Review Articles

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  • PharmaTutor
    18 January 2016

    PHARMACOLOGY OF COMBINED MESALZINE AND RIFAXIMIN THERAPY TO INFLAMMATORY BOWEL DISEASE

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    ABOUT AUTHORS
    Prajapati Krishna V*, Raj Hasumati A, Jain Vinit C, Prajapati Neelam S.
    Department of Quality Assurance,
    Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India
    *krish1112k@gmail.com

    ABSTRACT
    This review article presents the pharmacology of combined Mesalazine and Rifaximin therapy especially in inflammatory bowel disease. Mesalazine is used as in anti-inflammatory agent, Non-Steroidal. Rifaximin is used in Gastrointestinal Agents, Anti-infective agent. The use of Rifaximin in combination with Mesalazine has been proved to provide beneficial effect in inflammatory bowel disease. The mechanism of Mesalazine and Rifaximin is quite different. Mesalamine and Rifaximin are two different types of drugs offering some symptomatic relief to the IBD patients. Mesalamine treats inflammation, whereas, Rifaximin reduces bio burden.
    Patent for combination of both drugs were approved by WIPO. The main objective of this review article is to provide pharmacological information of combined therapy of Mesalazine and Rifaximin to researcher in development of combined dosage form of this.

  • 11 January 2016
    BIOTECHNOLOGICAL/BIOLOGICAL PRODUCTS: ABOUT ITS STABILITY TESTING

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    ABOUT AUTHORS
    Vivek P. Chavda1*, Dharmesh Shaliya2, Bhargav Patel3, Ashish Gabani4
    1Department of Pharmaceutics, B.K. Mody Government Pharmacy College, Rajkot, Gujarat, India
    2Quality Assurance, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat, India
    3Quality Assurance, Zydus cadila pharmaceuticals Ltd., Ahmedabad, Gujarat, India
    4 Intas Biopharmaceuticals Ltd., Ahmedabad, Gujarat, India
    * vivek7chavda@gmail.com

    ABSTRACT
    The drug delivery systems have made some of the technological advances especially in the case of biopharmaceuticals. When one talks about biotechnological product stability of drug product becomes main culprit due to dynamic nature of drug molecule. This review is grafted using ICH and other regulatory guidelines to provide an overview to stability testing of such molecules.

  • 4 January 2016
    A REVIEW ON: PRESERVATIVES USED IN PHARMACEUTICALS AND IMPACTS ON HEALTH

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    ABOUT AUTHORS
    Sabir M. Shaikh*1, Rajendra C. Doijad1, Amol S. Shete1, Poournima S. Sankpal2
    1 Department of Pharmaceutics, Shree Santkrupa College of Pharmacy, Ghogaon, Karad, Maharashtra, India.
    2 Department of Pharmaceutical chemistry, Shree Santkrupa College of Pharmacy, Ghogaon, Karad, Maharashtra, India.
    *sabirmshaikh17@gmail.com

    ABSTRACT
    For several decades pharmacist have been aware of the need to protect their products against microbial contamination but it is only during the last one or perhaps two decades the serious thought of has been applied to the science of preservation. Preservatives are commonly used as additives in pharmaceutical products, food and cosmetics. Some of the liquid preparation are susceptible to microbial contamination because of the nature of ingredients present in it. Such preparation are protected by preservatives which avoids degradation and alteration of the product.A preservative is a natural or synthetic chemical added to various products which helps to prevent microbial decomposition. Present article deals with the study of ideal properties, classification, mechanism of action, Pharmaceutical applications and its impact on health of various preservatives used in pharmaceuticals.

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  • 21 December 2015
    A SHORT REVIEW ON RHEUMATOID ARTHRITIS (RA)

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    ABOUT AUTHORS
    Sabya Sampad Swain, Nadugopal Bhuyan, Chaitanya Prasad Meher
    Gayatri institute of science & technology (GIST), Gunupur, Rayagada, Orissa
    swainsabhya@gmail.com

    ABSTRACT
    Rheumatoid arthritis is most common disease in India as well as outside India. The Centers for Disease Control and prevention estimates that more than 40 million Americans have some form of arthritis or chronic joint disorder out of them 7 million Americans suffer from arthritis in its most debilitating forms. Arthritis foundation classified rheumatic diseases as inflammatory disorders affecting more & more individuals than any chronic illness. Osteoarthritis is the most common form of arthritis in the United States, affecting about 12% of Americans between the ages of 25 and 74. Rheumatoid arthritis is thought to affect well over 2 million Americans (two to three times more females more than males), whereas juvenile arthritis affects 71,000 children under 16 years of age, 61,000 of whom are females. The presented article is concern with a brief idea about rheumatoid arthritis.

