professor, CT Institute of Pharmaceutical Sciences,
    Jallandhar- 143001
    deepraman_18@yahoo.in

    ABSTRACT
    Phytosomes are little cell like structure which are also termed herbosomes which are formed by complexation of the polyphenolic phytoconstituents in molar ratio with phosphatidylcholine. Bioavailability of flavonoid containing phytomedicines, is reported to be low and erratic due to limited absorption, elevated presystemic metabolism and rapid elimination. But their phytosomal formulations show improved absorption, enhanced delivery and increased bioavailability of phytochemicals than the conventional herbal extracts containing dosage forms. Phytosome technology has been effectively used to enhance the bioavailability of many popular herbal extracts e.g. milk thistle, grape seed, green tea, hawthorn, etc. The improved pharmacokinetic and pharmacological properties of phytosomes make them suitable for the treatment of serious degenerative disorders. This article reviews the recent trends and applications of various herbal extract phytosomes as a tool of drug delivery system and as an emerging technology for increasing bioavailabity of phytoconstituents.

  • 4 September 2012
    GC-MS ANALYSIS OF ACALYPHA INDICA LINN

    About Author:
    Manisha Singh
    Sagar Institute of Pharmacy & Technology,
    Gandhi nagar, Bhopal (M.P.)
    manishamasih85@gmail.com

    Abstract
    Acalypha indica Linn. consists of dried herb of Acalypha indica Linn. belonging to familyEuphorbiaceae. Within the Euphorbiaceae family, Acalypha indica is one of the biggest and most diverse, with nearly 450 species. Two thirds of its species are found in America, 19 of them in Venezuala, they are mainly used as ornamental, but with the rising of traditional medicine, these species are given medical properties painkillers, laxatives, anti-inflammatory and many others.The GC-MS analysis of methanol and acetone (70 : 30) extract prepared from the whole plant of Acalypha indica linn. revealed the presence of different phytochemicals.

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