Madhya Pradesh

  • PharmaTutor
    1 November 2012

    TARGETING INFLAMMATION TO TREAT DEPRESSION –A NEWER SCIENTIFIC APPROACH: A REVIEW

    About Authors:
    Mr. Satyanand Tyagi*, Patel Chirag J1, Asheesh Singh2
    *President, Tyagi Pharmacy Association & Scientific Writer (pharmacy), Chattarpur, New Delhi, India-110074.
    Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 52 Publications (44 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 52 publications, 11 are International Publications).
    He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders,     psycho-pharmacological agents as well as epilepsy.
    1Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
    2Research Associate, Center for Research and Development, Ipca Laboratories Ltd Ratlam, Madhya Pradesh, India-457114.
    *sntyagi9 @yahoo.com, +91-9871111375 / 9582025220

    ABSTRACT:
    Prior studies have suggested that depressed people with evidence of high inflammation are less likely to respond to traditional treatments for the disorder, including anti-depressant medications and psychotherapy. This study was designed to see whether blocking inflammation would be a useful treatment for either a wide range of people with difficult-to-treat depression or only those with high levels of inflammation. The study employed infliximab, one of the new biologic drugs used to treat autoimmune and inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. A biologic drug copies the effects of substances naturally made by the body's immune system. In this case, the drug was an antibody that blocks tumour necrosis factor (TNF), a key molecule in inflammation that has been shown to be elevated in some depressed individuals. Study participants all had major depression and were moderately resistant to conventional antidepressant treatment. Each participant was assigned either to infliximab or to a non-active placebo treatment. When investigators looked at the results for the group as a whole, no significant differences were found in the improvement of depression symptoms between the drug and placebo groups. However, when the subjects with high inflammation were examined separately, they exhibited a much better response to infliximab than to placebo.

  • 30 October 2012
    INTRODUCTION TO STEM CELL CRYOPRESERVATION – A NEWER PHENOMENON OF ENSURING THE LONGEVITY OF CHILD HEALTH: A CLINICAL REVIEW

    About Authors:
    Mr. Satyanand Tyagi*, Raghvendra1, Amlan Mishra2, Patel Chirag J3, Asheesh Singh4
    *President, Tyagi Pharmacy Association & Scientific Writer (pharmacy), Chattarpur, New Delhi, India-110074.
    Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 51 Publications (43 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 51 publications, 11 are International Publications).
    He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders as well as epilepsy.
    1    Department of Pharmaceutics, Aligarh College of Pharmacy, Aligarh, U.P, India-202001.
    2Department of Pharmacology, Smt. Vidyawati College of Pharmacy, Jhansi, U.P, India-284128.
    3Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
    4Research Associate, Center for Research and Development, Ipca Laboratories Ltd Ratlam, Madhya Pradesh, India-457114.
    *sntyagi9@yahoo.com,     +91-9871111375 / 9582025220

    ABSTRACT:
    The umbilical blood cord being rich in stem cells needs to be preserved by means of a new technique called cryopreservation. The Process whereby whole tissues or cells are preserved by cooling at very low temperatures is known as Cryopreservation. Stem cell cryopreservation is a relatively new phenomenon; it is one way of ensuring the longevity of child’s health. This is done by banking the baby’s umbilical cord blood affluent with stem cells. Stem cells are important as they can grow into tissues, even organs like the heart or liver. What is more, they have the awesome potential to revamp damaged tissues.

    Till date, over seventy diseases have been successfully treated with the help of stem cell stored in the cord blood. Research on stem cells has, by no means, abated. Scientists realizing their potential and worth are carrying out intensive research on their uses as well as ways preservation. Before preserving stem cells, a biological test is carried out to eschew the possibility of deadly diseases like various types of Hepatitis or HIV. That done, the cord blood cells are now stored by means of the technique under discussion- Cryopreservation. This technique involves adding a cryopreservant that lets the blood freeze gradually. The blood is frozen to sub-zero degree temperatures so that biochemical reactions or any other dangerous biological that could cause cell death may be arrested. Typically, the cells are stored at temperatures as low as -196, – 156, or – 120 degrees centigrade. Freezing stem cells through cryopreservation at such low temperatures is supposed to ensure their longevity. Let it be known, however, that scientists are still divided over the optimum temperatures as well as the efficacy of the cryopreservation technique itself. The aim of present article is to provide in depth knowledge about this technique of preserving stem cells of child i.e. the technique so called “Cryopreservation”. An attempt is also made to focus how this technique ensures the longevity of child’s health.

