December 2012

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support.

The PGIMER owes its inception to the vision of late Sardar Partap Singh Kairon, the then Chief Minister of Punjab and the distinguished medical educationists of the then combined state of Punjab, supported by the first Prime Minister of India Pt. Jawahar Lal Nehru who considered the institutions of scientific knowledge as temples of learning and the places of pilgrimage.

A reputed & professionally managed Pharma company with National & International presence requires professionals under its expansion plan.

Post: Zonal Sales Manager, Area Sales Manager, Territory Managers, Hospital Executives

[adsense:336x280:8701650588]

About Authors:
Vijaya Kumar.Voleti*¹, Vaishnavi.V², V.Gunasekharan¹, M.S.Riyazullah¹, K.Vivekanandan^1
1Department of pharmaceutics, Rao’s College of Pharmacy, Nellore, Andhra Pradesh, India,
²Department of pharmaceutics, Sankar Reddy Institute of Pharmaceutical Sciences, Andhra Pradesh, India
*vijay66vvk@gmail.com

ABSTRACT:
Colon specific drug delivery has gained a more importance for the delivery at colonic region by use of various drugs to treat the both local and systemic diseases. Local diseases include Chron’s disease, ulcerative colitis, and colorectal cancer. Other serious disorders like nocturnal asthma, Hyper tension , arthritis and angina can also be cured by these techniques. Colonic delivery is a good candidature for delivery of proteins peptides and vaccines where the enzymatic degradation and the hydrolysis of proteins can be minimized and increases the systemic bioavailability. A drug should be protected from the absorption and the upper GI environment to achieve the successful colonic drug delivery. The colon specific delivery of drugs to the target receptor sites has the advantage to reduce the side effects and improves the therapeutic response. Colon specific drug delivery are being developed by taking advantage of the luminal PH conditions and the presence of microbial enzymes such as azoreductase, pectinase, dextranase…etc. This review mainly reveals on the various concepts and approaches include Prodrug, PH and time dependent systems and microbially triggered systems used in the development of colon specific drug delivery. This also focuses on the novel approaches namely Pressure controlled colonic delivery, osmotic controlled drug delivery and CODESTM. Invitro and in vivo evaluation parameters has been discussed here.

About Authors:
Soniya^1*, Tarun Parashar¹, Satyanand Tyagi², Patel Chirag J³, Rishikesh Gupta^4
1*Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248002.
²President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
⁴Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
*soniyarani487@gmail.com 08006939832/09999261031

ABSTRACT:
To obviate the problems associated with conventional dosage forms, mouth dissolving tablets have been developed having good hardness, dose uniformity, easy administration, faster disintegration without water and serves as the first choice of dosage form for pediatrics, geriatrics and traveling patients. Mouth dissolving tablets (MDTs) are also known as fast melting tablets, fast disintegrating tablets, fast dissolving/dispersing tablets or melt in mouth tablets.This article gives a brief review of mechanism of action, technologies used now a day for MDTs,Some of promising drug candidates for MDT and evaluation parameters MDTs.Due to wide significance of MDT, this drug delivery system may lead to better patient compliance and ultimate clinical output.

About Authors:
Arshad Hala*, Prof. Rajesh Dholpuria, Nilesh sovasia
Seth G. L. Bihani S. D. College Of Technical Education,
Institute Of Pharmaceutical Sciences & Drug Research,
Gaganpath, Sri Ganganagar, Rajasthan 335001
*Arshad_hala@yahoo.com

ABSTRACT:
Over the past fifty years nuclear magnetic resonance spectroscopy, commonly referred to as NMR, has become the preeminent technique for determining the structure of organic compounds. Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and research for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. Once the basic structure is known, NMR can be used to determine molecular conformation in solution as well as studying physical properties at the molecular level such as conformational exchange, phase changes, solubility, and diffusion.Of all the spectroscopic methods, it is the only one for which a complete analysis and interpretation of the entire spectrum is normally expected. Although larger amounts of sample are needed than for mass spectroscopy, NMR is non-destructive, and with modern instruments good data may be obtained from samples weighing less than a milligram. To be successful in using NMR as an analytical tool, it is necessary to understand the physical principles on which the methods are based.

IIT Bombay, set up by an Act of Parliament, was established in 1958, at Powai, a northern suburb of Mumbai. Today the Institute is recognised as one of the centres of academic excellence in the country.