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Seth G.L. Bihani S.D. College of Technical Education

academics

 

Clinical research courses

  • COMBINATORIAL CHEMISTRY - MODERN SYNTHESIS APPROACH

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    ABOUT AUHTORS
    Sunil Shastri*, Harsh Narang.
    Seth G.L. Bihani S.D. College of Technical Education,
    Sriganganagar, Rajasthan.
    sunil11044@gmail.com

    ABSTRACT
    The Combinatorial Chemistry is a scientific method in which a very large number of chemical entities are synthesized by condensing a small number of chemical compounds together in all combinations defined by a small set of chemical reactions.

    Combinatorial technologies provided a possibility to produce new compounds in practically unlimited number. New strategies and technologies have also been developed that made possible to screen very large number of compounds and to identify useful components of mixtures containing millions of different substances. Instead of preparing and examining a single compound, families of new substances are synthesized and screened. In addition, combinatorial thinking and practice proved to be useful in areas outside the pharmaceutical research Such as search for more effective catalysts and materials research. Combinatorial chemistry became an accepted new branch within chemistry.
    The aim of this project is to provide a basic introduction to the field of combinatorial chemistry describing the development of major techniques and some applications. 

  • PRESCRIBING TREND OF ANTIHYPERTENSIVE DRUGS IN SRI GANGANAGAR DISTRICT: A RETROSPECTIVE STUDY

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    ABOUT AUTHORS:
    Amarjeet Singh*, Sudeep Bhardwaj, Ashutosh Aggarwal
    Department of Pharmacology,
    Seth G. L. Bihani S. D. College of Technical Education,
    Institute of Pharmaceutical Sciences & Drug Research,
    Sri Ganganagar, Rajasthan 335001, India
    *amarjeetsingh024@gmail.com

    ABSTRACT
    Objective
    : The choice of drug for the treatment of hypertension changes at short intervals. Drug utilization studiesconducted at regular intervals help to guide the physician in prescribing drugs rationally. The present study was done toanalyze the prescribing patterns of antihypertensive drugs in a NorthIndian  hospital.

    Material & method: A retrospective, crosssectional analysis of prescriptions of antihypertensive cases admitted in Medicine in-patient wards of civil hospital of Sri Ganganagar was conducted. All the prescription files with diagnosis ofessential hypertension were analyzed. Prescriptions for hypertension with other co-morbid conditions were also included. Frequency and proportions of utilization of antihypertensive medications were charted and figured.

    Result: During the studyperiod, there were 435 prescriptions for essential hypertension. The most frequently prescribed antihypertensive medications were:  monotherapy (42.06%), (57.94%) of patients were on multiple drugtherapy, the most favored fixed drug combination being diuretics with angiotensin receptor blockers (31.74%).

    Conclusion: The present study revealed that Angiotensin receptor blockers arethe drugs of choice as monotherapy and as combination therapy for hypertensives. This pattern of prescription is also supported by the current JNC VIII guidelines for the treatment of hypertension.

  • RISK ASSESSMENT OF DEVELOPING TYPE 2 DIABETES MELLITUS IN PATIENT ON ANTIHYPERTENSIVE MEDICATION

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    ABOUT AUTHORS
    Amarjeet Singh*, Sudeep bhardwaj, Ashutosh aggarwal
    Department of Pharmacology,
    Seth G. L. Bihani S. D. College of Technical Education,
    Institute of Pharmaceutical Sciences & Drug Research
    amarjeetsingh024@gmail.com

    ABSTRACT
    Objective:
    The purpose of this study was to examine the risk assessment of developing type 2 diabetes mellitus in patient on antihypertensive medication.

    Material & Method: In the present study total 30 patient with essential hypertension of both sex with mean age (48.6±0.8313) were recruited as per the inclusion criteria. Patients were segregated on the behalf of therapy they were using. 22 patients were on Losartan+HCTZ therapy and 8 patients were on Atenolol therapy.

    Result: After six month of antihypertensive therapy Atenolol group showing a significant difference in their blood glucose (0.0014) whereas in Losartan+HCTZ group significant difference was not observed (0.1542). Patients of Atenolol group when compared with patient of Losartan+HCTZ group a significant difference was observed in the serum cholesterol level (0.0290).

    Conclusion: We found that the use of β-blocker was independently associated with increased risk of type 2 diabetes. So increase in blood glucose in the Atenolol group patient revealed a significant association between use of Atenolol therapy and metabolic dysfunction whereas in Losartan+HCTZ group significant increase in blood glucose was not observed and from these we can conclude therapy with Losartan+HCTZ therapy not associated with metabolic dysfunction.

  • MICROENCAPSULATION: ADVANCEMENTS IN TECHNOLOGY AND ITS PATENTS

    About Authors:
    Arsh Chanana*, Mahesh Kumar Kataria, Ajay Bilandi
    Department of Pharmaceutics, Seth. G.L. Bihani S.D. College of Technical Education,
    Sri Ganganagar (Rajasthan) INDIA
    *arshchanana806@gmail.com

    Abstract-
    Microcapsule is a tiny sphere including core material/internal phase or fill, coated with/surrounded by wall know as shell, coating or membrane. The usual size range of the microcapsule lies between 1 to 1000 μm. The technique is usually applied for targeted drug delivery, protection of the molecule and stability if the core material. Microencapsulation system offers potential advantages over conventional drug delivery systems and also established as unique carrier systems for many pharmaceuticals. This article contains the traditional and the recent techniques, including their patents, for the preparation of microcapsules. Solvent exchange method, coacervation, polymerization, hot melts etc are several recent techniques are used for the preparation of the microcapsules. The microencapsulation technique, as Novel drug Delivery System (NDDS), is widely applied for delivery of probiotics, drugs, pesticide, food etc. Although significant advances have been made in the field of microencapsulation, still many challenges need to be rectified during the appropriate selection of core materials, coating materials and process techniques.