  • 10 December 2015
    DATA INTEGRITY AND WORLDWIDE REGULATORY GUIDANCE

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    ABOUT AUTHORS
    Rohit A. Patil1*, Shruti N.Patil2
    Department of Regulatory Affairs,
    Supreme Pharma Healthcare Pvt. Ltd. Mumbai, MH, India
    * rohitpharma3250@gmail.com

    ABSTRACT
    Good storage of data & record management are critical elements of pharmaceutical quality system. Data integrity refers to maintaining & assuring the accuracy & consistency of data over its entire life –cycle in compliance with its applicable regulatory requirements.
    Data integrity is mandatory for the regulated pharmaceutical industry, as processing and disposition decisions regarding product quality, safety, efficacy, purity, and compliance with the applicable regulatory requirements are made based on data that is recorded and reported. Data integrity risk should be assessed, mitigated, communicated & reviewed throughout the data life cycle. Healthcare industries should be designed Record-keeping methodologies and systems, in a way that encourages compliance and assures data quality and reliability.

  • 6 December 2015
    REVIEW STUDY ON FACTORS AFFECTING THE PRESCRIPTION PATTERN OF PHYSICIANS

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    About Authors
    Amoah-Binfoh Kenneth1*, Pradhyuman Singh Lakhawat1, Archana Chandra2
    1 SHIATS, Allahabad, UP, India
    2 Dept. of Human Resources, SHIATS, Allahabad, UP, India
    * geokin08@gmail.com

    ABSTRACT
    Prognosis the medical outcome of a corrective prediction, physicians become aware of a particular drug through promotional strategies. If all relevant information received is positive, the drug may be tried on few patients’. As a matter of fact if the outcomes of the trials are acceptable physicians will shift and may be more interested to prescribe the drugs consistent. Prescribing drugs is a standard component of most physicians’ practices. It is an important area of practice that requires appropriate knowledge, skill and professional judgment. To improve patient safety when prescribing, these qualities set out expectations for physicians who prescribe drugs. However in connection with the physician’s prescription pattern, Indian pharmaceutical industry is at a turning point. The pharmaceutical firms have to change their strategies for the challenges ahead. Quality systems, innovation, manufacturing and marketing competence are associate factors that affects physicians prescription pattern. The efficacy of drug discovery process has been reported to have suffered a major transformation. New drug discovery has to be strictly adhere to the tight intellectual property rights to ensure effective and efficient, prescriptions and protections. Further clinical and behavioral characteristics of the patient, research and the pressures from drug firms, high curing effect; habitual or non-habitual choice, behavior pattern of patients, peer influence of physicians (community of physicians) and education and advertising are reviewed factors affecting physician’s prescription pattern.

  • 12 November 2015
    A REVIEW ON: PHYSICOCHEMICAL EVALUATION OF AYURVEDIC MINERAL DRUG TANKAN BHASMA

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  • 21 October 2015
    A REVIEW ON ANALYTICAL METHODS FOR RANOLAZINE DETERMINATION IN SYNTHETIC MIXTURE

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  • 20 October 2015
    BESTOWING PHARM.D TO THE ERA OF HEALTHCARE TECHNOLOGY AND PATIENT SAFETY

    ABOUT AUTHORS:
    Tarun Singh
    India’s Leading Drugs Consultant
    SSJ Hospital
    doctarunsethi@gmail.com

    Advancement in health and medicine has enhanced the life expectancy of human beings. For last hundred years' medicinal processes and medical equipment are proved to be the boon to human health for diagnosing properly and for applying proper medicines to the patient.

    Medicine is considered as one of the most important necessity to all of us. It is derived from the Latin words arsmedicina meaning "the art of healing". Medicine and Drugs are the synonyms.  Drugs is concerned with maintaining or restoring human health through the study, diagnosis, treatment and possible prevention of disease, injury and other damage to a body or mind. It ignites the human mind to initiate more research to find other sophisticated technology for adding value to medical science. Due to consistent effort of doctors and scientists now we have latest medical equipmentfor diagnosis, High quality medicine packaging machines, Computerised blood testing machines, digital & robotic testing machines.

  • 27 September 2015
    TOMATO CUISINES: A DELECTABLE REJOINDER TO THREAT OF CHRONIC AILMENTS?

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    ABOUT AUTHORS:
    Vikram S. Chauhan1*, Bina Rani2, Priyanka Bishnoi3, Raaz K. Maheshwari3
    1    Department of Botany, SBRM Govt PG College, Nagaur, Rajasthan, India
    2Department of Engineering chemistry & Environmental Engineering, Poornima College of Engineering, Jaipur, India
    3Department of Chemistry, SBRM Government PG College, Nagaur, Rajasthan, India
    *vikkysingh2000@yahoo.com; rkmgreenchem.jaipur@gmail.com

    ABSTRACT
    With the advent of modern times, stress and pollution have led to major effect on rise of death toll due to chronic diseases. Such diseases are major cause of concern for the medical society. Lycopene, a carotenoid pigment found in tomatoes and its products has antioxidant properties due to the presence of numerous double bonds. Increased consumption of lycopene containing diet has been proposed to offer a protection against many types of cancers and cardio-vascular diseases. Its potential role as nutraceutical has been suggested in many studies. The present review deals with fundamental biochemistry, bio-availability and benefits of lycopene rich diet and its relation with some chronic diseases like various forms of cancers and cardiovascular diseases.

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