  • 12 September 2012
    CHARACTERISATION OF MARKER CHROMOSOMES

    About Authors:
    Masani Jigneshkumar Naranbhai
    School Of Science
    Biomedical Technology
    Jiwaji University, Gwalior
    jigneshmasani11@gmail.com

    ABSTRACT
    A supernumerary marker chromosome is an extra structurally abnormal chromosome of unknown origin. Various factors contribute to the difficulty of clarifying the phenotypicrisks of super numerary marker chromosomes (SMC), including differences inthe size, structure, and origin of marker chromosomes.

    All marker chromosomes do not contribute the same risk of recurrence. Therefore characterization of the marker chromosomes is of utmost importance for Genetic Counseling. Different molecular techniques can be used to identify the chromosome material present in the markers. In the present retrospective data analysis of 15,000 karyotypes of all patients referred to the Center of Medical Genetics, Sir Ganga Ram Hospital from 1998 to 2012. For constitution chromosome abnormality detection, we found fifteen (0.01%) patients had presence of the SMC. Of these fifteen, eight markers had been characterized after FISH was introduced in the year 2004.  This contributed to personalized Genetic Counseling and help for future pregnancies.

  • 11 September 2012
    Application are invited from B.Pharm, B, Sc, D.Pharm for Compounder in Lakshmibai National University of Physical Education Gwalior

    Applications in prescribed form are invited from the eligible Indian Nationals for the following posts at LNUPE, Gwalior and/or its NERC, Guwahati, as indicated against them, which are however transferable anywhere in India.

    Post:  Compounder 

  • 4 September 2012
    Zydus Cadila invites Chemists/Sr. Chemists/Officers Production, Chemists/Sr. Chemists/Officers: - Quality Control, Office/Executive - TT (Technology Transfer) - Baroda

  • 4 September 2012
    GC-MS ANALYSIS OF ACALYPHA INDICA LINN

    About Author:
    Manisha Singh
    Sagar Institute of Pharmacy & Technology,
    Gandhi nagar, Bhopal (M.P.)
    manishamasih85@gmail.com

    Abstract
    Acalypha indica Linn. consists of dried herb of Acalypha indica Linn. belonging to familyEuphorbiaceae. Within the Euphorbiaceae family, Acalypha indica is one of the biggest and most diverse, with nearly 450 species. Two thirds of its species are found in America, 19 of them in Venezuala, they are mainly used as ornamental, but with the rising of traditional medicine, these species are given medical properties painkillers, laxatives, anti-inflammatory and many others.The GC-MS analysis of methanol and acetone (70 : 30) extract prepared from the whole plant of Acalypha indica linn. revealed the presence of different phytochemicals.

  • 3 September 2012
    ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF WHOLE PLANT OF SIDA ACUTA (LINN.F.ND)

    About Authors:
    *Virendra Sharma, Pooja Sinoriya, Sunil Sharma
    Lakshmi Narain Academy of Pharmacy, Gwalior
    Kumud23@indiatimes.com

    Abstract
    To evaluate the anti-inflammatory and analgesic activity of methanolic extract of whole plant of Sida acuta in experimental animal models. Methanolic extract of whole plant of Sida acuta (MESA) (100, 200 and 400 mg/kg p.o.) was studied for its anti-inflammatory activity using Carrageenan induced rat paw edema animal model and analgesic activity at the same dose level using acetic acid induced writhing test and Hot plate analgesia in mice. The methanolic extract of whole plant of Sida acuta (MESA) (100, 200 and 400 mg/kg p.o.). The PI with indomethacin and Sida acuta in carrageenan induced paw edema  at the dose level 400 mg/kg were 60% and 52.5% at the end of 5 hr. In the acetic acid induced writhing test, the extract at the dose level 400 mg/kg showed 83.78% inhibition of writhing. In radiant heat tail- flick method the extract  at the dose 400 mg/kg showed reaction time 4.902 ± 0.545 (p<0.001). The methanolic extract possesses anti-inflammatory and analgesic activity.

