Srinagar

HEPATOTOXICITY AND HEPATOPROTECTIVE AGENTS : A MINI REVIEW

ABOUT AUTHORS
Mudasir Maqbool1*, Mohmad Amin Dar1, Shafiqa Rasool1, Rabiah Bashir1, Misba Khan 2
1Department of Pharmaceutical Sciences,
University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India
2Mader-E-Meharban Institute of Nursing Sciences and Research,
Jammu And Kashmir, India

ABSTRACT
The maintenance of a healthy liver is vital to overall health of the human beings. Since the liver is involved in almost all biochemical processes and there are many different diseases that will affect it. The liver is often abused by environmental toxins, which are eating habits, alcohol and overdose of certain drugs which can damage and weaken the liver and eventually lead to many diseases. Medicinal herbs are significant source of hepatoprotective drugs. Mono and poly-herbal preparations have been used in various liver disorders. According to one estimate, more than 700 mono and poly-herbal preparations in the form of decoction, tincture, tablets and capsules from more than 100 plants are in clinical use. From the literature review near about 178 medicinal plants are reported to possess a hepatoprotective activity. A drug having beneficial effect on the liver is known as hepatoprotective drug. On the other hand, drugs having toxic effect on the liver are better known as hepatotoxic drugs. The most commonly used parameters to assess the hepatoprotective activity are morphological e.g. Liver weight and volume, biochemical estimations, such as measurement of transaminase activity, SGPT, SCOT, alkaline phosphatase, serum bilirubin, total serum proteins, albumin, globulin and prothrombin time, functional parameters, pentobarbitone and hexobarbitone sleeping time and finally histopathological study regarding presence of necrosis, fatty degeneration and cirrhosis. In this review, we will briefly discuss hepatotoxicity and hepatoprotective agents.

Applications are invited for Project Fellow or Project Associate at HNBGU - M.Pharm or M.Sc can apply

Hemvati Nandan Bahuguna Garhwal University was established as a State University vide U.P. State Government notification no. (10)/(865)/15/(75)(85)/64 dated 23 November 1973. It has a rare distinction of taking birth through a powerful popular movement during early seventies in last century. This movement symbolized the hopes and aspirations of the masses of the region of Garhwal for the development through the instrument of higher education. The people of this remote mountainous region agitated for opening a University at a small but historic semi rural town of Srinagar.

Post : Project Fellow or Project Associate

IIIM SKILL DEVELOPMENT PROGRAM 2019

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Walk in interview for Junior Research Fellow at CCMB

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Sher-i-Kashmir Institute of Medical Sciences was conceived with the following objectives: To provide facilities of specialized medical care and particularly develop super specialties that would provide tertiary health-care. To provide need oriented education in medical sciences and clinical research. To develop a referral linkage between the primary, secondary and tertiary health-care Institutions of the State to achieve an optimum health delivery system.

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Career for Research Associate at SKIMS

Sher-i-Kashmir Institute of Medical Sciences was conceived with to provide facilities of specialized medical care and particularly develop super specialties that would provide tertiary health-care. To provide need oriented education in medical sciences and clinical research. To develop a referral linkage between the primary, secondary and tertiary health-care Institutions of the State to achieve an optimum health delivery system.

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Applications are invited for the post of Junior Research Fellow in HNBGU

Inception of Garhwal University on Dec. 1 st 1973 was the fulfillment of a long cherished dream of the local people .The University was established under the provisions of Uttar Pardesh State Universities Act (Act No. 10 of 1973) on 1.12.1973 and the Act come in force w.e.f. 1.12.1973.
The name of the university was rechristened to Hemwati Nandan Bahuguna Garhwal University in 1989 in commemoration of the memory of a leading statesman of the country, the son of the soil Shri Hemwati Nandan Bahuguna, and subsequently established as Central University under the provision of the Central Universities Ordinance, 2009, No.3 of 2009 published in the gazette of India, extraordinary Part-II, Sec-I, New Delhi, 15 January 2009. Our University is among the ten largest Universities of the country with 3 campuses and more than 180 affiliated colleges and institutes (both state run/aided and self financed) and examining approximately 150000 students annually, providing higher education services in 7 out of the 13 Districts of the State of Uttarakhand.

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