Vol-1-Issue-2

FORMULATION OF DOXYCYCLINE LOADED FLOATING FILM USING BIO-MATERIAL EXTRACTED FROM TAGETES erecta

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About Authors:
Prof. (Dr.) N.V.Satheesh madhav, Rohit Singh Negi, *Vikash kumar
DIT-Faculty of Pharmacy,
Dehradun Institute of Technology,
Mussoorie Diversion Road,
Makkawala, P.O. Bhagwantpur,
Dehradun, Uttrakhand
*vikashmalik81@gmail.com, satheesh_madhav@yahoo.com

Abstract:
The aim of research work was to isolate novel biopolymer from the seeds of Tagetes erecta and to characterize its physicochemical properties along with the acute toxicity. The isolated polymer was subjected for screening its retard ability by using as a bio nano carrier for formulating Doxycycline (model drug) loaded floating films. Tagetes is a genus of 56 species of annual and perennial mostly herbaceous plants in the sunflower family. The genus is native to North and South America, but some species have become naturalized around the world. Tagetes species vary in size from 0.01 to 2.2m tall. They have pinnate green leaves blooms are naturally in golden, orange, yellow and white colors, often with maroon highlights. Tagetes grow well in almost any sort of soil. It contains essentials oils, fatty acids, carotenoids and lutein. Tagetes erecta has long been known for its medicinal use, especially for strengthening the heart, and for treating ailments like headaches, swellings and tooth aches.  Tagetes erecta seeds were soaked in water and then washed with chloroform and ethyl acetate. Obtained 100 gm of fine powder was soaked in 100ml boiled water for 24 hours. The mixture was filtered and methanol was added in double. The solution was refrigerated for 24 hours and then centrifuged. Precipitate was collected as biopolymer and was dried. The separated biopolymer was subjected for various physicochemical parameters like color, texture, particle size, solubility, colour changing point. Spectral analysis such as IRspectroscopy was done to check the polymeric nature of biopolymers. Drug–polymer interaction and skin irritancy studies are also done to check the polymer safety.

PYRIMIDINE AND ITS BIOLOGICAL ACTIVITY: A REVIEW

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ABOUT AUTHORS:
Vishwanadham Yerragunta*, Prathima Patil, V.Anusha, T.Kumara Swamy, D.Suman, T.Samhitha.
Department of Pharmaceutical Chemistry,
Malla Reddy College of Pharmacy,
Maisammaguda, secunderabad-14. A.P.
Vishwanadham.y@gmail.com

ABSTRACT:
Pyrimidine is a heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3 of the six- member ring shows wide range of biological activities. Pyrimidine posses wide spectrum of biological activities like including anti-tubercular, anti-bacterial, anti-fungal, anti-viral, anti-inflammatory, Anti-malarial activity, anti-cancer and anti-neoplastic activity, anti-hiv activity. The present reviews attempted to gather the various biological activities of pyrimidine derivatives and is marketed drugs.

DESIGN AND DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLETS OF FUROSEMIDE

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ABOUT AUTHORS:
Dr. D. Nagendrakumar, Reddy VM, Keshavshetti G G, Shardor A G*
Department of Pharmaceutics, SVET’s College of Pharmacy,
Humnabad- 585 330 (Karnataka).
ambarish.pharma@gmail.com

ABSTRACT
Sustained release matrix system are favored because of their simplicity, patient compliance etc, than traditional drug delivery which have many drawbacks like repeated administration, fluctuation in blood concentration level etc. For the purpose of enhancement the bioavailability of furosemide, a dosage form with sustained release of furosemide was designed in this study.
Sustained release tablets of furosemide were fabricated using xanthan gum(13.33 % to 66.67 %). Thepreparedtablets were evaluated for pre compression and post compression studies likeangle of repose, bulk density, tapped density, hardness, weight variation, fraibilty, drug content, in-vitro releaseof drugetc. among the five formulations A better controlled drug release (85 %) was obtained with the matrix tablet SX5 containingxanthan gum66.67%. Short-term stability studies of all formulations indicates that there were no significant changes in drug content and dissolution parameter values after 3 month storage at 40° ± 2°C/75 ± 5% RH.