  • 29 August 2012
    siRNA TECHNOLOGY:AN EMERGING TREND IN THERAPEUTICS

    About Authors:
    Vaibhav Patel*, Punit Bhatnagar, Gopal Rai, Alok Pal Jain
    Guru Ramdas Khalsa Institute of Science & Technology (Pharmacy),
    Jabalpur
    *vaibhavpatel281@gmail.com

    Introduction
    Gene therapy by small interfering RNAs (siRNAs) hasbeen emerging as innovative nucleic acid medicines with increasing knowledge on the molecular mechanisms of endogenous RNA interference. Gene silencingis a promising tool for the treatment of numerous human diseases that cannot be cured by rational therapies. The primary success of siRNA applications depends on suitable vectors to deliver therapeutic genes.

  • 26 August 2012
    EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF FICUS RELIGIOSA ON RATS AGAINST CCL4 AND PARACETAMOL INDUCED HEPATOTOXICITY

    About Authors:
    Vivek Chourasia*, Hemant Nagar, H.S. Chandel, Anindya Goswami
    Truba Institute of Pharmacy,
    Karond Gandhinagar Bypass
    Bhopal (M.P.)-India
    *vickyc.chourasia@gmail.com

    ABSTRACT
    Ficus religiosawas investigated for its possible protective effect against paracetamol and CCl4-induced hepatic damage. IV administration of a sub-lethal dose of paracetamol (500 mg/kg) produced liver damage in rats as manifested by the rise in serum level of transaminases (AST and ALT). Ttreatment of rats with Ficus religiosa (200 mg/kg) prevented the paracetamol-induced rise in serum enzymes. The hepatotoxic dose of CCl4 (1.5 ml/kg; orally) also raised the serum AST and ALT levels. The same dose of Ficus religiosa (200 mg/kg) was able to prevent the CCl4-induced rise in serum enzymes. These results indicate that Ficus religiosa possesses hepatoprotective activity.

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  • 13 August 2012
    STEVIA: AN EMERGING NATURAL SWEETENER FOR FOOD INDUSTRY

    About Authors:
    Singh Asheesh1*, Bajpai Dinesh1, Singour P.K.2
    1Centre for Research & Development, Ipca Laboratories Ltd; Sejavta; Ratlam (MP) - 457002
    2Faculty of pharmacy VNS Institute, Neelbud Bhopal (MP) - 462042
    *asheesh_parihar@yahoo.com

    Abstract:
    Stevia rebaudiana is a well known medicinal herb contains antibacterial, antifungal, anti-inflammatory, anti-viral, anti-yeast, cardiotonic diuretic and hypoglycaemic properties. This herb has been used in Ayurveda in India since centuries. Stevia is a perennial herb belonging to the family Asteraceae, is one of the most valuable tropical medicinal plant. All over world there is increasing tendency towards consuming natural products and thus living a natural life and. At the same time our life styles have changed so much over the last 4-5 decades that sweeteners (either high calorie natural or proceeded sugars or high potency and low calorie sweeteners such as Aspartame) have become integral part of our natural daily diet. Stevia is a new crop in that is gaining very high popularity amongst all type of sweetener users as most ideal substitute for sugar. Sugar is basically a chemical that has grown in market over last many years. But in this age of changing life styles and people becoming more conscious of their health, the worldwide sugar consumption is going down and is getting replaced by low calorie sweeteners. Many of these Sweeteners are complex chemicals or many times naturals as well.

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