Nellore

Walk in interview for Analyst (Trainees) in MPEDA-Govt of India

The Marine Products Export Development Authority (MPEDA), Ministry of Commerce & Industry, Govt. of India propose to recruit Analyst (Trainees) (1 post at Bhimavaram and 2 posts at Nellore) on contract basis to work in Quality Control Laboratories, Bhimavaram and Nellore (ISO/IEC17025:2005 NABL Accredited / EIC Approved) for a period of two years. Candidates meeting following educational qualifications and interested to work on contract basis can attend the walk-in interview at 10 AM on 03-06-2014 at QC Laboratory, Bhimavaram and at 10 AM on 04-06-2014 at QC Laboratory, Nellore along with bio data and original certificates of educational qualification and experience.

Post: Analyst (Trainees) (1 post at Bhimavaram and 2 posts at Nellore)

REVIEW ON HYDROGEL- A NOVEL CARRIER

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ABOUT AUTHORS:
C. Mallikarjuna*1, V. Hari Bhaskar1, Junju. Mohan Kumar2, Rayaprolu. Mounica2, Sai Padmini Bolla2
1Department of Pharmaceutics, Vagdevi College Of Pharmacy And Research Centre, SPSR Nellore, A. P, India.
2Department of Pharmaceutics, Rao’s College Of Pharmacy, SPSR Nellore, A. P, India.
Mallikarjuna2055@gmail.com

ABSTARCT
Hydrogels are three–dimensional cross-linked hydrophilic polymers that swell in water and aqueous solutions without dissolving in them. Softness, smartness, and the capacity to store water make hydrogels unique materials.Several techniques have been reported for the synthesis of hydrogels like co-polymerization/crosslinking of co-monomers using multifunctional co-monomer, which acts as crosslinking agent. They can be classified in different ways on the basis of their preparation, biodegradable properties, polymer, sensitivity to surrounding environment and also their application. Hydrogels being biocompatible materials have been recognized to function as drug protectors, especially for peptides and proteins, from in-vivo environment. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems. This review mainly deals with the advantages, properties, method of preparation and characterization of hydrogels.

DETERMINATION OF PURITY AND RELATIVE MOLECULAR WEIGHT OF PURIFIED HUMAN IgG

About Authors:
1M Prasad Naidu, 2Dr Madhu Sudan Reddy, 3T Madhu Chaithanya, 4N Mallikarjun Rao

1(Medical Biochemistry) NMCH, Nellore, AP, India.
2(MD Pharmacolgy) NMCH, Nellore, AP, India.
3(Medical Pharmacology) MIMS, Vijayanagaram, AP, India.
4(MSc Botany). Acharya Nagarjuna University, Guntur, AP, India.
*www.prasadnaidu.com@gmail.com

Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)
An important technique for the separation of proteins is based on the migration of charged proteins in an electric field, a process called electrophoresis. These procedures are not generally used to purify proteins in large amounts, because simpler alternatives are usually available and electrophoretic methods often adversely affect the structure and thus the function of proteins. Electrophoresis is, however, especially useful as an analytical method. Its advantage is that proteins can be visualized as well as separated, permitting a researcher to estimate quickly the number of different proteins in a mixture or the degree of purity of a particular protein preparation. Also, electrophoresis allows determination of crucial properties of a protein such as its isoelectric point and approximate molecular weight. The polyacrylamide gel acts as a molecular sieve, slowing the migration of proteins approximately in proportion to their charge-to-mass ratio. Migration may also be affected by protein shape. In electrophoresis, the force moving the macromolecule is the electrical potential, E. The electrophoretic mobility of the molecule, µ, is the ratio of the velocity of the particle molecule, V, to the electrical potential. Electrophoretic mobility is also equal to the net charge of the molecule, Z, divided by the frictional coefficient, f, which reflects in part a protein’s shape.

A REVIEW –COLON SPECIFIC DRUG DELIVERY-APPROACHES

About Authors:
Vijaya Kumar.Voleti*1, Vaishnavi.V2, V.Gunasekharan1, M.S.Riyazullah1, K.Vivekanandan1
1Department of pharmaceutics, Rao’s College of Pharmacy, Nellore, Andhra Pradesh, India,
2Department of pharmaceutics, Sankar Reddy Institute of Pharmaceutical Sciences, Andhra Pradesh, India
*vijay66vvk@gmail.com

ABSTRACT:
Colon specific drug delivery has gained a more importance for the delivery at colonic region by use of various drugs to treat the both local and systemic diseases. Local diseases include Chron’s disease, ulcerative colitis, and colorectal cancer. Other serious disorders like nocturnal asthma, Hyper tension , arthritis and angina can also be cured by these techniques. Colonic delivery is a good candidature for delivery of proteins peptides and vaccines where the enzymatic degradation and the hydrolysis of proteins can be minimized and increases the systemic bioavailability. A drug should be protected from the absorption and the upper GI environment to achieve the successful colonic drug delivery. The colon specific delivery of drugs to the target receptor sites has the advantage to reduce the side effects and improves the therapeutic response. Colon specific drug delivery are being developed by taking advantage of the luminal PH conditions and the presence of microbial enzymes such as azoreductase, pectinase, dextranase…etc. This review mainly reveals on the various concepts and approaches include Prodrug, PH and time dependent systems and microbially triggered systems used in the development of colon specific drug delivery. This also focuses on the novel approaches namely Pressure controlled colonic delivery, osmotic controlled drug delivery and CODESTM. Invitro and in vivo evaluation parameters has been discussed here.

Multiplace Vacancies in Unichem for the post of Business Executive - Gynec Division | all India level

Unichem Laboratories has grown to become one of India’s most respected pharmaceutical companies. It is committed to delivering better health through superior products. By combining strategic research and in-depth industry knowledge, Unichem aims to transform itself into a global pharmaceutical drug company with an increasing focus on cutting-edge research and developed markets.

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