A REVIEW ON CHALCONES AND ITS IMPORTANCE

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About Authors:
Vishwanadham Yerragunta*, T.Kumara swamy, D.Suman, V.Anusha, Prathima Patil, T. Samhitha
Department of Pharmaceutical Chemistry,
Vishnu Institute of Pharmaceutical Education and Research,
Narsapur, Medak – 502313, A.P.
Vishwanadham.y@gmail.com

Abstract:
Chalcones are precursor compounds for flavonoids biosynthesis in plants, and they can also be synthesized in laboratory. Chalcones possess a broad spectrum of biological activities including antioxidative, antibacterial, antihelmintic, amoebicidal, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, cytotoxic and immunosuppressive. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity and good pharmacological actions. Chalcones became an object of continued interest in both academia and industry. Nowadays, several chalcones are used for treatment of viral disorders, cardiovascular diseases, parasitic infections, pain, gastritis, and stomach cancer, as well as like food additives and cosmetic formulation ingredients. However, much of the pharmacological potential of chalcones is still not utilized. The purpose of this review is to describe the recent efforts of scientists in pharmacological screening of synthetic chalcones, studying importance of chalcones, and synthesis of pharmacologically active chalcones and their biological activities.

METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND EPERISONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORMS

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About Authors:
Venkata Anil Kumar Sistla*, Dr.P.Venkateshwara Rao, P.Rajavel
Department of Pharmaceutical Analysis
A.M.Reddy Memorial College of Pharmacy,
Narasaraopeta - 522601,
Guntur Dt, India.
*anilkumar5831@gmail.com

Abstract
A simple, selective, rapid, precise and economical reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of Paracetamol and Eperisone Hydrochloride in pharmaceutical Tablet dosage form. The mobile phase consisted of 60:40 % (v/v) of Methanol & 0.1% v/v orthophosphoric acid operated on isocratic mode. The flow rate is 1.0 ml/min. Chromatographic separation of Paracetamol and Eperisone Hydrochloride was performed on PHENOMENEX C18 column (150 X 4.6 cm, ODS, 5µm). The wavelength of detection is 270 nm. The injection volume is 20µL. The retention time of Paracetamol and Eperisone Hydrochloride are 2.21 ± 0.10 minutes and 2.74 ± 0.10 respectively. The run time of analysis is 6 minutes. The developed method was validated for parameters such as accuracy, precision, linearity, limit of detection, limit of quantitation. The influence of acid, alkaline, oxidative Stress and photolytic stress conditions on both the drugs was studied. Results indicated partial degradation in alkaline medium for Paracetamol and Eperisone Hydrochloride. The proposed method has been successfully used for the estimation in tablet dosage forms.

SUCCESS STORIES OF ENOLATE FORM OF DRUGS

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About Authors:
Arvind Negi1*, Balraj Singh Gill2
1Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda- 151001
2Centre for Biosciences, Central University of Punjab, Bathinda-151001
*arvindnegi2301@gmail.com

Abstract
Stereochemistry of clinical agents play a key role in their success to become drugs. Tautomerism is a structural isomerism, playing a key role in the orientation of organic compounds and also found significant in distinctive base pairing in nucleic acids. Keto-enol form usually occurs and found prominently among different types of tautomers. The enol form ionizes in the physiological solution into enolate and alter the biological activity. So, how this enolate form brings modification in pharmacokinetics and pharmacodynamics of a drug is very important and quite interesting to know. As this form is ionic in nature so it increases the interaction with the concerning receptors, enzymes, ion channels or functional proteins. In this review we cover and compile success, role and the significance of the enolate form of clinical agents which succeed to become drugs!

ANAPHYLACTIC SHOCK: SHOCKING ERROR OF IMMUNE SYSTEM!

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About Author:
Arvind Negi
Centre for Chemical and Pharmaceutical Sciences
Central University of Punjab, Bathinda-151001
arvindnegi2301@gmail.com

Abstract
Activation of immune response is developed in respect to some xenobiotic sensitization, which is supposed to prevent and protect the body from sufferings induced by these xenobiotic. But unfortunately sometime body behaves in a paradoxical manner which misguides the immune system and ultimately turned into a bizarre situation of immune function. One of such response is anaphylactic shock, which is quite fatal if untreated. This review brings insights into the molecular physiology of anaphylactic shock and how some people elicit allergic response to certain substances but not the other. This major catastrophe of the body holds an error of immune system whereas this commentary based review disclosed the synchronization of the unfortunate lessons of the immune system, which makes it a cruel to cause DEATH!

