Uttar Pradesh

{ DOWNLOAD AS PDF }

ABOUT AUTHORS:
Vinit Raj*, Amit Rai, Deepak Kumar and Vinod Kumar
Department of Pharmaceutical Sciences,
Babasaheb Bhimrao Ambedkar University (A Central University),
VidyaVihar, Raebreli Road, Lucknow, Uttar Pradesh, 226025, India
*raj.vinit24@gmail.com

ABSTRACT
Epilepsy is a common brain disease that is characterized by recurrent and spontaneous seizures that result from abnormal and excessive synchronization of neuronal activity. Whereas, accumulation of Ca⁺⁺ in presynaptic terminals, leading to improved neurotransmitter release. In additional, depolarization-induced inauguration of the NMDA subtype of the excitatory amino acid receptor, which causes more Ca⁺⁺ influx and neuronal activation. The main aim of this study to focus on the deactivation of Ca⁺⁺ influx and prevent the augmentation of neuron activation. However, we performed molecular modeling of  novel 1,3,4-thiadiazole derivatives keeping in view structural requirement of pharmacophore and Quantitative structure activity relationship (QSAR) and evaluated in silico anticonvulsant activity. Docking procedures allow virtually screening a database of compounds and predict the strongest binder based on various scoring functions. In the docking study, targeted ligand  produced significantly affinity with the calcium channel receptor which is slightly higher than the phenytoin drug. A computational study was also carried out including prediction of pharmacokinetic properties, toxicity and bioactivity studies. All above parameter was calculated which exhibited slightly excellent compared than standard Phenytoin drug. The above observation suggested that these compounds would serve as better lead for anticonvulsant screening for future drug design perspective.

Vintage Labs is the one of the fastest growing pharmaceutical companies in India with registered office at Gurgaon having mix product therapy Like Antibiotics, Respiratory & Anti-Allergic, Nutraceuticals, Analgesics & Anti-inflammatory.

Post: Regional Sales Manager

I.T.S Group of Institutions has established the college in the year 2004 to impart high quality education in the field of pharmacy. The College (College code-170) is running B.Pharm & M.Pharm in Pharmaceutics, Pharmacology and Pharm Chem specialization, approved by AICTE and affiliated to M.T.U Noida and G.B.T.U, Lucknow. B.Pharm course is approved by Pharmacy Council of India upto 2012-13 session. The institute is also approved by G.B.T.U for Ph.D.

Central Institute of Medicinal and Aromatic Plants, popularly known as CIMAP, is a frontier plant research laboratory of Council of Scientific and Industrial Research (CSIR).

A leading Pharmacy company with oncology & Critical Care Division

Post: Medical Repersentative

[adsense:336x280:8701650588]

A REPUTED PHARMACY INSTITUTE IN MORADABAD, UP

Post: Assistant Professors in All Discipline of Pharmacy

[adsense:336x280:8701650588]

Job Description
Candidate having acacemic potential and research aptitude shall send their detailed CV on hrpharmacy2015@gmail.com

The Central Council for Research in Homoeopathy (CCRH). New Delhi, an autonomous body under the Ministry of AYUSH, Government of India intends to engage 01 (one) Senior Research Fellow (Pharmacology) on contract basis through Walk-in-Interview as per details given below:

Post: Senior Research Fellow (Pharmacology)

The Indian Pharmacopoeia Commission is an Autonomous Body set up under the Ministry of Health & Family Welfare, Govt. of India primarily with the objectives of regularly updating the Indian Pharmacopoeia by publishing new edition and its addenda, National Formulary of India and other related tasks such as preparing, certification and distribution of reference substances. The I.P. Commission also acts as National Coordination Centre (NCC) for Pharmacovigilance Programme of India (PvPI).

Post: Pharmacopoeial Associates