Andhra Pradesh

Bharat Serums and Vaccines Limited (BSV) was founded by Dr. Vinod G. Daftary in 1971 to pursue the goal of introducing specialized healthcare products to meet the needs of a quality conscious market. The Company today researches, develops, manufactures, and markets injectable biological, pharmaceutical, and biotech products.

CSIR - CCMB is a premier constituent research Institute of the Council of Scientific and Industrial Research (CSIR), conducting research in frontier areas of modern biology. The objectives of the Centre are to conduct high quality basic research and training in the areas of modern biology, and promote centralized national facilities for new and modern techniques in the inter-disciplinary areas of biology.

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ABOUT AUTHORS
SRI HARSHA AYYAGARI.*HARI PRIYA MULLAMURI, SOWMYA  BYREDDY,   DURGA PRASAD T. S.
Sri Padmavathi School of pharmacy, Jawaharlal Nehru Technological University, Anantapuram, Andhra Pradesh, India.

ABSTRACT
Glanzmann's Thrombasthenia (GT) is a rare, autosomal recessive bleeding disorder characterized by prolonged bleeding time and impairment in aggregation of platelets and impairment in clot retraction. The physiological defect includes impairment of glycoprotein receptor’s (GPIIb/IIIa complex) present on platelet membrane which mediates platelet aggregation through fibrinogen binding. Purpose of this study is to get  all of us know about this rare condition. A 16-year old female patient presented with repeated episodes of menstrual bleeding since 4years. She was a k/c/o Glanzmann's thrombasthenia. She was treated with antifibrinolytics, IV fluids and then discharged. Early diagnosis and proper supportive care are the measures for prognosis of Glanzmann’s thrombasthenia.

Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

Post : Regulatory CMC Manager

Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

Post : Clinical Research Manager

USP is proud to be an equal opportunity/affirmative action employer. Employment selection and related decisions are made without regard to sex, gender identity, race, age, disability, religion, national origin, color, veteran status or any other protected class. We are committed to working with and providing reasonable accommodation to individuals with disabilities.

Post : Manager Bioanalytical

IISER Tirupati is the sixth Institute in the chain of IISERs established by the Govt. of India under the Ministry of HRD for imparting quality education in basic sciences and for setting up state-of-the-art research facilities for frontline and cutting-edge research in science. It started academic activity started in August 2015 in the spacious transit campus located at Sri Rama Engineering College, Rami Reddy Nagar, Karkambadi Road, Tirupati.

Post : Project Assistant/ Fellow

Koringa Educational Society was register in 2001. The aim of Koringa Educational Society (KES) is to the educational fruits to the nearby villages in the field of Pharmacy, medical lab technology, computer sciences and management studies.  Realizing the increasing importance of Pharmacy as a profession Sri. P. Kanaka Raju, Secretary of Koringa College of Pharmacy, Korangi, Tallarevu Mandal, near to Kakinada, East Godavari Dist., Andhra Pradesh.

Post : Professor, Associate Prof., Assistant Prof. and Lecturer

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ABOUT AUTHORS
A. PADMA¹*, D. GIRIJA², A. THIRUPATHIREDDY³, B. VENKATESWARAREDDY^4
1Department of Pharmaceutical Analysis, Sankar Reddy Institute of Pharmaceutical sciences, Salakalveedu(v), Bestavaripeta(M), Prakasam (Dist) Andhra Pradesh, India
²Department of Pharmaceutical Analysis, Sankar Reddy Institute of Pharmaceutical sciences, Salakalveedu(v), Bestavaripeta(M), Prakasam (Dist) Andhra Pradesh, India
³Department of Pharmaceutics, Sankar Reddy Institute of Pharmaceutical sciences, Salakalveedu(v), Bestavaripeta(M),Prakasam(Dist) Andhra Pradesh, India
⁴Department of Pharmaceutics, Sankar Reddy Institute of Pharmaceutical sciences, Salakalveedu(v), Bestavaripeta(M), Prakasam(Dist) Andhra Pradesh, India

ABSTRACT
The present research work deals with the development  and validation of  stability indicating RP-HPLC method for the simultaneous estimation of Aceclofenac and Drotaverin.HCl in bulk and formulation. Chromatographic separation was achieved on ODS HG-5 RP   C18(250 X 4.6 mm, 5 µm) using the mobile phase consisting of Acetonitrile and1% triethylamine (TEA) in the ratio of 90:10 pH  2.16 adjusted with Ortho phosphoric acid. The mobile phase was pumped at a flow rate of 1.0 mL/min and UV detection was observed  at 224 nm. The retention time was found to be 3.57 min for Aceclofenac and 6.15 min for Drotaverin.HCl. The linearity concentrations are obtained from in the range of 30-70 µg/ml for Aceclofenac and 24-56 µg/ml for Drotaverin.HCl respectively with correlation coefficient was 0.999 and 0.998. The proposed method was found to be simple, accurate, precise and reproducible and developed method can be suggest to routine quality control analysis for simultaneous estimation of Aceclofenac and Drotaverin.HCl in pharmaceutical dosage forms.