ENHANCEMENT OF SOLUBILITY; AN OVERVIEW

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ABOUT AUTHORS:
Ramesh Babu Pedada1*, Eukondalu Vanka1, Dr.A.M.S.Sudhakar Babu1, Prasanna kumar Desu1, P.Ramaa Bharathi1, P.Venkateawara.rao2
1Department of Pharmaceutics, 2Department of Pharmaceutical  Analysis,
A.M.Reddy Memorial College of pharmacy, Narasaraopet, Guntur (Dt), Andhra Pradesh, India.
Rameshbabu.pedada@gmail.com

ABSTRACT:
Enhancement of solubility, dissolution rate and bioavailability of drug is a very challenging task in drug development, nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs. Aqueous solubility of any therapeutically active substance is a key property as it governs dissolution, absorption and thus the in vivo efficacy. Orally administered drugs completely absorb only when they show fair solubility in gastric medium and such drugs shows good bioavailability. The solubility and dissolution properties of drugs play an important role in the process of formulation development. Problem of solubility is a major challenge for formulation scientist which can be solved by different technological approaches during the pharmaceutical product development work. The present review deals in detail about the solubilisation by surfactants, cosolvents, complexation for the improvement of solubility of poorly water soluble drugs.

THYROID DYSFUNCTIONS AND ITS MONITORING

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About Authors:
Pathak Namita*, Kothiyal Preeti, Dr. Prashant Mathur
Department of Clinical Pharmacy,
Shri Guru Ram Rai Institute of Technology and Sciences,
Dehradun, Uttarakhand, India, 248001
pathak_namita@ymail.com

Abstract
The prevalence of hypothyroidism is three times higher among women than men. The prevalence in an unselect­ed community population of young, middle aged and elderly individuals is about 1.4 percent and the estimated annual incidence rate is one to two per 1,000 women. Surveys of geriatric populations have yielded estimated prevalence rates for overt hypothyroidism of 0.2 percent to 3 percent. The presentation of symptoms in the elderly may be atypical or absent. The prevalence of subclinical hypothyroidism is estimated to be between 4.0–8.5% of the adult US population without known thyroid disease, and the prevalence increases with age. Up to 20% of women over the age of 60 are estimated to have subclinical hypothyroidism. Caucasians are more likely to have subclinical hypothyroidism than non-Caucasians. The risk is highest in those with type I diabetes mellitus, a family history of thyroid disease or head/neck cancers treated with external beam radiation. Other risk factors include previous radioactive iodine treatment or thyroid surgery. Interestingly, about 20% of patients on thyroid medications are both over re­placed and under replaced. Because of the high incidence of thyroid disease, The American Thyroid Association recommends measuring thyroid function on all adults beginning at age 35 years and every 5 years thereafter noting that more frequent screening may be appropriate in high risk groups. The treatment of subclinical hypothyroidism has been controversial but more recent data suggest there are increased risks of ischemic heart disease in untreated patients and that a more aggressive approach to treat­ ment would be appropriate.7 In contrast, subclinical hyperthyroidism has more well understood risks of atrial fibrillation and flutter and so should be more ag­gressively treated.

FORMULATION, DEVELOPMENT AND OPTIMIZATION OF FAST DISPERSIBLE ORAL FILMS OF DOMPERIDONE MALEATE

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ABOUT AUTHORS:
Krupa Mehta, Nitu Changoiwala, Sanjay C. Modi, Dr. Mukesh C. Gohel, Dr. Rajesh K. Parikh
L. M. College of Pharmacy, Navrangpura,
Ahmedabad, Gujarat-380009, India

ABSTRACT:
Objective:
To Formulate, Develop and Optimize fast dispersible oral films of Domperidone maleate.
Materials and Methods:
Fast dispersible films of Domperidone maleate were prepared using solvent casting method. Films were formulated using Hydroxy Propyl Methyl Cellulose (HPMC-E5) as a film forming agent, PEG-400 as a plasticizer. A 32 full factorial design was applied systematically to optimize the drug release and folding endurance. The concentration of HPMC-E5 (X1) and concentration of PEG-400 (X2) were selected as independent variables.
  The Percentage Drug Release in 5 minutes (Y1) and Folding endurance (Y2) were selected as dependent variables. The prepared films were evaluated for Thickness, Folding endurance, Tensile Strength, Disintegration time, In vitro drug release and Drug content uniformity.  DSC studies were conducted for drug-excipient interactions.
Results: Films prepared were found to be of good quality fulfilling all the requirements. Regression analysis and numerical optimization were performed to identify the best formulation. Formulations F10 prepared with 2.7% HPMC-E5 and 20% PEG-400 was found to be the best formulation with 96% Drug release in 5 minutes and folding endurance 24.
Discussion: X1 and X2 significantly affected the Percentage Drug Release in 5 minutes (Y1) and Folding endurance (Y2). Percentage Drug Release decreased as the concentration of HPMC-E5 and PEG-400 increased. Folding endurance increased as the concentration of HPMC-E5 and PEG-400 increased.
Conclusions: Fast dispersible films of Domperidone maleate were successfully formulated by Solvent casting technique with immediate onset of action & improved patient compliance.

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