SGRRITS

Protein-protein surface interactions: Constrains of homologous versus heterogeneous domains

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ABOUT AUHTOR
Nitisha Bhandari*, Akanksha Bhandari
Shri Guru Ram Rai Institute of Technology and Science, Patel Nagar,
Dehradun 2Graphic Era University, Dehradun, India
*nitishabhandari89@gmail.com

ABSTRACT
Interactions of proteins could be resulted from homodimerisation or heterodimerisation. But these are quite specific and always selective in nature and act onlyon particular set of class of proteins, which provide substantial target behaviour to a drug designer. Here in this paper, provided a commentary based review compiling the short notes information provided on protein proteins interactions, by “Catherine Royer”

COMPARATIVE STUDY ON PROPHYLACTIC USE OF AMOXICILLIN AND CLAVULANIC ACID IN COMBINATION VS CEFTRIAXONE IN NEUROSURGERY WARD OF A TERTIARY CARE HOSPITAL WITH ASSESSMENT OF RESISTANCE RATE IN NEUROSURGERY TO ANTIMICROBIALS

ABOUT AUTHORS:
Neehar Dixit, Arun Kumar, Prashant mathur, Preeti kothiyal
Department of clinical pharmacy
Division of Pharmaceutics
SGRRITS, Patel Nagar
Dehradun, 248001
Uttarakhand, India
neehar.dixit007@gmail.com

ABSTRACT
Antimicrobial agents are among the most commonly prescribed drugs and account for 20% of the hospital pharmacy budget. The present study was designed to observe and compare the prophylactic use of antibiotics (amoxicillin+clavulanic acid vs ceftriaxone) in neurosurgery ward of a tertiary care hospital with assessment of resistance rate in neurosurgery to antimicrobials. Total no of 250 patients were included in the study, in this study inclusion of 232 patients  were receiving amoxicillin+clavulanic acid or Ceftriaxone for prophylaxis in neurosugery. The following parameters were included- reduction of fever, reduction of exudates, depression or disappearance of pathogenic bacteria, overall clinical improvement, complications and length of hospitalization stay. Test of significance of two real ratios was applied and the value of Z indicated (Z=36) which is highly significant hence two ratios are not equal. It implied that ceftriaxone was better than amoxicillin+clavulanic acid. Present study conclude that the resistance rate of penicillins is higher than ceftriaxone in neurosurgery ward. Data  also shows that ceftriaxone is the better choice of treatment and it reduces the hospitalization stay of patients and lead to less burden on patient.

ADDITIVES IN PHARMACEUTICAL GELS: A REVIEW

ABOUT AUTHORS:
Bhatt Preeti *, Gnanaranjan. G , kothiyal Preeti
Department of pharmaceutics,
Shri Guru Ram Rai Institute Of Pharmacy,
Dehradun-248001, India
*preetibhatt03@gmail.com

ABSTRACT
The motto of writing this review on additives in pharmaceutical gel was to compile the recent literature with special focus on rational approach to topical formulation and basic components used in gel for topical drug delivery systems. Topical drug delivery systems involve the introduction of a drug to the surface of the body, in a formulation which can be absorbed. Topical gels are intended for skin application or to certain mucosal surfaces for local action or percutaneous penetration of medicament or for their emollient or protective action as they show better potential as a vehicle to administered drug topically in comparison to ointment. Additives are inactive ingredients used for structuring dosage form. Selection of topical vehicles depends on various dermatological factors and pharmaceutical factors. Dermatological factors are absorption penetration, skin condition, compatibility, emollient properties. Pharmaceutical factors are stability, solvent properties, emulsifying property.  The choice of suitable exepient for a formulation development is made on the basis of the drug delivery requirements and the particular need to impart sufficient emolliency or other quasi-medicinal qualities in the formulation.

REVIEW ON BETA- CYCLODEXTRIN INCLUSION COMPLEX: A MORDEN APPROACH FOR DRUG DELIVERY

ABOUT AUTHORS:
Bhatt Anjali*, Goshwami Lakshmi,  Papola Vibhooti, Pathak Namita, Rawat Shuveksha
Shri Guru Ram Rai Institute of Technology and Science,
Dehradun 248001, Uttrakhand India
*anjali23mar@gmail.com

