Madhya Pradesh

ZALTOPROFEN: AN EFFECTIVE NSAID FOR PAIN MANAGEMENT

ABOUT AUTHORS:
Saxena Vaishali*, Bhale Shweta, Dantoriya Sanjay, Mathariya Arun k., Mahajan S.C., Bhandari Govind
Mahakal Institute of Pharmaceutical studies,
Ujjain (m.p)
*vaishali.saxena0390@gmail.com

ABSTRACT:
Pain management is important for ongoing pain control, especially if you suffer with long-term or chronic pain. NSAIDs or nonsteroidal anti-inflammatory drugs are among the most common pain relief medicines in the world. Every day more than 30 million peoples use them to soothe headaches, sprains, arthritis symptoms, and other daily discomforts, according to the American Gastroenterological Association. Propionic acid derivatives are widely regarded as the drugs of first choice in the management of patients with inflammatory joint disease because they are the class of NSAIDs with the lowest incidence of side effects. Zaltoprofen (ZLT) is a propionic acid derivative of non steroidal anti inflammatory class, which has excellent effect on post-surgery or post trauma chronic inflammation of the drug. So, Zaltoprofen may serve as a potent and superior analgesic for the treatment of pain. Zaltoprofen has the dose of 80 mg three times a day which reduce patient compliance and used in the treatment of rheumatoid arthritis, osteoarthritis, and other chronic inflammatory Pain conditions. ZLT has recently been reported to cause potent inhibition of cyclooxygenase-2 with fewer side effects on the gastro-intestinal tract than other non steroidal anti inflammatory drugs.

NANOROBOTICS - AN EMERGING TREND FOR CANCER TREATMENT

About Authors:
Prabhakar Sharma*1, Prakash Pandey1, Ramchandra Gupta1, Ashish Garg2, Prateek Jain3
1Department of Pharmacognosy
2Department of Pharmaceutics
3Department of Pharmacy
Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy) Jabalpur, M.P.
*mr.pks19@gmail.com

Abstract
Size reduction is one of most fundamental unit operation which is of prime importance in pharmacy. It helps in improving stability and bioavailability, reducing toxicity, enhancing release and providing better formulation opportunities for drug. Nanotechnology involves the engineering of molecularly precise structures and,ultimately, molecular machines. This paper presents the study of nanorobotscontrol activation for stenosed coronary occlusion, with thepractical use of chemical and thermal gradients for biomedicalproblems. This review paper describes all the information about pharmaceutical nano-robots, their types, components mechanismetc.

FORMULATION AND CHARACTERIZATION OF MELOXICAM LOADED MICROEMULSION FOR THE TREATMENT OF RHEUMATOID ARTHRITIS

ABOUT AUTHOR:
Verma Siddharth
Sri Ram Institute of Technology,
ITI Jabalpur M.P. 482003
luckyverma84@gmail.com

ABSTRACT
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. The process produces an inflammatory response of the synovium (synovitis) secondary to hyperplasia of synovial cells, excess synovial fluid and the development of pannus in the synovium. Various treatments are available. Non-pharmacological treatment includes physical therapy, orthoses, occupational therapy and nutritional therapy. Analgesia (painkillers) and anti-inflammatory drugs including steroids are used to suppress the symptoms, while disease-modifying antirheumatic drugs (DMARDs) are often required to inhibit or halt the underlying immune process and prevent long-term damage. In recent times, the newer group of biologics has increased treatment options.

A REVIEW ON PARASITIC WORMS AND ANTHELMENTIC DRUG

About author:
Priya Diwedi
M.Pharm
Bhopal institute of technology and science-pharmacy, Bhopal (M.P)
Priya.diwedi07@gmail.com

ABSTRACT:
Anthelmintics or antihelminthics are drugs that expel helminth parasitic worms (helminths) from the body, either by stunning or killing them. They may also be called vermifuges (stunning) or vermicides (killing). They belong to two major groups of animals, the flatworms or Platyhelminthes (flukes and tapeworms) and the roundworms or Nematoda. Albendazole, mebendazole and praziquantel are the commonly used drugs acting as anthelmintics having broad spectrum activity and high cure rates due to the sustainability of the periodic emergence of resistance. This article reviews the worm infection, their lifecycle and its outcome, symptoms of worm infection and its prevention,marketed formulation for anthelmentic activity and their limitation and herbal drug used for anthelmentic activity.

HERBAL TREATMENT AND RHEUMATOID ARTHRITIS: AN OVERVIEW

About Authors:
Prabhakar Sharma*1, Prakash Pandey1, Sunil Roshan1, Ashish Garg2, Vikas Pandey3, Anil Pasi4
1Department of Pharmacognosy, GRKIST (Pharmacy), Jabalpur, M.P.
2Department of Pharmaceutics, GRKIST (Pharmacy), Jabalpur, M.P.
3Department of chemistry, RDVV, Jabalpur, M.P.
4College of pharmacy, IPS academy, Indore, M.P.
*mr.pks19@gmail.com, pksmp11@gmail.com

Abstract
Sometimes Herbal medicines are referred as herbalism or natural medicine is the use of herbs for their therapeutic or medicinal value, an herb is a plant or plant part valued for its medicinal, aromatic or savory qualities. Herb plants produce and contain a variety of chemical substances that act upon the body herbalism has a long tradition of use outside of conventional medicine. It is becoming more main stream as improvements in analysis and quality control along with advances in clinical research show the value of herbal medicine in the treating and preventing disease. By definition, ‘traditional’ use of herbal medicines implies substantial historical use, and this is certainly true for many products that are available as ‘traditional herbal medicines’.

NUTRACEUTICALS

ABOUT AUTHORS:
Miss Apoorva Bhatnagar1, Dr. S. C. Mahajan2
1Mahakal institute of pharmaceutical studies,  
2Director at Mahakal Institute of Pharmaceutical Studies,
Ujjain (m.p.)  456010
*apy1590bhtngr@gmail.com

ABSTRACT:
Foods and food habits in today’s lifestyle have lead to the disturbances in an ideally nutritionally balanced body. Therefore in such state if “food be your medicine” then it would be great to achieve a healthy body and mind. The article covers major food products and nutraceuticals and their role they play in human health.

IMPURITY PROFILE: - STUDY A BETTER WAY FOR QUALITY CONTROL OF PHARMACEUTICALS PRODUCTS

ABOUT AUTHORS:
*Ramchandra Gupta2, Prabhakar Sharma2, Prakash Pandey2, Pratik Jain1, Ajay Shukla3
1Department of Pharmacognosy,
2Department of Pharmaceutics,
3Department of Pharmaceutical Chemistry

1,2,3Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy) Jabalpur, 483001, M.P.
*ramchandra.gupta667@gmail.com

ABSTRACT
In the pharmaceutical world, an impurity is considered as any other organic material, besides the drug substance, or ingredients, arise out of synthesis or unwanted chemicals that remains with API’s. Pharmaceuticals impurities are the unwanted chemicals that remain or are generated during the formulation of medicines. The presence and quantity of impurities in pharmaceutical drugs can have a significant impact on their quality and safety, with the continuous pressure for increased industry productivity, there is urgent need for a systematic and comprehensive drug impurity profiling strategy. The impurities present in the drug are adversely affecting the quality of the drug product. There are various types of impurities like starting materials, intermediates, penultimate impurity, by product and degradation product. Impurity profiling helps in detection, identification and quantification of various types of impurities as well as residual solvents in bulk drugs and in pharmaceutical formulations. It is a best way to characterize quality and stability of bulk drugs and pharmaceutical formulations. This review paper deals with the impurity profile of pharmaceuticals.

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