Articles

ABOUT AUTHORS:
Vishwanadham Yerragunta*¹, Duggi.Suman¹, Kumara swamy¹, V.Anusha¹, Pratima Patil¹, M. Naresh²
Department of Pharmaceutical Chemistry,
¹Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad-500014, A.P.
²Bharath Institute of Technology Pharmacy-Ibrahimpatnam, AP.
*vishwanadham.y@gmail.com
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ABSTRACT:
The aim of this review is to provide an overview of diverse pharmacological activities of pyrazole moiety. Pyrazole are well known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. Pyrazole chemically known as 1, 2-diazole has become a popular topic due to its manifold uses. Numerous pyrazole derivatives have been found to possess a broad spectrum of biological activities, which stimulated the research activity in this field. Pyrazoles and its derivatives represent one of the most active classes of compounds, which possess wide range of biological activities like anti-bacterial, anti-convulsant, analgesic, anti-microbial, anti-inflammatory, ant diabetic, sedative anti-rheumatic, anticancer, and anti-tubercular activities. The purpose of this review was to collate literature work reported by researchers on pyrazole for their various pharmacological activities and also reported recent efforts made on this moiety.

About Authors:
Umakant Sahu^1,2, Nrusingha Charan Panda², B.V.V Ravikumar², Anjan Kumar^2
1Drugs testing laboratory avam anusandhan Kendra, First Floor, Govt. Ayurvedic College Hospital Building, Ayurvedic College Campus, G.E. Road Raipur, Chhattisgarh- 492010

About Authors:
*¹Ronak Patel, ²Mr. Ripal Mistry
¹M.Pharm, Bhupal Nobels’ College Of Pharmacy, Udaipur 313001
²M.pharm, Indubhai Patel College Of Phaarmacy And Research Center, Dharmaj
*rk4989@gmail.com

Let us first of all know about plagiarism and how it is different from copyright piracy. Plagiarism word is derived from Latin word plagiaries which mean stealing someone else’s work¹. According to oxford dictionaries its literal meaning is “the practice of taking someone else’s work or ideas and passing them off as one’s own”². Wikipedia defines plagiarism as “the wrongful appropriation and purloining and publication of another author's language, thoughts, ideas, or expressions, and the representation of them as one's own original work”¹. The word plagiarism is different from copyright piracy³. Copyright piracy is unauthorised doing anything, the exclusive right to do which is with copyright owner or reproduction, sale or hiring in any form^4,5 whereas plagiarism is the failure of giving credit to original author⁵ but both are infringements of copyright (under Indian Copyright Act, 1957) and hence crime. Unauthorised reproduction, sale or hiring is not infringement of copyright after expiry of the copyright protection period which varies nation-wise (minimum requirement under Berne Convention is 50 years and 60 years in case of India, post mortem of copyright owner) but under author’s moral rights his authorship and control over the work is forever and no one can represent it as his/her own original work⁶. If someone is doing so it would be plagiarism and hence serious ethical offense and crime.

About Authors:
Prof. (Dr.) N.V.Satheesh madhav, Rohit Singh Negi, *Vikash kumar
DIT-Faculty of Pharmacy,
Dehradun Institute of Technology,
Mussoorie Diversion Road,
Makkawala, P.O. Bhagwantpur,
Dehradun, Uttrakhand
*vikashmalik81@gmail.com, satheesh_madhav@yahoo.com
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Abstract:
The aim of research work was to isolate novel biopolymer from the seeds of Tagetes erecta and to characterize its physicochemical properties along with the acute toxicity. The isolated polymer was subjected for screening its retard ability by using as a bio nano carrier for formulating Doxycycline (model drug) loaded floating films. Tagetes is a genus of 56 species of annual and perennial mostly herbaceous plants in the sunflower family. The genus is native to North and South America, but some species have become naturalized around the world. Tagetes species vary in size from 0.01 to 2.2m tall. They have pinnate green leaves blooms are naturally in golden, orange, yellow and white colors, often with maroon highlights. Tagetes grow well in almost any sort of soil. It contains essentials oils, fatty acids, carotenoids and lutein. Tagetes erecta has long been known for its medicinal use, especially for strengthening the heart, and for treating ailments like headaches, swellings and tooth aches.  Tagetes erecta seeds were soaked in water and then washed with chloroform and ethyl acetate. Obtained 100 gm of fine powder was soaked in 100ml boiled water for 24 hours. The mixture was filtered and methanol was added in double. The solution was refrigerated for 24 hours and then centrifuged. Precipitate was collected as biopolymer and was dried. The separated biopolymer was subjected for various physicochemical parameters like color, texture, particle size, solubility, colour changing point. Spectral analysis such as IRspectroscopy was done to check the polymeric nature of biopolymers. Drug–polymer interaction and skin irritancy studies are also done to check the polymer safety.

ABOUT AUTHORS:
Vishwanadham Yerragunta*, Prathima Patil, V.Anusha, T.Kumara Swamy, D.Suman, T.Samhitha.
Department of Pharmaceutical Chemistry,
Malla Reddy College of Pharmacy,
Maisammaguda, secunderabad-14. A.P.
Vishwanadham.y@gmail.com
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ABSTRACT:
Pyrimidine is a heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3 of the six- member ring shows wide range of biological activities. Pyrimidine posses wide spectrum of biological activities like including anti-tubercular, anti-bacterial, anti-fungal, anti-viral, anti-inflammatory, Anti-malarial activity, anti-cancer and anti-neoplastic activity, anti-hiv activity. The present reviews attempted to gather the various biological activities of pyrimidine derivatives and is marketed drugs.

ABOUT AUTHORS:
Dr. D. Nagendrakumar, Reddy VM, Keshavshetti G G, Shardor A G*
Department of Pharmaceutics, SVET’s College of Pharmacy,
Humnabad- 585 330 (Karnataka).
ambarish.pharma@gmail.com
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ABSTRACT
Sustained release matrix system are favored because of their simplicity, patient compliance etc, than traditional drug delivery which have many drawbacks like repeated administration, fluctuation in blood concentration level etc. For the purpose of enhancement the bioavailability of furosemide, a dosage form with sustained release of furosemide was designed in this study.
Sustained release tablets of furosemide were fabricated using xanthan gum(13.33 % to 66.67 %). Thepreparedtablets were evaluated for pre compression and post compression studies likeangle of repose, bulk density, tapped density, hardness, weight variation, fraibilty, drug content, in-vitro releaseof drugetc. among the five formulations A better controlled drug release (85 %) was obtained with the matrix tablet SX₅ containingxanthan gum66.67%. Short-term stability studies of all formulations indicates that there were no significant changes in drug content and dissolution parameter values after 3 month storage at 40° ± 2°C/75 ± 5% RH.

About Authors:
Venkata Anil Kumar Sistla*, Dr.P.Venkateshwara Rao, P.Rajavel
Department of Pharmaceutical Analysis
A.M.Reddy Memorial College of Pharmacy,
Narasaraopeta - 522601,
Guntur Dt, India.
*anilkumar5831@gmail.com
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