ABSTRACT
Cyclodextrins were first described by Villiers in 1891. Schardinger laid the foundation of the cyclodextrin chemistry in 1903 and identified cyclodextrin. In the 1930s, Freudenberg identified cyclodextrin and suggested that larger cyclodextrins could exist. Freudenberg and co-workers showed that cyclodextrins were cyclic oligosaccharides formed by glucose units and somewhat later Cramer and co-workers described their ability to form inclusion complexes. By the early 1950s the basic physicochemical characteristics of cyclodextrins had been discovered, including their ability to solubilize and stabilize drugs. The first cyclodextrin-related patent was issued in 1953 to Freudenberg, Cramer and Plieninger. However, pure cyclodextrins that were suitable for pharmaceutical applications did not come available until about 25 years later and at the same time the first cyclodextrin-containing pharmaceutical product was marketed in Japan. Later cyclodextrin-containing products appeared on the European market and in 1997 also in the US. This review aims to assess the use of cyclodextrin in newer drug delivery system such as nanosponges, nanoparticles, nanospheres, liposomes and other drug delivery system.

CURRENT AND FUTURE TREND IN NANOTECHNOLOGY: A REVIEW

ABOUT AUTHORS:
Anjali* , Lakshmi Goswami, Dr. Preeti Kothiyal
Shri Guru Ram Rai Institute of Technology and Sciences
Patel nagar, Dehradun
anjali23mar@gmail.com

ABSTRACT
In field of nanotechnology nonmaterial are at the leading edge. Nanotechnology has received a lot of attention with enthusiasm because of its future potential. Their unique size-dependent properties make these materials greater and indispensable in many areas of human activity. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. Polymeric nanoparticles have been extensively studied as particulate carriers in the pharmaceutical and medical fields, because they show promise as drug delivery systems as a result of their controlled and sustained release properties, subcellular size, biocompatibility with tissue and cells. This technology offers the advantage of protecting drugs from degradation; reduce the number of doses required. This brief review tries to summarise the most recent developments in the field of applied nanomaterials, nanoparticles, solid lipid nanoparticles, nanocrystals, nanosuspensions, nanoemulsions, in particular their application in biology and medicine, and discusses their commercialisation prospect.

WAFERS TECHNOLOGY – A NEWER APPROACH TO SMART DRUG DELIVERY SYSTEM

ABOUT AUTHORS:
Papola Vibhooti *, Dr. Kothiyal Preeti
Shri Guru Ram Rai Institute of Technology & Sciences
Dehradun, Uttarakhand, India
*papola.vibhooti47@gmail.com

ABSTRACTS
The lyophilized wafer developed throughout this review is an effective and versatile drug delivery system for oramucosal application. This has been established from the extensive physicochemical and physic mechanical profiling conducted. Through a screening and selection of polymers, HPC had the lowest gelation characteristics and was therefore suitable for the development of the wafer system. Suitable excipient and polymer combinations were established which allowed for the development of rapidly disintegrating and prolonged release wafer systems. The wafer system containing HPC, lactose, mannitol and glycine had the ability to disintegrate within 30 seconds. The modified wafer system, consisting of pectin cross linked with zinc ions serving as the drug reservoir, and mucoadhesive polymer combination of pectin, carmellose and gelatin, provided effective release of model drug diphenhydramine hydrochloride over approximately six hours. The modification of this technology to provide a prolonged release mucoadhesive system seems promising. It is envisaged that this system will be applicable to many drugs requiring the extended release of bioactive material. Therefore, the lyophilized wafer matrices developed in this study are highly effective in the rapid delivery of drugs, using the oral route as a site of administration.

A REVIEW : APPROACH IN DENTAL DRUG DELIVERY SYSTEM

ABOUT AUTHORS:
Badola Ashutosh,* Nishu Sharma
Shri Guru Ram Rai Institute of Technology & Science ( SGRRITS ),
Dehradun 248001, Uttarakhand , India
*ashutosh.badolam.pharma@gmail.com

ABSTRACT:
Controlled release local drug delivery systems offer advantages compared to systemic dosage forms for periodontitis. The objective of this research was to design and evaluate sustained release dental films containing drug in a non-biodegradable polymer for targeted delivery of the drug. The polymer ethyl cellulose was used in the formulation of dental films. The dental film was then evaluated for various parameters like thickness, folding endurance, and weight variation, and content uniformity, in vitro and in vivo study. Drug release profile of the dental film showed that the film exerted an initial burst release followed by a sustained release of the drug and the drug release was well above the minimum inhibitory concentration throughout the time of study. The release data obtained were subjected for release kinetics study. The study suggested that the non-biodegradable based dental film is a potential local drug delivery device for the treatment of periodontitis.