  • VISIBLE RESIDUE LIMIT- SCOPE OF IMPROVEMENT

    ABOUT AUTHOR:
    Arsh Chanana
    Department of Pharmaceutics,
    Seth G.L. Bihani S.D. College of Technical Education Sri Ganganagar.
    arshchanana@ymail.com

  • Garlic (Allium sativum) : Potential Clinical Benefits & Garlic Preparations

    About Authors:
    Sharma Monish*, Kumar Bhupender
    Seth G.L Bihani S. D. College of Technical Education,
    Institute of Pharmaceutical Sciences & Drug Research.
    Sri Ganganagar, Rajasthan (INDIA)

    *monish28sharma@gmail.com

    Introduction :
    The name “Allium sativum” is derived from the Celtic word “all”, meaning burning or stinging, and the Latin “sativum” meaning planted or cultivated. The English word, garlic, is derived from the Anglo-Saxon “gar-leac” or spear plant, referring to its flowering stalk.(Kemper J Kathi.2000)
    Garlic (Allium sativum), a member of the Liliaceae family, is a common food for flavour and spice  and it is one of the herbs most commonly used in modernfolkloric medicine. Garlic was an important medicine to theancient Egyptians as listed in the medical text Codex Ebers(ca.1550 BC) especially for the working class involved in heavy labour because it was an effective remedy for many aliments such as heart problems, headache, bites, worms and tumours. In 1858, Pasteur noted garlic’s antibacterial activity, and it was used as an antiseptic to prevent gangrene during World War I and World War II. (Thomson Martha.et.al.2007, Tattelman Ellen.2005)

  • HERBS AND THEIR INTERACTION WITH ALLOPATHIC DRUGS – A REVIEW

    About Authors:
    Sharma Monish*, Kumar Bhupender, Bhardwaj Sudeep
    Seth G.L Bihani S. D. College of Technical Education,
    Institute of Pharmaceutical Sciences & Drug Research.
    Sri Ganganagar, Rajasthan (INDIA)
    *monish28sharma@gmail.com

    ABSTRACT :
    During the recent past, a dramatic rise in the use of herbs and herbal remedies has been witnessed in many parts of the world.  While such products had been used with apparent safety in traditional societies for many centuries, when they are being combined with pharmacological agents, posses the possibility of potential interaction between the two groups of substances. In this situation, herb-allopathic drug interaction is an important factor to be measured because there is always a chance to get undesirable therapeutic effect of the prescribed allopathic drug, as like allopathic (prescription) drugs. Herbal medicines also have different pharmacokinetic and pharmacodynamic properties which ultimately lead to produce therapeutic responses, but sometimes cause adverse actions and/or drug-herbal interactions. Drug interaction refers to the situation where two or more separate drugs have been absorbed into the body and their effects are affected by each other, i.e. the effects are increased or they produce a new effect that neither produces on its own. The aim of this article is to highlight the interactions between herbal remedies and prescribed drugs.

  • QUALITY CONTROL TESTING OF PACKAGING MATERIALS

    About Author:
    Sahil Jasuja1*, Mahesh Kumar Kataria2
    1Department of Quality Assurance,
    2Assistant Professor
    Seth G.L. Bihani S.D. College of Technical education (Institute of Pharmaceutical Sciences & Drug Research),
    Sri Ganganagar, (Raj.), India.
    *sahiljasuja@rediffmail.com

  • CROSSOVER DESIGNS AND BIOAVAILABILITY STUDY WITH STATISTICAL ANALYSIS: A REVIEW

    About Authors:
    Bhupender Kumar*, Prof. Sudeep Bhardwaj, Monish Sharma, Ramchandra
    Seth G.L. Bihani S.D. College of Technical Education (Institute Of Pharmaceutical Sciences
    And Drug Research), Sri Ganganagar, Rajasthan, 335001
    *bhupendra.nimiwal@gmail.com

    ABSTRACT:
    In a typical crossover design, each subject takes each of the treatments under investigation on different occasions. Comparative bioavailability or bioequivalence studies, in which two or more formulations of the same drug are compared, are usually designed as crossover studies. Perhaps the greatest appeal of the crossover design is that each patient acts as his or her own control. This feature allows for the direct comparison of treatments, and is particularly efficient in the presence of large inter individual variation. However, caution should be used when considering this design in studies where carryover effects or other interactions are anticipated. Under these circumstances, a parallel design may be more appropriate.

  • A REVIEW ON INSTRUMENTATION OF THERMAL ANALYSIS METHOD: DTA, DSC

    About Authors:
    Bhupender Kumar*, Assit. Prof. Prasant Beniwal, Monish Sharma, Ramchandra
    Seth G.L. Bihani S.D. College of Technical Education
    (Institute Of Pharmaceutical Sciences And Drug Research),
    Sri Ganganagar, Rajasthan
    *bhupendra.nimiwal@gmail.com

    Abstract:
    Thermoanalytical methods essentially techniques that are based entirely on the concept of heating a sample followed by well-defined modified procedures, such as : gravimetric analysis, differential thermal analysis (DTA) and differential scanning calorimetry (DSC). Thermogravimetric analysis measured weight change, differential scanning calorimetry measured heats and temperature of transitions and reactions, differential thermal analysis (DTA) measured temperatures of transitions and reactions.

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